cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLCcardiovascular-1165Research ArticleМНЕНИЕ ПО ПРОБЛЕМЕOPINION ON A PROBLEMРоль системного воспаления в развитии кардиоваскулярной и акушерской патологииSystem inflammation role in cardiovascular and obstetric pathologyИгитоваМ. Б.IgitovaM. B.

Барнаул, Алтайский край, тел.; (3852) 41-47-28

Barnaul, Altay Region

dagdamor@mail.ruВоробьеваЕ. В.WobievaE. V.

Барнаул, Алтайский край, тел.; (3852) 41-47-28

Barnaul, Altay Region

dagdamor@mail.ruОсиповаИ. В.OsipovaE. V.

Барнаул, Алтайский край, тел.; (3852) 41-47-28

Barnaul, Altay Region

dagdamor@mail.ruГольцоваН. П.Gol’tsovaN. P.

Барнаул, Алтайский край, тел.; (3852) 41-47-28

Barnaul, Altay Region

dagdamor@mail.ruГОУ ВПО Алтайский государственный медицинский университет РосздраваAltay State Medical University200920022009818187Copyright © Игитова М.Б., Воробьева Е.В., Осипова И.В., Гольцова Н.П., 20092009Игитова М.Б., Воробьева Е.В., Осипова И.В., Гольцова Н.П.Igitova M.B., Wobieva E.V., Osipova E.V., Gol’tsova N.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/1165

В последние годы заметно возросло понимание значимости воспалительного компонента в патогенезе сердечно-сосудистых заболеваний (ССЗ), а традиционные факторы риска (ФР) кардиоваскулярной патологии были существенно дополнены результатами изучения роли провоспалительных медиаторов в развитии атеросклероза. Отчетливо прослеживается общность клинических ФР атеросклероза и типичных акушерских осложнений — гестозов и хронической плацентарной недостаточности. Высокоинформативным предиктором развития атеросклеротических осложнений служит маркер внутрисосудистого воспаления — С-реактивный белок, определяемый методом высокочувствительного анализа (hsCRP). Исследования этого маркера при гестационных осложнениях немногочисленны и противоречивы, и на сегодняшний день не существует четкого представления о роли системной воспалительной реакции в физиологии и патологии беременности.

Recently, the role of inflammatory component in cardiovascular disease (CVD) pathogenesis has been widely accepted, and traditional CVD risk factors (RFs) were supplemented by the evidence on pro-inflammatory mediators’ role in atherosclerosis pathogenesis. At the same time, there is an overlap between chnical RFs of atherosclerosis and typical obstetric complications — gestoses and chronic placental insufficiency. Highly informative predictor of atherosclerotic complications is a marker of intravascular inflammation — highly sensitive C-reactive protein (hsCRP). The studies on hsCRP in obstetric complications are scarce and contradictory, and at the moment, there is no clear hypothesis of systemic inflammation role in pregnancy physiology and pathology.

С-реактивный белоквоспалениеатеросклерозбеременностьакушерские осложненияC-reactive proteininflammationatherosclerosispregnancyobstetrics complicationsReferencesБельков В.В. С-реактивный белок — “золотонмаркер”, многозначительный и незаменимый. Новое в клинической лабораторной диагностике атерогенеза: С-реактивный белок, холес-терины, аполипопротеины. Пущино: ОНТИ ПНЦ РАН 2005; 47 с.Бельков В.В. С-реактивный белок — “золотонмаркер”, многозначительный и незаменимый. Новое в клинической лабораторной диагностике атерогенеза: С-реактивный белок, холес-терины, аполипопротеины. Пущино: ОНТИ ПНЦ РАН 2005; 47 с.Вергкин А.Л., ЕЛ. Прохорович, Т.В. Кульниченко. Роль ста-тинов в лечении больных острым коронарным синдромом без подъема сегмента ST. Фарматека 2006; 20(135): 63—9.Вергкин А.Л., ЕЛ. Прохорович, Т.В. Кульниченко. Роль ста-тинов в лечении больных острым коронарным синдромом без подъема сегмента ST. Фарматека 2006; 20(135): 63—9.Киншт Д.Н., Всрешапш В.И.. Пасман Н.М., Верещагин И.П. Поздний гестоз как системная воспалительная реакция. Вестн. интенстер 1999;,2:23-8.Киншт Д.Н., Всрешапш В.И.. Пасман Н.М., Верещагин И.П. Поздний гестоз как системная воспалительная реакция. Вестн. интенстер 1999;,2:23-8.Макацария А.Д., Бгщадзе В.О., Акиньшина С.В. Синдром системного: воспалительного ответа в акушерстве. М.: МИА 2006; 448 с.Макацария А.Д., Бгщадзе В.О., Акиньшина С.В. Синдром системного: воспалительного ответа в акушерстве. М.: МИА 2006; 448 с.Полёвщиков А.В., Назаров П.Е С-реакшвный белок и сывороточный амилоид Р: роль в иммунорегудяцни, Иммунология 1998;4:4-11.Полёвщиков А.В., Назаров П.Е С-реакшвный белок и сывороточный амилоид Р: роль в иммунорегудяцни, Иммунология 1998;4:4-11.Радзинский В.Е., Запертова Е.Ю. Прогестерон-обусловленные изменения провоспалительных цитокинов при привычном невынашивании беременности. Ж акушжен бол 2004; 53(вып. 4): 59—61.Радзинский В.Е., Запертова Е.Ю. Прогестерон-обусловленные изменения провоспалительных цитокинов при привычном невынашивании беременности. Ж акушжен бол 2004; 53(вып. 4): 59—61.Сотникова Н.Ю., Кудряшова ЛВ., Посисеева Л.В., Веденеева М.В. Регуляция FAS-индуцированного апоптоза мононукле-арных клеток периферической крови и плаценты при задержке развития плода. Цитокины и восп 2006; 5(3): 10—5.Сотникова Н.Ю., Кудряшова ЛВ., Посисеева Л.В., Веденеева М.В. Регуляция FAS-индуцированного апоптоза мононукле-арных клеток периферической крови и плаценты при задержке развития плода. Цитокины и восп 2006; 5(3): 10—5.Титов В.Н., Осипов С.Е Атеросклероз. Роль эндогенного воспаления, белков острой фазы и жирных кислот. Москва 2003; 279 с.Титов В.Н., Осипов С.Е Атеросклероз. Роль эндогенного воспаления, белков острой фазы и жирных кислот. Москва 2003; 279 с.Титов В.IT, С-реактивный белок — тест нарушения “чистоты” межклеточной среды организма при накоплении “биологического мусора” большой молекулярной массы. Клинлаб диаг 2008; 2: 3-14.Титов В.IT, С-реактивный белок — тест нарушения “чистоты” межклеточной среды организма при накоплении “биологического мусора” большой молекулярной массы. Клинлаб диаг 2008; 2: 3-14.- Фомин В.В., Козловская Л.В. С-реактивный белок и его значение в кардиологической практике. Cons med 2003; 5(5): 247-50.- Фомин В.В., Козловская Л.В. С-реактивный белок и его значение в кардиологической практике. Cons med 2003; 5(5): 247-50.Чембарцева И.В. Течение и исходы родов у женщин с экстра-генитальной и акушерской патологией. Наука производству 2005; 4:38-9.Чембарцева И.В. Течение и исходы родов у женщин с экстра-генитальной и акушерской патологией. Наука производству 2005; 4:38-9.Шевченко О.П. Высокочувствительный анализ С-реактивного белка и его применение в кардиологии. Лаборат мед 2003; 6: 3-6.Шевченко О.П. Высокочувствительный анализ С-реактивного белка и его применение в кардиологии. Лаборат мед 2003; 6: 3-6.Шифман Е.М. Преэклампсия, эклампсия, HELLP-синдром. Петрозаводск: ИшелТек 2002; 432 с.Шифман Е.М. Преэклампсия, эклампсия, HELLP-синдром. Петрозаводск: ИшелТек 2002; 432 с.Ajani UA, Ford ES, Mokdad AH. Dietary Fiber and C-Reactive Protein: Findings from National Health and Nutrition Examination Survey Data. J Nutr 2004; 134:1181-5.Ajani UA, Ford ES, Mokdad AH. Dietary Fiber and C-Reactive Protein: Findings from National Health and Nutrition Examination Survey Data. J Nutr 2004; 134:1181-5.Azadbakht L, Kimiagar M, Mehrabi Y, et al. Cardiovascular and Metabolic Risk. Soy Consumption, Markers of Inflanmration, and Endothelial Function. A cross-over study in postmenopausal women with tire metabolic syndrome. Diabetes Care 2007; 30: 967-73.Azadbakht L, Kimiagar M, Mehrabi Y, et al. Cardiovascular and Metabolic Risk. Soy Consumption, Markers of Inflanmration, and Endothelial Function. A cross-over study in postmenopausal women with tire metabolic syndrome. Diabetes Care 2007; 30: 967-73.Bellamy L, Casas J-P, Elingorani AD, Williams DJ. Pre-eclampsia and risk of cardiovascular disease and carreer in later life: systematic review and meta-analysis. BMJ 2007; 335:974-85.Bellamy L, Casas J-P, Elingorani AD, Williams DJ. Pre-eclampsia and risk of cardiovascular disease and carreer in later life: systematic review and meta-analysis. BMJ 2007; 335:974-85.Belo L, Santos-Silva Л, Rocha S, et al. Fluctuations in C-reactive protein concentration and neutrophil activation during normal human pregnancy. Eur. J Obst Gyirec Reprod Biol 2005; 123: 46-51.Belo L, Santos-Silva Л, Rocha S, et al. Fluctuations in C-reactive protein concentration and neutrophil activation during normal human pregnancy. Eur. J Obst Gyirec Reprod Biol 2005; 123: 46-51.BretelleF, Sabatier F,ShojaiR,etal.Avancfiesdanslaphysiopatholqgie de la prit-ficlanrpsie: place de la ritponse inflanmratoire. Gyirec Obst Fert 2004; 32(6): 482-9.BretelleF, Sabatier F,ShojaiR,etal.Avancfiesdanslaphysiopatholqgie de la prit-ficlanrpsie: place de la ritponse inflanmratoire. Gyirec Obst Fert 2004; 32(6): 482-9.Brooks N, Layne Ё, Gordon PL, et al. Strength training improves muscle quality and insulin sensitivity in Hispanic older adults with type 2 diabetes. Int J Med Sci 2006; 4(1): 19—27.Brooks N, Layne Ё, Gordon PL, et al. Strength training improves muscle quality and insulin sensitivity in Hispanic older adults with type 2 diabetes. Int J Med Sci 2006; 4(1): 19—27.Campia U, Matuskey LA, Panza JA. Peroxisome proliferator-activated receptor-ganmia activation witli pioglitazone improves endothelium-dependent dilation in nondiabetic patients with major cardiovascular risk factors. Circulation 2006; 113(6): 867—75.Campia U, Matuskey LA, Panza JA. Peroxisome proliferator-activated receptor-ganmia activation witli pioglitazone improves endothelium-dependent dilation in nondiabetic patients with major cardiovascular risk factors. Circulation 2006; 113(6): 867—75.Carroll MF, Scliade D.S. Timing of antioxidant vitamin ingestion alters postprandial proatlierqgenic senmi markers. Circulation 2003; 108(1): 24-31.Carroll MF, Scliade D.S. Timing of antioxidant vitamin ingestion alters postprandial proatlierqgenic senmi markers. Circulation 2003; 108(1): 24-31.Cliae CU, Lee RT, RifaiN, et al. Blood pressure and inflammation in apparently healthy men. Hypertension 2001; 38: 399—403.Cliae CU, Lee RT, RifaiN, et al. Blood pressure and inflammation in apparently healthy men. Hypertension 2001; 38: 399—403.Chan DC, Witts GF, Barrett P.H. Effect of atorvastatin and fish oil on plasma high-sensitivity C-reactive protein concentrations in individuals with visceral obesity. Clin Chem 2002; 48(6) Pt.l: 877-83.Chan DC, Witts GF, Barrett P.H. Effect of atorvastatin and fish oil on plasma high-sensitivity C-reactive protein concentrations in individuals with visceral obesity. Clin Chem 2002; 48(6) Pt.l: 877-83.CookNR, BuringJE, Ridker P.M. The Effect of Including C-Reactive Protein in Cardiovascular Risk Prediction Models for Wmien. Aim Intern Med 2006; 145:21-9.CookNR, BuringJE, Ridker P.M. The Effect of Including C-Reactive Protein in Cardiovascular Risk Prediction Models for Wmien. Aim Intern Med 2006; 145:21-9.Coussons-Read ME, Okim ML, Nettles CD. Psychosocial stress increases inflammatory markers and alters cytokine production across pregnancy. Brain, Behav hum 2007; 21(3): 343-50.Coussons-Read ME, Okim ML, Nettles CD. Psychosocial stress increases inflammatory markers and alters cytokine production across pregnancy. Brain, Behav hum 2007; 21(3): 343-50.Dahler-Eriksen BS, Lauritzen T, Lassen JF, et al. Near-patient test for C-reactive protein in general practice: assessment of clinical, organizational, and economic outcomes. Clin Chem 1999; 45(4): 478-85.Dahler-Eriksen BS, Lauritzen T, Lassen JF, et al. Near-patient test for C-reactive protein in general practice: assessment of clinical, organizational, and economic outcomes. Clin Chem 1999; 45(4): 478-85.Duckitt K, Harrington D. Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies. BMJ 2005; 330: 565.Duckitt K, Harrington D. Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies. BMJ 2005; 330: 565.Duncan BB, Schmidt MI, Pankow JS, et al. Low-Grade Systemic Inflammation and the Development of Type 2 Diabetes. Diabetes 2003; 52:1799-805.Duncan BB, Schmidt MI, Pankow JS, et al. Low-Grade Systemic Inflammation and the Development of Type 2 Diabetes. Diabetes 2003; 52:1799-805.Egawa H, Fujiwara H, Hirano T, et al. Peripheral blood mononuclear cells in early pregnancy promote invasion of human choriocarcinoma cell line, BeWo cells. Hrmi Reprod 2002; 17(2): 473-80.Egawa H, Fujiwara H, Hirano T, et al. Peripheral blood mononuclear cells in early pregnancy promote invasion of human choriocarcinoma cell line, BeWo cells. Hrmi Reprod 2002; 17(2): 473-80.Engstrom G, Janzon L, Berglimd G, et al. Blood pressure increase and incidence of hypertension in relation to inflanmiation-sensitive plasma proteins. Arterios Tlirom Vas Biol 2002; 22: 2054-8.Engstrom G, Janzon L, Berglimd G, et al. Blood pressure increase and incidence of hypertension in relation to inflanmiation-sensitive plasma proteins. Arterios Tlirom Vas Biol 2002; 22: 2054-8.Erlinger TP, Miller ER, Charleston J, Appel U. Inflammation modifies the effects of a reduced-fat low-cholesterol diet on lipids: results from the DASH-sodium trial. Circulation 2003; 108(2): 150-4.Erlinger TP, Miller ER, Charleston J, Appel U. Inflammation modifies the effects of a reduced-fat low-cholesterol diet on lipids: results from the DASH-sodium trial. Circulation 2003; 108(2): 150-4.Facchinetti F, Paganelli S, "Vferturini P, et al. Mediatory biochimici delle modificazioni cervicali nel parto pretermine. G Ital Obstet e Ginecol 2006; 28(1-2): 11-5.Facchinetti F, Paganelli S, "Vferturini P, et al. Mediatory biochimici delle modificazioni cervicali nel parto pretermine. G Ital Obstet e Ginecol 2006; 28(1-2): 11-5.Folson AR, Grundy SM, Ballantyne CM. С-Reactive Protein: Basic and Clinical Research Needs. NHLBI Workshop Report, July 10-11,2006.Folson AR, Grundy SM, Ballantyne CM. С-Reactive Protein: Basic and Clinical Research Needs. NHLBI Workshop Report, July 10-11,2006.Gojnic M, Fazlagic A, Pervulov M, et al.The significance of C-reactive protein in the diagnosis of fetal tachycardia and therapy of chorioanmionitis. Clin Exp Obstet Gynecol 2005; 32(2): 114—6.Gojnic M, Fazlagic A, Pervulov M, et al.The significance of C-reactive protein in the diagnosis of fetal tachycardia and therapy of chorioanmionitis. Clin Exp Obstet Gynecol 2005; 32(2): 114—6.Haider DG, Leuchten N, Schaller G, et al. C-reactive protein is expressed and secreted by peripheral blood mononuclear cells. Clin experimmun2006; 146(3): 533—9.Haider DG, Leuchten N, Schaller G, et al. C-reactive protein is expressed and secreted by peripheral blood mononuclear cells. Clin experimmun2006; 146(3): 533—9.Hsu PY, Lin CL, Yu CC. et al. Ultrapure dialysate improves iron utilization and erythropoietin response in chronic hemodialysis patients — a prospective cross-over study. J Nephrol 2004; 17(5): 693-700.Hsu PY, Lin CL, Yu CC. et al. Ultrapure dialysate improves iron utilization and erythropoietin response in chronic hemodialysis patients — a prospective cross-over study. J Nephrol 2004; 17(5): 693-700.Hudgins LC, Parker TS, Levine DM, et al. A single intravenous dose of endotoxin rapidly alters senmi lipoproteins and lipid transfer proteins in normal volunteers. J lipid Res 2003; 44(8): 489-98.Hudgins LC, Parker TS, Levine DM, et al. A single intravenous dose of endotoxin rapidly alters senmi lipoproteins and lipid transfer proteins in normal volunteers. J lipid Res 2003; 44(8): 489-98.Koh KK, Quon MJ, Han SH, et al. Viscular and metabolic effects of combined therapy with ramipril and simvastatin in patients with type 2 diabetes. Hypertension 2005; 45(6): 1088-93.Koh KK, Quon MJ, Han SH, et al. Viscular and metabolic effects of combined therapy with ramipril and simvastatin in patients with type 2 diabetes. Hypertension 2005; 45(6): 1088-93.Koh KK, Schenke WH, Waclawiw VA, et al. Statin attenuates increase in C-ieactive protein during estrogen replacement therapy in postmenopausal women. Circulation 2002; 105(13): 1531—3.Koh KK, Schenke WH, Waclawiw VA, et al. Statin attenuates increase in C-ieactive protein during estrogen replacement therapy in postmenopausal women. Circulation 2002; 105(13): 1531—3.Коп H, Nagano M, Tanaka F, et al. Association of Decreased Variation of R-R Interval and Elevated Senmi С-Reactive Protein Level in a General Population in Japan. Intern Heart J 2006; 47(6): 867-76.Коп H, Nagano M, Tanaka F, et al. Association of Decreased Variation of R-R Interval and Elevated Senmi С-Reactive Protein Level in a General Population in Japan. Intern Heart J 2006; 47(6): 867-76.Lalioz C, Schaefer EJ, Clippies LA, et al. Apolipoprotein E genotype and cardiovascular disease in the Framingham Heart Study. Atherosclerosis 2001; 154(3): 529-37.Lalioz C, Schaefer EJ, Clippies LA, et al. Apolipoprotein E genotype and cardiovascular disease in the Framingham Heart Study. Atherosclerosis 2001; 154(3): 529-37.McVeigh BL, Dillingham BL, Lampe JW, Duncan AM. Effect of soy protein varying in isoflavone content on senmi lipids in healthy young men. Am J Clin Nutr 2006; 83(2): 244-51.McVeigh BL, Dillingham BL, Lampe JW, Duncan AM. Effect of soy protein varying in isoflavone content on senmi lipids in healthy young men. Am J Clin Nutr 2006; 83(2): 244-51.Nazmi A, Viet ora CG. Socioeconomic and racial/ethnic differentials of C-reactive protein levels: a systematic review of population-based studies.BMC Public Health 2007; 7: 212.Nazmi A, Viet ora CG. Socioeconomic and racial/ethnic differentials of C-reactive protein levels: a systematic review of population-based studies.BMC Public Health 2007; 7: 212.Pai JK, Pischon T, Ma J, et al. Inflammatory markers and the risk of coronary heart disease in men and women. N Eng J Med 2004; 351(25): 2599-610.Pai JK, Pischon T, Ma J, et al. Inflammatory markers and the risk of coronary heart disease in men and women. N Eng J Med 2004; 351(25): 2599-610.Paternoster DM, Fantinato S, Stella A, et al. C-reactive protein in hypertensive disorders in pregnancy. Clin Appl Thromb/Hemost 2006; 12(3): 330-7.Paternoster DM, Fantinato S, Stella A, et al. C-reactive protein in hypertensive disorders in pregnancy. Clin Appl Thromb/Hemost 2006; 12(3): 330-7.Peason ТА, Mensali GA, Alexander RW, et al. Markers of Inflammation and Cardiovascular Disease. Circulation 2003; 107: 499-511.Peason ТА, Mensali GA, Alexander RW, et al. Markers of Inflammation and Cardiovascular Disease. Circulation 2003; 107: 499-511.Pitiphat W, Gillman MW Joshipura KJ, et al. Plasma C-Reactive Protein in Early Pregnancy and Preterm Delivery. Am J Epidem 2005; 162(11): 1108-13.Pitiphat W, Gillman MW Joshipura KJ, et al. Plasma C-Reactive Protein in Early Pregnancy and Preterm Delivery. Am J Epidem 2005; 162(11): 1108-13.Qiu C, Sorensen TK, Luthy DA, Williams MA. A prospective study of maternal senmi C-reactive protein (CRP) concentrations and risk of gestational diabetes meffitus. Paed PerinEpid 2004; 18(5): 377-84.Qiu C, Sorensen TK, Luthy DA, Williams MA. A prospective study of maternal senmi C-reactive protein (CRP) concentrations and risk of gestational diabetes meffitus. Paed PerinEpid 2004; 18(5): 377-84.Redman CWG, Sacks GP, Sargent IL. Preeclampsia: An excessive maternal inflammatory response to pregnancy. Am J Obstet Gynecol 1999;180:499-506. "Redman CWG, Sacks GP, Sargent IL. Preeclampsia: An excessive maternal inflammatory response to pregnancy. Am J Obstet Gynecol 1999;180:499-506. "Ridker PM, Cannon CP, Monow D, et al. C-reactive protein levels and outcomes after statin therapy. N Engl J Med 2005; 352(1): 20—8.Ridker PM, Cannon CP, Monow D, et al. C-reactive protein levels and outcomes after statin therapy. N Engl J Med 2005; 352(1): 20—8.Ropponen A, Aittonmki K, Tikkanen MJ, Ylikorkala O. Levels of senmi C-reactive protein during oral and transdermal estradiol in postmenopausal women with and without a history of intrahepatic cholestasis of pregnancy. J Clin Endocrinol Metab 2005; 90(1): 142-6.Ropponen A, Aittonmki K, Tikkanen MJ, Ylikorkala O. Levels of senmi C-reactive protein during oral and transdermal estradiol in postmenopausal women with and without a history of intrahepatic cholestasis of pregnancy. J Clin Endocrinol Metab 2005; 90(1): 142-6.Sesso HD, Buring JE, Blake GJ, et al. C-reactive protein and the risk of developing hypertension. JAMA 2003; 290: 2945-51.Sesso HD, Buring JE, Blake GJ, et al. C-reactive protein and the risk of developing hypertension. JAMA 2003; 290: 2945-51.Sierksma A, van der Gaag MS, Kluft C, Hendriks HE Moderate alcohol consumption reduces plasma C-reactive protein and fibrinogen levels; a randomized, diet-controlled intervention study. EurJ Clin Nutr 2002; 56(11): 1130-6.Sierksma A, van der Gaag MS, Kluft C, Hendriks HE Moderate alcohol consumption reduces plasma C-reactive protein and fibrinogen levels; a randomized, diet-controlled intervention study. EurJ Clin Nutr 2002; 56(11): 1130-6.Tarim E, Bagis T, Kilicdag EB, et al. Are amniotic fluid C-reactive protein and glucose levels, and white blood cell counts at the time of genetic amniocentesis related with preterm delivery? J perinat med 2005; 33(6): 524-9.Tarim E, Bagis T, Kilicdag EB, et al. Are amniotic fluid C-reactive protein and glucose levels, and white blood cell counts at the time of genetic amniocentesis related with preterm delivery? J perinat med 2005; 33(6): 524-9.Tayade C, Black GP, Fang Y, Cray BA. Differential gene expression in endometrium, endometrial lymphocytes, and trophoblasts during successful and abortive embryo implantation. J Immunol 2006; 176(1): 148-56.Tayade C, Black GP, Fang Y, Cray BA. Differential gene expression in endometrium, endometrial lymphocytes, and trophoblasts during successful and abortive embryo implantation. J Immunol 2006; 176(1): 148-56.Ustim Y, Engin-Ustim Y, Kamaci M. Association of fibrinogen and C-reactive protein with severity Of preeclampsia. Eur J obst, gynec reprod biol 2005; 121(2): 154—8.Ustim Y, Engin-Ustim Y, Kamaci M. Association of fibrinogen and C-reactive protein with severity Of preeclampsia. Eur J obst, gynec reprod biol 2005; 121(2): 154—8.Van den Broek NR, Letsky EA. Etiology of anemia in pregnancy in south Malawi. Am J Clin Nutr 2000; 72(Suppl. 1): 247S-56.Van den Broek NR, Letsky EA. Etiology of anemia in pregnancy in south Malawi. Am J Clin Nutr 2000; 72(Suppl. 1): 247S-56.Watts DH, Krohn MA, Wener MH, Eschenbaeh DA. O-Reactive Protein in Normal Pregnancy. Obst Gynec 1991; 77: 176-80.Watts DH, Krohn MA, Wener MH, Eschenbaeh DA. O-Reactive Protein in Normal Pregnancy. Obst Gynec 1991; 77: 176-80.Wolf M, Kettyle B, Sandler L et al. Obesity and Preeclampsia: The Potential Role of hiflammation. Obst Gynec 2001; 98: 757—62.Wolf M, Kettyle B, Sandler L et al. Obesity and Preeclampsia: The Potential Role of hiflammation. Obst Gynec 2001; 98: 757—62.

The authors declare that there are no conflicts of interest present.