cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLCcardiovascular-1208Research ArticleМНЕНИЕ ПО ПРОБЛЕМЕНатрийуретические пептиды и хроническая сердечная недостаточность у больных артериальной гипертензиейNatriuretic peptides and chronic heart failure in arterial hypertension patientsВасюкЮ. А.VasuykYu. A.hadzedova@inbox.ruХадзеговаА. Б.KhadzegovaA. B.hadzedova@inbox.ruИвановаС. В.IvanovaS. V.hadzedova@inbox.ruАмирбегишвилиИ. М.AmirbegishviliI. M.hadzedova@inbox.ruГерасимоваН. И.GerasimovaN. I.hadzedova@inbox.ruЮщукЕ. Н.YushchukE. N.hadzedova@inbox.ruКрикуноваО. В.KrikunovaO. V.hadzedova@inbox.ruБицуевВ. Г.BitsuevV. G.hadzedova@inbox.ruМосковский государственный медико-стоматологический университет, МоскваMoscow State Medico-Stomatological University, MoscowГУЗ «Кардиологический центр», НальчикCardiology Center, Nal'chik200720042007627579Copyright © Васюк Ю.А., Хадзегова А.Б., Иванова С.В., Амирбегишвили И.М., Герасимова Н.И., Ющук Е.Н., Крикунова О.В., Бицуев В.Г., 20072007Васюк Ю.А., Хадзегова А.Б., Иванова С.В., Амирбегишвили И.М., Герасимова Н.И., Ющук Е.Н., Крикунова О.В., Бицуев В.Г.Vasuyk Y.A., Khadzegova A.B., Ivanova S.V., Amirbegishvili I.M., Gerasimova N.I., Yushchuk E.N., Krikunova O.V., Bitsuev V.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/1208

В обзоре обсуждаются возможности натрийуретических пептидов в оценке систолической и диастолической дисфункций левого желудочка и диагностике его гипертрофии у больных артериальной гипертензией (АГ). Представлены данные о возможном влиянии антигипертензивной терапии на уровень мозгового натрийуретического пептида у больных АГ.

The review is devoted to natriuretic peptides perspectives in left ventricular (LV) systolic and diastolic dysfunction assessment and LV hypertrophy diagnostics in arterial hypertension (AH) patients. The data describing possible antihypertensive therapy effects on brain natriuretic peptide level in AH patients are presented.

натрийуретические пептидыдисфункция левого желудочкаартериальная гипертензияnatriuretic peptidesleft ventricular dysfunctionarterial hypertensionReferencesThe SOLVD Investigators. Effect of enalapril on survival in patients with reduced left ventricular ejection fraction and congestive heart failure. N Engl J Med 1991; 325: 293-302.The SOLVD Investigators. Effect of enalapril on survival in patients with reduced left ventricular ejection fraction and congestive heart failure. N Engl J Med 1991; 325: 293-302.MERIT4HF study group. Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT4HF). Lancet 1999; 353: 293-302.MERIT4HF study group. Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT4HF). Lancet 1999; 353: 293-302.Pitt B, Zannad F, Remme WJ, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomised Aldactone Evaluation Study Investigators. N Engl J Med 1999; 341: 709-17.Pitt B, Zannad F, Remme WJ, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomised Aldactone Evaluation Study Investigators. N Engl J Med 1999; 341: 709-17.Агеев Ф.Т., Даниелян М.О., Мареев Ю.В., Беленков Ю.Н. Больные с хронической сердечной недостаточностью в российской амбулаторной практике: особенности контингента, диагностики и лечения (по материалам исследования ЭПОХА4О4ХСН). Серд недостат 2004; 1: 4-7.Агеев Ф.Т., Даниелян М.О., Мареев Ю.В., Беленков Ю.Н. Больные с хронической сердечной недостаточностью в российской амбулаторной практике: особенности контингента, диагностики и лечения (по материалам исследования ЭПОХА4О4ХСН). Серд недостат 2004; 1: 4-7.Vasan RS, Benjamin EL, Levy D. Congestive heart failure with normal left ventricular systolic function: clinical approaches to the diagnosis and treatment of diastolic heart failure. Arch Intern Med 1996; 156(2): 146-65.Vasan RS, Benjamin EL, Levy D. Congestive heart failure with normal left ventricular systolic function: clinical approaches to the diagnosis and treatment of diastolic heart failure. Arch Intern Med 1996; 156(2): 146-65.Slama M, Susic D, Varagic J, et al. Diastolic dysfunction in hypertension. Curr Opin Cardiol 2002; 17: 368-73.Slama M, Susic D, Varagic J, et al. Diastolic dysfunction in hypertension. Curr Opin Cardiol 2002; 17: 368-73.Lerman A, Gibbons RJ, Rodeheffer RJ. Circulating N-terminal atrial natriuretic peptide as a marker for symptomless left-ventricular dysfunction. Lancet 1993; 341: 1105-9.Lerman A, Gibbons RJ, Rodeheffer RJ. Circulating N-terminal atrial natriuretic peptide as a marker for symptomless left-ventricular dysfunction. Lancet 1993; 341: 1105-9.Davis M, Espiner E, Richards G, et al. Plasma brain natriuretic peptide in assessment of acute dyspnea. Lancet 1994; 343: 440-4.Davis M, Espiner E, Richards G, et al. Plasma brain natriuretic peptide in assessment of acute dyspnea. Lancet 1994; 343: 440-4.Levin RE, Gardner DG, Samson WK. Natriuretic peptides. N Engl J Med 1998; 339: 321-8.Levin RE, Gardner DG, Samson WK. Natriuretic peptides. N Engl J Med 1998; 339: 321-8.Melo LG, Pang SC, Ackermann U. Atrial natriuretic peptide: regulator of chronic arterial blood pressure. News Physiol Sci 2000; 15: 143-9.Melo LG, Pang SC, Ackermann U. Atrial natriuretic peptide: regulator of chronic arterial blood pressure. News Physiol Sci 2000; 15: 143-9.De Bold AJ, Bruneau BG, De Bold K. Mechanical and neuroendocrine regulation of the endocrine heart. Cardiovasc Res 1996; 31: 7-18.De Bold AJ, Bruneau BG, De Bold K. Mechanical and neuroendocrine regulation of the endocrine heart. Cardiovasc Res 1996; 31: 7-18.Kinnunen P, Vuolteenaho O, Ruskoah H. Mechanisms of atrial and brain natriuretic peptide release from rat ventricular myocardium: effect of stretching. Endocrinology 1993; 132: 1961-70.Kinnunen P, Vuolteenaho O, Ruskoah H. Mechanisms of atrial and brain natriuretic peptide release from rat ventricular myocardium: effect of stretching. Endocrinology 1993; 132: 1961-70.Richards AM, Crozier JG, Yandle TG, et al. Brain natriuretic factor: regional plasma concentrations and correlations with haemodynamic state in cardiac disease. Br Heart J 1993; 69: 414-7.Richards AM, Crozier JG, Yandle TG, et al. Brain natriuretic factor: regional plasma concentrations and correlations with haemodynamic state in cardiac disease. Br Heart J 1993; 69: 414-7.Haug C, Metzele A, Kochs M, et al. Plasma brain natriuretic peptide and atrial natriuretic peptide concentrations correlate with left ventricular end4diastolic pressure. Clin Cardiol 1993; 15: 553-7.Haug C, Metzele A, Kochs M, et al. Plasma brain natriuretic peptide and atrial natriuretic peptide concentrations correlate with left ventricular end4diastolic pressure. Clin Cardiol 1993; 15: 553-7.JC, Glants SA. Determinants of left ventricular filling and of the diastolic pressure-volume relaxation. Circ Res 1989; 64: 827-52.JC, Glants SA. Determinants of left ventricular filling and of the diastolic pressure-volume relaxation. Circ Res 1989; 64: 827-52.Maeda K, Tsutamoto T, Wada A, et al. Plasma brain natriuretic peptide as a biochemical marker of high left ventricular end-diastolic pressure in patients with symptomatic left ventricular dys4 function. Am Heart J 1998; 135: 825-32.Maeda K, Tsutamoto T, Wada A, et al. Plasma brain natriuretic peptide as a biochemical marker of high left ventricular end-diastolic pressure in patients with symptomatic left ventricular dys4 function. Am Heart J 1998; 135: 825-32.Iwanaga Y, Nishi I, Furuichi S, et al. B-Type Natriuretic Peptide Strongly Reflects Diastolic Wall Stress in Patients With Chronic Heart Failure. Comparison Between Systolic and Diastolic Heart Failure. JACC 2006; 47: 742-8.Iwanaga Y, Nishi I, Furuichi S, et al. B-Type Natriuretic Peptide Strongly Reflects Diastolic Wall Stress in Patients With Chronic Heart Failure. Comparison Between Systolic and Diastolic Heart Failure. JACC 2006; 47: 742-8.Hannah A, Clements S, McDonagh TA, et al. Low prevalence of isolated diastolic dysfunction in a cohort of suspected heart failure patients ant its relationship to brain natriuretic peptide. Eur Heart J 2003; 24 Abstract (Suppl.): 400.Hannah A, Clements S, McDonagh TA, et al. Low prevalence of isolated diastolic dysfunction in a cohort of suspected heart failure patients ant its relationship to brain natriuretic peptide. Eur Heart J 2003; 24 Abstract (Suppl.): 400.Lubien E., DeMaria A, Krishnaswamy P, et al. Utility of B-natriuretic peptide in detecting diastolic dysfunction. Comparison with Doppler velocity recordings. Circulation 2002; 105: 595-601.Lubien E., DeMaria A, Krishnaswamy P, et al. Utility of B-natriuretic peptide in detecting diastolic dysfunction. Comparison with Doppler velocity recordings. Circulation 2002; 105: 595-601.Thambidorai SK, Troughton RW, Parakh K, et al. Utility of B-type natriuretic peptide in primary diastolic dysfunction: a quantitative comparison with Doppler echocardiographic indices. JACC 2003; 24 Abstract (Suppl.): 400.Thambidorai SK, Troughton RW, Parakh K, et al. Utility of B-type natriuretic peptide in primary diastolic dysfunction: a quantitative comparison with Doppler echocardiographic indices. JACC 2003; 24 Abstract (Suppl.): 400.Bettencourt P, Ferreira A, Dias P, et al. Evaluation of brain natriuretic peptide in the diagnosis of heart failure. Cardiology 2000; 93: 19-21.Bettencourt P, Ferreira A, Dias P, et al. Evaluation of brain natriuretic peptide in the diagnosis of heart failure. Cardiology 2000; 93: 19-21.Yamamoto K, Burnett JCJr, Jougasaki M, et al. Superiority of brain natriuretic peptide as a hormonal marker of ventricular systolic and diastolic dysfunction and ventricular hypertrophy. Hypertension 1996; 28: 988-94.Yamamoto K, Burnett JCJr, Jougasaki M, et al. Superiority of brain natriuretic peptide as a hormonal marker of ventricular systolic and diastolic dysfunction and ventricular hypertrophy. Hypertension 1996; 28: 988-94.Yamaguchi H, Yoshida K, Sakata Y. Elevation of plasma brain natriuretic peptide is a hallmark of diastolic heart failure independent of ventricular hypertrophy. Am J Cardiol 2004; 43: 55-60.Yamaguchi H, Yoshida K, Sakata Y. Elevation of plasma brain natriuretic peptide is a hallmark of diastolic heart failure independent of ventricular hypertrophy. Am J Cardiol 2004; 43: 55-60.Schillaci G, Verdecchia P, Porcellati C, et al. Continuous relation between left ventricular mass and cardiovascular risk in essential hypertension. Hypertension 2000; 35: 580-6.Schillaci G, Verdecchia P, Porcellati C, et al. Continuous relation between left ventricular mass and cardiovascular risk in essential hypertension. Hypertension 2000; 35: 580-6.Devereux RB, Roman MJ, Liu JE, et al. Congestive heart failure despite normal left ventricular systolic function in a population-based sample: the strong heart study. Am J Cardiology 2000; 86: 1090-6.Devereux RB, Roman MJ, Liu JE, et al. Congestive heart failure despite normal left ventricular systolic function in a population-based sample: the strong heart study. Am J Cardiology 2000; 86: 1090-6.O`Connor CM, Gattis WA, Shaw L, et al. Clinical characteristics and long-term outcome of patients with heart failure and preserved systolic function. Am J Cardiol 2000; 86: 863-7.O`Connor CM, Gattis WA, Shaw L, et al. Clinical characteristics and long-term outcome of patients with heart failure and preserved systolic function. Am J Cardiol 2000; 86: 863-7.Kohno M, Horio T, Yokokawa K, et al. Brain natriuretic peptide as a cardiac hormone in essential hypertension. Am J Med 1992; 92: 29-34.Kohno M, Horio T, Yokokawa K, et al. Brain natriuretic peptide as a cardiac hormone in essential hypertension. Am J Med 1992; 92: 29-34.Luchner A, Burnett JCJr, Jougasaki M, et al. Evaluation of brain natriuretic peptide as a marker of left ventricular dysfunction and hypertrophy in the population. J Hypertens 2000; 18: 1121-8.Luchner A, Burnett JCJr, Jougasaki M, et al. Evaluation of brain natriuretic peptide as a marker of left ventricular dysfunction and hypertrophy in the population. J Hypertens 2000; 18: 1121-8.Suzuki M, Yamamoto K, Watanabe S, et al. Associates between elevated brain natriuretic peptide levels and the development of left ventricular hypertrophy in patients with essential hyperten4 sion. Am J Med 2000; 108: 627-33.Suzuki M, Yamamoto K, Watanabe S, et al. Associates between elevated brain natriuretic peptide levels and the development of left ventricular hypertrophy in patients with essential hyperten4 sion. Am J Med 2000; 108: 627-33.Nishikimi T, Yoshihara F, Morimoto A, et al. Relationship between left ventricular geometry and natriuretic peptide levels in essential hypertension. Hypertension 1996; 28: 22-30.Nishikimi T, Yoshihara F, Morimoto A, et al. Relationship between left ventricular geometry and natriuretic peptide levels in essential hypertension. Hypertension 1996; 28: 22-30.Sakata Y, Yamamoto K, Masuyama T, et al. Ventricular production of natriuretic peptides and ventricular structural remodeling in hypertensive heart failure. J Hypertens 2001; 19: 1905-12.Sakata Y, Yamamoto K, Masuyama T, et al. Ventricular production of natriuretic peptides and ventricular structural remodeling in hypertensive heart failure. J Hypertens 2001; 19: 1905-12.Mukoyama M, Nakao K, Hosoda K, et al. Brain natriuretic peptide as a novel cardiac hormone in humans: evidence for a exquisite dual natriuretic peptide system? J Clin Invest 1991; 87: 1402-12.Mukoyama M, Nakao K, Hosoda K, et al. Brain natriuretic peptide as a novel cardiac hormone in humans: evidence for a exquisite dual natriuretic peptide system? J Clin Invest 1991; 87: 1402-12.Kohno M, Minami M, Kano H, et al. Effect of angiotensin-converting enzyme inhibitor on left ventricular parameters and circulating brain natriuretic peptide in elderly hypertensives with left ventricular hypertrophy. Metabolism 2000; 49: 1356-60.Kohno M, Minami M, Kano H, et al. Effect of angiotensin-converting enzyme inhibitor on left ventricular parameters and circulating brain natriuretic peptide in elderly hypertensives with left ventricular hypertrophy. Metabolism 2000; 49: 1356-60.

The authors declare that there are no conflicts of interest present.