cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLCcardiovascular-1168Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEW ARTICLESИнгибитор ангиотензин-превращающего фермента зофеноприл в лечении больных инфарктом миокарда: обзор исследований проекта SMILEACE inhibitor zofenopril in treatment of myocardial infarction patients: review of SMILE Project trialsЛопатинЮ. М.LopatinYu. M.lopatin@sprint-v.com.ruВолгоградский государственный медицинский университет; Волгоградский областной кардиологический центр. ВолгоградVolgograd State Medical University; Volgograd Regional Cardiology Center. Volgograd20062004200652106111Copyright © Лопатин Ю.М., 20062006Лопатин Ю.М.Lopatin Y.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/1168

Проанализированы результаты рандомизированных, клинических испытаний, которые составляют проект SMILE (The Survival of Myocardial Infarction Long term Evaluation). Показано, что назначение ингибитора ангиотензин-превращающего фермента зофеноприла больным острым инфарктом миокарда на протяжении шести недель ведет к 29% снижению смертности на протяжении одного года наблюдения. Отмечено, что зофеноприл безопасен и хорошо переносится больными острым инфарктом миокарда. Рассмотрены продолжающиеся исследования с этим препаратом.

The results of randomized clinical trials comprising SMILE (The Survival of Myocardial Infarction Long term Evaluation) Project were analyzed. Six-week therapy with an ACE inhibitor zofenopril in acute myocardial infarction (AMI) patients resulted in one-year mortality reduction by 29%. Xofenopril was safe and well-tolerated in AMI patients. Ongoing zofenopril trials are also reviewed.

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The authors declare that there are no conflicts of interest present.