cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLCcardiovascular-1076Research ArticleИШЕМИЧЕСКАЯ БОЛЕЗНЬ СЕРДЦАCORONARY HEART DISEASEАссоциация полиморфизма генов ферментов антиокислительной системы с процессом рестенозирования после коронарного стентированияAntioxidant system gene polymorphism and restenosis risk after coronary stentingШуваловаЮ. А.ShuvalovaYu. A.meshkov@cardio.ruМешковА. Н.MeshkovA. N.meshkov@cardio.ruКаминныйА. И.KaminnyA. I.meshkov@cardio.ruСамкоА. Н.SamkoA. N.meshkov@cardio.ruШироковР. О.ShirokovR. O.meshkov@cardio.ruСтамбольскийД. В.StambolskyD. V.meshkov@cardio.ruКухарчукВ. В.KukharchukV. V.meshkov@cardio.ruФГУ “Российский кардиологический научно-производственный комплекс” Росздрава. МоскваRussian FederationФГУ “Российский кардиологический научно-производственный комплекс” Росздрава. МоскваRussian Cardiology Scientific and Clinical Complex, Federal Agency on High Medical Technologies. Moscow200820102008753642Copyright © Шувалова Ю.А., Мешков А.Н., Каминный А.И., Самко А.Н., Широков Р.О., Стамбольский Д.В., Кухарчук В.В., 20082008Шувалова Ю.А., Мешков А.Н., Каминный А.И., Самко А.Н., Широков Р.О., Стамбольский Д.В., Кухарчук В.В.Shuvalova Y.A., Meshkov A.N., Kaminny A.I., Samko A.N., Shirokov R.O., Stambolsky D.V., Kukharchuk V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/1076

Цель. Изучить связи генотипов четырех полиморфизмов генов трех антиокислительных ферментов (гена каталазы, параоксоназы и эндотелиальной синтазы оксида азота) с развитием рестеноза после стентирования коронарных артерий (СКА).Материал и методы. В исследование включены пациенты мужского пола, страдающие ишемической болезнью сердца (ИБС) со стабильной стенокардией, имеющие ангиографически документированный стеноз одной или двух магистральных КА выраженностью не менее 70 %, перенесшие СКА с использованием непокрытого стента и контрольную коронароангиографию через 6 месяцев. Ангиографический рестеноз определяли как сужение КА ≥ 50 % в диаметре в месте стентирования. У всех пациентов были определены генотипы полиморфизмов -262 C/T гена CAT, L55M и Q192R гена PON, E298D гена eNOS.Результаты. В исследовании участвовал 101 пациент, рестеноз выявлен у 44. Полиморфизм E298D гена eNOS ассоциирован с развитием рестеноза в стенте. У носителей D аллеля риск развития рестеноза был выше (p=0,008). Сочетание генотипов LM/QQ полиморфизмов L55M и Q192R гена PON встречалось практически в 2 раза чаще в группе рестеноза – 41 % vs 21 % (p=0,044).Заключение. Генотипирование по полиморфизму E298D гена eNOS и полиморфизмам L55M и Q192R гена PON может применяться для стратификации риска развития рестеноза после СКА у российских пациентов.

Aim. To study the links between four polymorphisms of three antioxidant enzymes (catalase, paraoxonase, endothelial NO synthase) and restenosis risk after coronary artery stenting (CAS).Material and methods. The study included male patients with coronary heart disease (CHD), stable angina and angiographically verified stenosis of one or two main CA ≥70%, after intracoronary CAS with non-eluting stents and control coronary angiography 6 months later. Angiographical stenosis was determined as local reduction in CA diameter ≥50%. In all participants, -262 C/T polymorphism of CAT gene, L55M and Q192R polymorphisms of PON gene, and E298D polymorphism of eNOS gene were identified.Results. The study included 101 patients, and restenosis was diagnosed in 44%. E298D polymorphism of eNOS gene was associated with stent restenosis. In D allele carriers, restenosis risk was higher (p=0,008). The combination of LM/QQ genotypes for L55M and Q192R polymorphisms of PON gene was twice as prevalent in restenosis  group: 41% vs. 21% (p=0,044).Conclusion. Genotyping on E298D polymorphism of eNOS gene and L55M and Q192R polymorphisms of PON gene could be used for post-CAS restenosis risk stratification in Russian patients.

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The authors declare that there are no conflicts of interest present.