cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLCcardiovascular-1063Research ArticleАТЕРОСКЛЕРОЗATHEROSCLEROSISСвязь липопротеида (а) и гомоцистеина с коронарным атеросклерозом у мужчин молодого и среднего возрастовLipoprotein(a), homocysteine and coronary atherosclerosis in young and middle-aged menЕжовМ. В.EzhovM. V.marat_ezhov@mail.ruТрухачеваЕ. П.TrukhachevaE. P.marat_ezhov@mail.ruАфанасьеваО. И.AfanasyevaO. I.marat_ezhov@mail.ruАфанасьеваМ. И.AfanasyevaM. I.marat_ezhov@mail.ruКамбеговаА. А.KambegovaA. A.marat_ezhov@mail.ruЛякишевА. А.LyakishevA. A.marat_ezhov@mail.ruПокровскийС. Н.PokrovskyS. N.marat_ezhov@mail.ruНИИ клинической кардиологии им. А.Л. Мясникова Российского кардиологического научно-производственного комплекса Росмедтехнологии. МоскваA.L. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical Complex, Federal Agency on High Medical Technologies. Moscow, Russia200820102008751115Copyright © Ежов М.В., Трухачева Е.П., Афанасьева О.И., Афанасьева М.И., Камбегова А.А., Лякишев А.А., Покровский С.Н., 20082008Ежов М.В., Трухачева Е.П., Афанасьева О.И., Афанасьева М.И., Камбегова А.А., Лякишев А.А., Покровский С.Н.Ezhov M.V., Trukhacheva E.P., Afanasyeva O.I., Afanasyeva M.I., Kambegova A.A., Lyakishev A.A., Pokrovsky S.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/1063

Цель. Выяснить, существует ли связь между содержанием гомоцистеина (Гц) и липопротеида (а) [Лп (а)] в сыворотке крови и наличием атеросклероза коронарных артерий у мужчин молодого и среднего возрастов.Материал и методы. В исследование включили 40 мужчин в возрасте 29–58 лет (средний возраст 43,8±6,2), у которых диагноз ишемической болезни сердца (ИБС) был подтвержден данными коронарной ангиографии. Группу контроля (ГК) составили 27 мужчин. Всем исследуемым определяли концентрацию Гц и Лп (а), а также липиды крови: общий холестерин (ОХС), триглицериды (ТГ), ХС липопротеидов высокой плотности (ХС ЛВП). ХС липопротеидов низкой плотности (ХС ЛНП) рассчитывали по формуле Фридвальда.Результаты. Концентрации Гц, Лп (а), ОХС, ХС ЛНП в крови были достоверно выше у больных ИБС, чем у лиц ГК: 12,4±5,8 и 10,0±2,9 мкмоль/л (p<0,05); 37±40 и 13±11 мг/дл (p<0,01); 6,4±1,3 и 5,6±1,0 ммоль/ л (p<0,01); 4,4±1,2 и 3,4±0,9 ммоль/л (p<0,001), соответственно. Концентрация ТГ и ХС ЛВП значимо не отличалась между группами. При множественном регрессионном анализе установлено, что с наличием и тяжестью коронарного атеросклероза независимо связан уровень Лп (а), но не Гц крови. Выявлена прямая корреляция между уровнями Лп (а) и Гц.Заключение. У мужчин молодого и среднего возрастов установлена связь между наличием коронарного атеросклероза и повышенным уровнем Лп (а), но не Гц крови.

Aim

Aim. To investigate the association between serum homocysteine, lipoprotein(a) (Lp(a)) and coronary atherosclerosis in young and middle-aged men.

Material and methods

Material and methods. The study included 40 men aged 29-58 years (mean age 43,8±6,2 years), with coronary heart disease (CHD) verified by coronary angiography. The control group (CG) included 27 CHD-free men. In all participants, concentrations of homocysteine, Lp(a), total cholesterol (TCH), triglycerides (TG), high-density lipoprotein CH (HDL-CH) were assessed. Low-density lipoprotein CH (LDL-CH) level was calculated using Friedewald formula.

Results

Results. Concentrations of homocysteine, Lp(a), TCH, and LDL-CH were significantly higher in CHD patients than in CG individuals: 12,4±5,8 and 10,0±2,9 micromol/l (p<0,05); 37±40 and 13±11 mg/dl (p<0,01); 6,4±1,3 and 5,6±1,0 mmol/l (p<0,01); 4,4±1,2 and 3,4±0,9 mmol/l (p<0,001), respectively. No significant inter-group differences in TG and HDL-CH levels were observed. In multiple regression analysis, coronary atherosclerosis presence and severity was independently associated with Lp(a), but not with homocysteine level. There was a positive correlation between Lp(a) and homocysteine concentrations.

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The authors declare that there are no conflicts of interest present.