cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2013-1-67-72cardiovascular-112Research ArticleМНЕНИЕ ПО ПРОБЛЕМЕOPINION ON A PROBLEMГЕНЫ-КАНДИДАТЫ РЕЗИСТЕНТНОСТИ К АЦЕТИЛСАЛИЦИЛОВОЙ КИСЛОТЕ И ИХ СВЯЗЬ С РИСКОМ РАЗВИТИЯ СЕРДЕЧНО-СОСУДИСТЫХ КАТАСТРОФASPIRIN RESISTANCE CANDIDATE GENES AND THEIR ASSOCIATION WITH THE RISK OF CARDIOVASCULAR EVENTSГринштейнЮ. И.GrinshteinYu. I.

доктор медицинских наук, профессор, заведующий кафедрой терапии ИПО

Тел.: 8 (391) 2642718

tel.: 8 (391) 2642718

grinstein.yi@gmail.comКосиноваА. А.KosinovaA. A.

аспирант кафедры

ГринштейнИ. Ю.GrinshteinI. Yu.

кандидат медицинских наук, докторант кафедры поликлинической терапии

ГБОУ ВПО «Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого Минздрава России», КрасноярскProf. V.F. Voyno-Yasenetskyi Krasnoyarsk State Medical University, Krasnoyarsk2013200220131216772Copyright © Гринштейн Ю.И., Косинова А.А., Гринштейн И.Ю., 20132013Гринштейн Ю.И., Косинова А.А., Гринштейн И.Ю.Grinshtein Y.I., Kosinova A.A., Grinshtein I.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/112

В обзоре представлены современные данные мировой литературы о наиболее вероятных полиморфизмах генов резистентности к аспирину. Таких как: полиморфизмы циклооксигеназы, гликопро- теинов GP Ib/IIIa, GP Ibα, GP VI аденозиндифосфат рецепторов P2Y1, P2Y12. Рассмотрена частота распространения полиморфизмов при лабораторной аспирин-резистентности, связь данных полиморфизмов с развитием неблагоприятных сердечно-сосудистых событий на фоне приема аспирина. 

The review presents the current literature evidence on the most likely genetic polymorphisms of aspirin resistance, such as polymorphisms of cyclooxygenase, glycoproteins GP Ib/IIIa, GP Ibα, GP VI, and adenosine diphosphate receptors P2Y1 and P2Y12. The authors discuss the prevalence of these polymorphisms in laboratory and clinical aspirin resistance, as well as their association with the risk of cardiovascular events during aspirin treatment. 

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The authors declare that there are no conflicts of interest present.