<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-1274</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Артериальная гипертония и сахарный диабет 2 типа: обладают ли блокаторы рецепторов ангиотензина II особыми преимуществами?</article-title><trans-title-group xml:lang="en"><trans-title>Arterial hypertension and Type 2 diabetes mellitus: any benefits for angiotensin II receptor blockers?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фомин</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Fomin</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Моисеев</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Moiseev</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сагинова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Saginova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"/><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Московская медицинская академия им. И.М. Сеченова</institution></aff><aff xml:lang="en"><institution>I.M. Sechenov Moscow Medical Academy, Moscow</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2007</year></pub-date><pub-date pub-type="epub"><day>20</day><month>06</month><year>2007</year></pub-date><volume>6</volume><issue>3</issue><fpage>126</fpage><lpage>131</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Фомин В.В., Моисеев С.В., Сагинова Е.А., 2007</copyright-statement><copyright-year>2007</copyright-year><copyright-holder xml:lang="ru">Фомин В.В., Моисеев С.В., Сагинова Е.А.</copyright-holder><copyright-holder xml:lang="en">Fomin V.V., Moiseev S.V., Saginova E.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/1274">https://cardiovascular.elpub.ru/jour/article/view/1274</self-uri><abstract><p>Блокаторы рецепторов ангиотензина II – антигипертензивные препараты, имеющие преимущества при лечении артериальной гипертонии (АГ) высокого риска. В статье представлены результаты основных клинических исследований. На примере ирбесартана обосновывается органопротективное действие этого класса препаратов для лечения АГ, ассоциированной с сахарным диабетом 2 типа.</p></abstract><trans-abstract xml:lang="en"><p>Angiotensin II receptor blockers are antihypertensive medications demonstrating some benefits in the treatment of high-risk arterial hypertension (AH). Principal clinical trials’ results are presented; organo-protective action of this drug class, with irbesartan as an example, is demonstrated for AH and Type 2 diabetes mellitus combination treatment.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>артериальная гипертония высокого риска</kwd><kwd>сахарный диабет 2 типа</kwd><kwd>блокаторы рецепторов ангиотензина II</kwd><kwd>ирбесартан</kwd></kwd-group><kwd-group xml:lang="en"><kwd>high-risk arterial hypertension</kwd><kwd>Type 2 diabetes mellitus</kwd><kwd>angiotensin II receptor blockers</kwd><kwd>irbesartan</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Zanchetti A, Hansson L, Menard J, et al. Risk assessment and treatment benefit in intensively treated hypertensive patients of the Hypertension Optimal Treatment (HOT) study for the HOT Study Group. J Hypertens 2001; 19: 819-25.</mixed-citation><mixed-citation xml:lang="en">Zanchetti A, Hansson L, Menard J, et al. Risk assessment and treatment benefit in intensively treated hypertensive patients of the Hypertension Optimal Treatment (HOT) study for the HOT Study Group. J Hypertens 2001; 19: 819-25.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Blood Pressure Lowering Treatment Trialists’ Collaboration. Effects of ACE inhibitors, calcium antagonists and other blood pressure lowering drugs: results of the prospectively designed overviews of randomized trials. Lancet 2000; 356: 1955-64.</mixed-citation><mixed-citation xml:lang="en">Blood Pressure Lowering Treatment Trialists’ Collaboration. Effects of ACE inhibitors, calcium antagonists and other blood pressure lowering drugs: results of the prospectively designed overviews of randomized trials. Lancet 2000; 356: 1955-64.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium-channel blocker vs diuretic: The Antihypertensive an Lipid-Lowering treatment to prevent Heart Attack Trial (ALLHAT). JAMA 2002; 288: 2981-97.</mixed-citation><mixed-citation xml:lang="en">The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium-channel blocker vs diuretic: The Antihypertensive an Lipid-Lowering treatment to prevent Heart Attack Trial (ALLHAT). JAMA 2002; 288: 2981-97.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">ESH-ESC Guidelines Committee. ESH-ESC guidelines for the management of arterial hypertension. J Hypertens 2003; 21: 1011-53.</mixed-citation><mixed-citation xml:lang="en">ESH-ESC Guidelines Committee. ESH-ESC guidelines for the management of arterial hypertension. J Hypertens 2003; 21: 1011-53.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Секция артериальной гипертонии ВНОК. Профилактика, диагностика и лечение артериальной гипертензии. Россий- ские рекомендации (второй пересмотр). Москва 2005.</mixed-citation><mixed-citation xml:lang="en">Секция артериальной гипертонии ВНОК. Профилактика, диагностика и лечение артериальной гипертензии. Россий- ские рекомендации (второй пересмотр). Москва 2005.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">UK Prospective Diabetes Study (UKPDS) Group. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes. Br Med J 1998; 317: 705-13.</mixed-citation><mixed-citation xml:lang="en">UK Prospective Diabetes Study (UKPDS) Group. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes. Br Med J 1998; 317: 705-13.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Pahor M, Psaty BM, Alderman MH, et al. Therapeutic benefits of ACE inhibitors and other antihypertensive drugs in patients with type 2 diabetes. Diabetes Care 2000; 23: 888-92.</mixed-citation><mixed-citation xml:lang="en">Pahor M, Psaty BM, Alderman MH, et al. Therapeutic benefits of ACE inhibitors and other antihypertensive drugs in patients with type 2 diabetes. Diabetes Care 2000; 23: 888-92.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Sowers JR, Epstein M, Frohlich ED. Diabetes, hypertension, and cardiovascular disease: an update. Hypertension 2001; 37: 1053-9.</mixed-citation><mixed-citation xml:lang="en">Sowers JR, Epstein M, Frohlich ED. Diabetes, hypertension, and cardiovascular disease: an update. Hypertension 2001; 37: 1053-9.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Zanchetti A, Ruilope LM. Antihypertensive treatment in patients with type-2 diabetes mellitus: what guidance from recent controlled randomized trials? J Hypertens 2002; 20: 2099-110.</mixed-citation><mixed-citation xml:lang="en">Zanchetti A, Ruilope LM. Antihypertensive treatment in patients with type-2 diabetes mellitus: what guidance from recent controlled randomized trials? J Hypertens 2002; 20: 2099-110.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Wolf G. Molecular mechanisms of angiotensin II in the kidney; emerging role in the progression of renal disease: beyond haemo- dynamics. Nephrol. Dial Transplant 1998; 13: 1131-42.</mixed-citation><mixed-citation xml:lang="en">Wolf G. Molecular mechanisms of angiotensin II in the kidney; emerging role in the progression of renal disease: beyond haemo- dynamics. Nephrol. Dial Transplant 1998; 13: 1131-42.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Dzau VJ. Tissue angiotensin and pathobiology of vascular dis- ease. A unifying hypothesis. Hypertension 2001; 37: 1047-52.</mixed-citation><mixed-citation xml:lang="en">Dzau VJ. Tissue angiotensin and pathobiology of vascular dis- ease. A unifying hypothesis. Hypertension 2001; 37: 1047-52.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Bottinger EP, Bitzer M. TGF β signaling in renal disease. J Am Soc Nephrol 2002; 13: 2600-10.</mixed-citation><mixed-citation xml:lang="en">Bottinger EP, Bitzer M. TGF β signaling in renal disease. J Am Soc Nephrol 2002; 13: 2600-10.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Folii F, Saad MJ, Velloso L, et al. Crosstalk between insulin and angiotensin II signaling systems. Exp Clin Endocrinol Diabetes 1999; 107: 133-9.</mixed-citation><mixed-citation xml:lang="en">Folii F, Saad MJ, Velloso L, et al. Crosstalk between insulin and angiotensin II signaling systems. Exp Clin Endocrinol Diabetes 1999; 107: 133-9.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Cottone S, Vadala A, Mangano MT, et al. Endothelium-derived factors in microalbuminuric and nonmicroalbuminuric essential hypertensives. Am J Hypertens 2000; 13: 172-6.</mixed-citation><mixed-citation xml:lang="en">Cottone S, Vadala A, Mangano MT, et al. Endothelium-derived factors in microalbuminuric and nonmicroalbuminuric essential hypertensives. Am J Hypertens 2000; 13: 172-6.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">De Jong PE, Brenner BM. From secondary to primary preven- tion of progressive renal disease: the case for screening for albu- minuria. Kidney Int 2004; 66: 2109-18.</mixed-citation><mixed-citation xml:lang="en">De Jong PE, Brenner BM. From secondary to primary preven- tion of progressive renal disease: the case for screening for albu- minuria. Kidney Int 2004; 66: 2109-18.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Stehouwer CD. Endothelial dysfunction in diabetic nephropa- thy: state of art and potential significance for non-diabetic renal disease. Nephrol Dial Transplant 2004; 19: 778-81.</mixed-citation><mixed-citation xml:lang="en">Stehouwer CD. Endothelial dysfunction in diabetic nephropa- thy: state of art and potential significance for non-diabetic renal disease. Nephrol Dial Transplant 2004; 19: 778-81.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Шестакова М.В., Кочемасова Т.В., Горелышева В.А. и др. Роль молекул адгезии (ICAM-1 и Е-селектин) в развитии диабетических микроангиопатий. Тер архив 2002; 6: 24-7.</mixed-citation><mixed-citation xml:lang="en">Шестакова М.В., Кочемасова Т.В., Горелышева В.А. и др. Роль молекул адгезии (ICAM-1 и Е-селектин) в развитии диабетических микроангиопатий. Тер архив 2002; 6: 24-7.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Шестакова М.В., Ярек-Мартынова И.Р., Иванишина Н.С. и др. Кардиоренальный синдром при сахарном диабете 1 типа: роль дисфункции эндотелия. Кардиология 2005; 6: 35-41.</mixed-citation><mixed-citation xml:lang="en">Шестакова М.В., Ярек-Мартынова И.Р., Иванишина Н.С. и др. Кардиоренальный синдром при сахарном диабете 1 типа: роль дисфункции эндотелия. Кардиология 2005; 6: 35-41.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Rosenson RS, Reasner CA. Therapeutic approaches in the prevention of cardiovascular disease in metabolic syndrome and in patients with type 2 diabetes. Curr Opin Cardiol 2004; 19: 480-7. 20. Чазова И.Е., Мычка В.Б. Метаболический синдром. Моск- ва 2004.</mixed-citation><mixed-citation xml:lang="en">Rosenson RS, Reasner CA. Therapeutic approaches in the prevention of cardiovascular disease in metabolic syndrome and in patients with type 2 diabetes. Curr Opin Cardiol 2004; 19: 480-7. 20. Чазова И.Е., Мычка В.Б. Метаболический синдром. Моск- ва 2004.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Gasic S, Wagner OF, Fasching P, et al. Fosinopril decreases levels of soluble vascular cell adhesion molecule-1 in borderline hypertensive type II diabetic patients with microalbuminuria. Am J Hypertens 1999;12(2 Pt.1): 217-22.</mixed-citation><mixed-citation xml:lang="en">Gasic S, Wagner OF, Fasching P, et al. Fosinopril decreases levels of soluble vascular cell adhesion molecule-1 in borderline hypertensive type II diabetic patients with microalbuminuria. Am J Hypertens 1999;12(2 Pt.1): 217-22.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Pahor M, Franse LV, Deitcher SR, et al. Fosinopril versus amlodipine comparative treatments study: a randomized trial to assess effects on plasminogen activator inhibitor-1. Circulation 2002; 105: 457-61.</mixed-citation><mixed-citation xml:lang="en">Pahor M, Franse LV, Deitcher SR, et al. Fosinopril versus amlodipine comparative treatments study: a randomized trial to assess effects on plasminogen activator inhibitor-1. Circulation 2002; 105: 457-61.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Шестакова М.В. Нефропротекция: роль артериального давления в прогрессировании патологии почек. Зависит ли нефропротективный эффект от выбора антигипертензивного препарата? Тер архив 2001; 6: 64-6.</mixed-citation><mixed-citation xml:lang="en">Шестакова М.В. Нефропротекция: роль артериального давления в прогрессировании патологии почек. Зависит ли нефропротективный эффект от выбора антигипертензивного препарата? Тер архив 2001; 6: 64-6.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Gertsein HC, Bosch J, Pogue J, et al. Rationale and design of a large study to evaluate the renal and cardiovascular effects of an ACE inhibitor and vitamin E in high-risk patients with diabetes: the MICRO-HOPE study. Diabetes Care 1996; 19: 1225-8.</mixed-citation><mixed-citation xml:lang="en">Gertsein HC, Bosch J, Pogue J, et al. Rationale and design of a large study to evaluate the renal and cardiovascular effects of an ACE inhibitor and vitamin E in high-risk patients with diabetes: the MICRO-HOPE study. Diabetes Care 1996; 19: 1225-8.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">The HOPE Investigators. Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. Lancet 2000; 355: 253-9.</mixed-citation><mixed-citation xml:lang="en">The HOPE Investigators. Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. Lancet 2000; 355: 253-9.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Burnier M, Brunner HR. Angiotensin II receptor antagonists. Lancet 2000; 355: 637-45.</mixed-citation><mixed-citation xml:lang="en">Burnier M, Brunner HR. Angiotensin II receptor antagonists. Lancet 2000; 355: 637-45.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Taal MW, Brenner BM. Combination ACEI and ARB therapy: additional benefit in renoprotection? Curr Opin Nephrol Hypertens 2002; 11: 377-81.</mixed-citation><mixed-citation xml:lang="en">Taal MW, Brenner BM. Combination ACEI and ARB therapy: additional benefit in renoprotection? Curr Opin Nephrol Hypertens 2002; 11: 377-81.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Швецов М.Ю., Медведева Т.Ю., Оконова Е.Б. и др. Блокаторы ангиотензиновых рецепторов 1 типа – новый класс нефропротективных препаратов. Клин фармакол тер 2002; 11(2): 62-9.</mixed-citation><mixed-citation xml:lang="en">Швецов М.Ю., Медведева Т.Ю., Оконова Е.Б. и др. Блокаторы ангиотензиновых рецепторов 1 типа – новый класс нефропротективных препаратов. Клин фармакол тер 2002; 11(2): 62-9.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Pitt B, Poole-Wilson PA, Segal R, et al. Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomized trial – The Losartan Heart Failure Survival Study ELITE II. Lancet 2000; 355: 1582-7.</mixed-citation><mixed-citation xml:lang="en">Pitt B, Poole-Wilson PA, Segal R, et al. Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomized trial – The Losartan Heart Failure Survival Study ELITE II. Lancet 2000; 355: 1582-7.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">McMurray JJV. Angiotensin II receptor antagonists for the treatment of heart failure: what is their place after ELITE-2 and Val-HeFT? JRAAS 2001; 2: 89-92.</mixed-citation><mixed-citation xml:lang="en">McMurray JJV. Angiotensin II receptor antagonists for the treatment of heart failure: what is their place after ELITE-2 and Val-HeFT? JRAAS 2001; 2: 89-92.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Lindholm L, Ibsen H, Dahlof B, et al. Cardiovascular morbidity and mortality in patients with diabetes in the Losartan Intervention For Endpoint reduction in hypertenstion study (LIFE): a randomised trial against atenolol. Lancet 2002; 359: 1004-10.</mixed-citation><mixed-citation xml:lang="en">Lindholm L, Ibsen H, Dahlof B, et al. Cardiovascular morbidity and mortality in patients with diabetes in the Losartan Intervention For Endpoint reduction in hypertenstion study (LIFE): a randomised trial against atenolol. Lancet 2002; 359: 1004-10.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Montalescot G, Collet JP. Preserving cardiac function in the hypertensive patient: why renal parameters hold the key. Eur Heart J 2005; 26(24): 2616-22.</mixed-citation><mixed-citation xml:lang="en">Montalescot G, Collet JP. Preserving cardiac function in the hypertensive patient: why renal parameters hold the key. Eur Heart J 2005; 26(24): 2616-22.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Remuzzi G, Schiepatti A, Ruggenenti P. Nephropathy in patients with type 2 diabetes mellitus. N Engl J Med 2002; 346: 1145-51.</mixed-citation><mixed-citation xml:lang="en">Remuzzi G, Schiepatti A, Ruggenenti P. Nephropathy in patients with type 2 diabetes mellitus. N Engl J Med 2002; 346: 1145-51.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Mogensen CE. The kidney in diabetes: how to control renal and related cardiovascular complications. Am J Kidney Dis 2001; 37: S2-6.</mixed-citation><mixed-citation xml:lang="en">Mogensen CE. The kidney in diabetes: how to control renal and related cardiovascular complications. Am J Kidney Dis 2001; 37: S2-6.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Шестакова М.В., Чугунова Л.А., Шамхалова М.Ш. и др. Диабетическая нефропатия: факторы риска быстрого прогрессирования почечной недостаточности. Тер архив 1999; 6: 38-41.</mixed-citation><mixed-citation xml:lang="en">Шестакова М.В., Чугунова Л.А., Шамхалова М.Ш. и др. Диабетическая нефропатия: факторы риска быстрого прогрессирования почечной недостаточности. Тер архив 1999; 6: 38-41.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Мухин Н.А., Моисеев В.С. Кардиоренальные соотношения и риск сердечно-сосудистых заболеваний. Вестник РАМН 2003; 11: 50-5.</mixed-citation><mixed-citation xml:lang="en">Мухин Н.А., Моисеев В.С. Кардиоренальные соотношения и риск сердечно-сосудистых заболеваний. Вестник РАМН 2003; 11: 50-5.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Strutz F, Bramlage P, Paar WD. Effect of three months’ treatment with irbesartan on blood and pulse pressure of hypertensive type 2 diabetic patients: open, observational study in 31,793 patients. Curr Med Res Opin 2005; 21(9): 1433-40.</mixed-citation><mixed-citation xml:lang="en">Strutz F, Bramlage P, Paar WD. Effect of three months’ treatment with irbesartan on blood and pulse pressure of hypertensive type 2 diabetic patients: open, observational study in 31,793 patients. Curr Med Res Opin 2005; 21(9): 1433-40.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Bramlage P, Pittrow D, Kirch W. The effect of irbesartan in reducing cardiovascular risk in hypertensive type 2 diabetic patients: an observational study in 16,600 patients in primary care. Curr Med Res Opin 2004; 20(10): 1625-31.</mixed-citation><mixed-citation xml:lang="en">Bramlage P, Pittrow D, Kirch W. The effect of irbesartan in reducing cardiovascular risk in hypertensive type 2 diabetic patients: an observational study in 16,600 patients in primary care. Curr Med Res Opin 2004; 20(10): 1625-31.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Parving H-H, Lehnert H, Brochner-Mortensen J, et al. The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes. N Engl J Med 2001; 345: 870-8.</mixed-citation><mixed-citation xml:lang="en">Parving H-H, Lehnert H, Brochner-Mortensen J, et al. The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes. N Engl J Med 2001; 345: 870-8.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Keane WF, Kurokawa K, Lyle PA, et al. Treatment of type 2 diabetic patients with AT1-receptors antagonists: lessons from recent trials. Clin Exp Nephrol 2002; 6: 175-81.</mixed-citation><mixed-citation xml:lang="en">Keane WF, Kurokawa K, Lyle PA, et al. Treatment of type 2 diabetic patients with AT1-receptors antagonists: lessons from recent trials. Clin Exp Nephrol 2002; 6: 175-81.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Opie LH, Parving H-H. Diabetic nephropathy. Can renoprotection be extrapolated to cardiovascular protection? Circulation 2002; 106: 643-5.</mixed-citation><mixed-citation xml:lang="en">Opie LH, Parving H-H. Diabetic nephropathy. Can renoprotection be extrapolated to cardiovascular protection? Circulation 2002; 106: 643-5.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Persson F, Rossing P, Hovind P, et al. Irbesartan treatment reduces biomarkers of inflammatory activity in patients with type 2 diabetes and microalbuminuria: an IRMA 2 substudy. Diabetes 2006; 55(12): 3550-5.</mixed-citation><mixed-citation xml:lang="en">Persson F, Rossing P, Hovind P, et al. Irbesartan treatment reduces biomarkers of inflammatory activity in patients with type 2 diabetes and microalbuminuria: an IRMA 2 substudy. Diabetes 2006; 55(12): 3550-5.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Llewelyn DE, Garcia-Puig J. How different urinary albumin excretion rates can predict progression to nephropathy and the effect of treatment in hypertensive diabetics. J Renin Angiotensin Aldosterone Syst 2004; 5(3): 141-5.</mixed-citation><mixed-citation xml:lang="en">Llewelyn DE, Garcia-Puig J. How different urinary albumin excretion rates can predict progression to nephropathy and the effect of treatment in hypertensive diabetics. J Renin Angiotensin Aldosterone Syst 2004; 5(3): 141-5.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Rossing K, Christensen PK, Andersen S, et al. Comparative effects of Irbesartan on ambulatory and office blood pressure: a substudy of ambulatory blood pressure from the Irbesartan in Patients with Type 2 Diabetes and Microalbuminuria study. Diabetes Care 2003; 26(3): 569-74.</mixed-citation><mixed-citation xml:lang="en">Rossing K, Christensen PK, Andersen S, et al. Comparative effects of Irbesartan on ambulatory and office blood pressure: a substudy of ambulatory blood pressure from the Irbesartan in Patients with Type 2 Diabetes and Microalbuminuria study. Diabetes Care 2003; 26(3): 569-74.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Andersen S, Brochner-Mortensen J, Parving HH; Irbesartan in Patients With Type 2 Diabetes and Microalbuminuria Study Group. Kidney function during and after withdrawal of long-term irbesartan treatment in patients with type 2 diabetes and microalbuminuria. Diabetes Care 2003; 26(12): 3296-302.</mixed-citation><mixed-citation xml:lang="en">Andersen S, Brochner-Mortensen J, Parving HH; Irbesartan in Patients With Type 2 Diabetes and Microalbuminuria Study Group. Kidney function during and after withdrawal of long-term irbesartan treatment in patients with type 2 diabetes and microalbuminuria. Diabetes Care 2003; 26(12): 3296-302.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Komajada M. Are angiotensin II receptor blockers indicated in chronic heart failure? Heart 2002; 87: 1-2.</mixed-citation><mixed-citation xml:lang="en">Komajada M. Are angiotensin II receptor blockers indicated in chronic heart failure? Heart 2002; 87: 1-2.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Беленков Ю.Н., Мареев В.Ю. Как мы лечим больных с сердечно-сосудистыми заболеваниями в реальной клинической практике. Тер архив 2003; 8: 5-11.</mixed-citation><mixed-citation xml:lang="en">Беленков Ю.Н., Мареев В.Ю. Как мы лечим больных с сердечно-сосудистыми заболеваниями в реальной клинической практике. Тер архив 2003; 8: 5-11.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Palmer AJ, Rodby RA. Health economics studies assessing irbesartan use in patients with hypertension, type 2 diabetes, and microalbuminuria. Kidney Int Suppl 2004; (92): S118-20.</mixed-citation><mixed-citation xml:lang="en">Palmer AJ, Rodby RA. Health economics studies assessing irbesartan use in patients with hypertension, type 2 diabetes, and microalbuminuria. Kidney Int Suppl 2004; (92): S118-20.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Palmer AJ, Annemans L, Roze S, et al. Cost-effectiveness of early irbesartan treatment versus control (standard antihypertensive medications excluding ACE inhibitors, other angiotensin-2 receptor antagonists, and dihydropyridine calcium channel blockers) or late irbesartan treatment in patients with type 2 diabetes, hypertension, and renal disease. Diabetes Care 2004; 27(8): 1897-903.</mixed-citation><mixed-citation xml:lang="en">Palmer AJ, Annemans L, Roze S, et al. Cost-effectiveness of early irbesartan treatment versus control (standard antihypertensive medications excluding ACE inhibitors, other angiotensin-2 receptor antagonists, and dihydropyridine calcium channel blockers) or late irbesartan treatment in patients with type 2 diabetes, hypertension, and renal disease. Diabetes Care 2004; 27(8): 1897-903.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Бойцов С.А. Изучение патогенеза гипертонической болезни продолжается. Тер архив 2005; 9: 5-12.</mixed-citation><mixed-citation xml:lang="en">Бойцов С.А. Изучение патогенеза гипертонической болезни продолжается. Тер архив 2005; 9: 5-12.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Rossing K, Schjoedt KJ, Jensen BR, et al. Enhanced renoprotective effects of ultrahigh doses of irbesartan in patients with type 2 diabetes and microalbuminuria. Kidney Int 2005; 68(3): 1190-8.</mixed-citation><mixed-citation xml:lang="en">Rossing K, Schjoedt KJ, Jensen BR, et al. Enhanced renoprotective effects of ultrahigh doses of irbesartan in patients with type 2 diabetes and microalbuminuria. Kidney Int 2005; 68(3): 1190-8.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Мычка В.Б., Мамырбаева К.М., Масенко В.П. и др. Возможности антигипертензивной терапии ирбесартаном в коррекции инсулинорезистентности и нарушений мозгового кровотока у больных с метаболическим синдромом. Сons Med 2006; 8(11): 25-30.</mixed-citation><mixed-citation xml:lang="en">Мычка В.Б., Мамырбаева К.М., Масенко В.П. и др. Возможности антигипертензивной терапии ирбесартаном в коррекции инсулинорезистентности и нарушений мозгового кровотока у больных с метаболическим синдромом. Сons Med 2006; 8(11): 25-30.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Lindholm LH, Ibsen H, Borch-Jornsen K, et al. Risk of newonset diabetes in the Losartan Intervention For Endpoint reduction in hypertension study. J Hypertens 2002; 20: 1879-86.</mixed-citation><mixed-citation xml:lang="en">Lindholm LH, Ibsen H, Borch-Jornsen K, et al. Risk of newonset diabetes in the Losartan Intervention For Endpoint reduction in hypertension study. J Hypertens 2002; 20: 1879-86.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Schupp M, Pharm B, Janke J, et al. Angiotensin type 1 receptor blockers induce peroxisome proliferators-activated receptor-? activity. Circulation 2004; 109: 2054-7.</mixed-citation><mixed-citation xml:lang="en">Schupp M, Pharm B, Janke J, et al. Angiotensin type 1 receptor blockers induce peroxisome proliferators-activated receptor-? activity. Circulation 2004; 109: 2054-7.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
