cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLCcardiovascular-1292Research ArticleДИСЛИПИДЕМИИ И ИШЕМИЧЕСКАЯ БОЛЕЗНЬ СЕРДЦАБезопасность и эффективность применения розувастатина у больных ишемической болезнью сердцаRosuvastatin safety and efficacy in coronary heart disease patientsСергиенкоИ. В.SergienkoI. V.igor@cardioline.ruЕжовМ. В.EzhovM. V.МасенкоВ. П.MasenkoV. P.Российский кардиологический научно-производственный комплекс Росздрава. МоскваRussian Cardiology Scientific and Clinical Complex, State Federal Agency for Health and Social Development. Moscow200620102006552731Copyright © Сергиенко И.В., Ежов М.В., Масенко В.П., 20062006Сергиенко И.В., Ежов М.В., Масенко В.П.Sergienko I.V., Ezhov M.V., Masenko V.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/1292

Цель. Изучить влияние розувастатина на липидный спектр (ЛС) больных ишемической болезнью сердца (ИБС) и определить безопасность препарата. Материал и методы. В исследование включены 30 мужчин (средний возраст 57±9 лет) с диагнозом ИБС: стабильная стенокардия напряжения II-III функциональных классов с подобранной основной терапией. У всех больных содержание общего холестерина (ОХС) > 5,2 ммоль/л. Пациентам был назначен розувастатин в дозе 10 мг / сут. До начала и через три месяца приема розувастатина регистрировались электрокардиограмма, определялись общий и биохимический анализы крови для изучения ЛС. С целью оценки безопасности приема розувастатина оценивали уровни аспартатаминотрансферазы, аланинаминотрансферазы, креатинкиназы, глюкозы, общего билирубина, креатинина. Результаты. Отмечено положительное влияние 3-месячной терапии розувастатином на ЛС крови: концентрации ОХС, триглицеридов (ТГ) и ХС липопротеинов низкой плотности (ЛНП) достоверно снизились, а уровень ХС липопротеинов высокой плотности (ЛВП) повысился. В целом отмечено снижение концентрации ОХС на 31%, ТГ – 39%, ХС ЛНП – 44% и повышение ХС ЛВП – 6%. Достижения целевых уровней ОХС удалось добиться у 17 больных (57%), ХС ЛНП – у 23 больных (77%). На протяжении всего исследования побочные реакции не отмечены. Отсутствовало достоверно значимое изменение содержания в крови печеночных трансаминаз, креатинкиназы, билирубина и глюкозы. Заключение. Розувастатин не повышает риск рабдомиолиза и миопатий. Назначение этого препарата позволяет добиваться значимого снижения ОХС и ХС ЛНП.

Aim. To study rosuvastatin safety and effects on lipid profile (LP) in coronary heart disease (CHD) patients. Material and methods. The study included 30 males (mean age 57±9 years) with diagnosed CHD, Functional Class II-III stable effort angina, receiving adequate basic therapy. In all participants, initial total cholesterol (TCH) level was >5,2 mmol/l. At baseline and after three weeks of rosuvastatin therapy (10 mg/d), general and biochemical blood assays were performed, to measure LP, AST, ALT, creatine kinase (CK), glucose, total bilirubin (BR) and creatinine levels. Results. Three-month rosuvastatin therapy improved blood LP: TCH, triglyceride (TG) and low-density lipoprotein CH (LDL-CH) levels significantly reduced, and high-density lipoprotein CH (HDL-CH) level increased. In general, levels of TCH decreased by 31%, TG – by 39%, LDL-CH – by 44%, and HDL-CH level increased by 6%. Target TCH level was achieved in 17 participants (57%), and target LDL-CH level – in 23 patients (77%). Throughout the study, no adverse reactions (hepatic enzymes, CK, BR, or glucose level increase) were observed. Conclusion. Rosuvastatin did not increase rhabdomyolysis or myopathy risk. Rosuvastatin therapy helped to achieve significant decrease in TCH and LDL-CH levels.

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The authors declare that there are no conflicts of interest present.