cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLCcardiovascular-1097Research ArticleОБЗОР ЛИТЕРАТУРЫLITERATURE REVIEWПлейотропные эффекты ингибиторов ангиотензин-превращающего фермента: существуют ли особые преимущества у сульфгидрильных препаратов?Pleiotropic ACE inhibitor effects: any benefits for sulfhydryl agents?ПреображенскийД. В.PreobrazhenskyD. V.sid_b_a@mail.ruСидоренкоБ. А.SidorenkoB. A.sid_b_a@mail.ruПатараяС. А.S.A. PatarayaS. A.sid_b_a@mail.ruСкорикА. В.SkorikA. V.sid_b_a@mail.ruМосковская медицинская академия им. И. М. Сеченова; Учебно-научный медицинский центр Управления делами Президента Российской ФедерацииI.M. Sechenov Moscow Medical Academy; Education and Research Medical Center, RF President’s AdministrationУчебно-научный медицинский центр Управления делами Президента Российской ФедерацииEducation and Research Medical Center, RF President’s AdministrationЦКБ Управления делами Президента Российской Федерации, г. МоскваCentral Clinical Hospital, RF President’s Administration. Moscow20082002200871116123Copyright © Преображенский Д.В., Сидоренко Б.А., Патарая С.А., Скорик А.В., 20082008Преображенский Д.В., Сидоренко Б.А., Патарая С.А., Скорик А.В.Preobrazhensky D.V., Sidorenko B.A., S.A. Pataraya S.A., Skorik A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/1097

Рассматривается клиническая фармакология ингибиторов ангиотензин-превращающих ферментов (ИАПФ) и, в частности сравниваются фармакологические эффекты отдельных препаратов в зависимости от наличия или отсутствия в их молекулах сульфгидрильных групп. ИАПФ с сульфгидрильными группами каптоприл и в особенности зофеноприл выделяются среди других ИАПФ более выраженными антиокислительными свойствами и, по-видимому, оказывают выраженные кардио- и вазопротективное действия. Приводятся данные литературы, которые указывают на определенные преимущества этих сульфгидрильных ИАПФ, которые делают их препаратами первого ряда для лечения острого инфаркта миокарда и других форм ИБС, а также артериальной гипертензии и сахарного диабета, в патогенезе которых важную роль играет окислительный стресс.

Clinical pharmacology of ACE inhibitors is described, comparing pharmacological effects of agents with or without sulfhydryl groups in their molecules. Sulfhydryl group-containing ACE inhibitors – captopril and especially zofenopril – are characterized by greater antioxidant properties and, potentially, stronger cardio- and vasoprotective action. Literature data confirm benefits of these sulfhydryl ACE inhibitors as first-line medications for treating acute myocardial infarction, other coronary heart disease forms, arterial hypertension and diabetes mellitus, due to important pathogenetic role of oxidative stress.

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The authors declare that there are no conflicts of interest present.