cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLCcardiovascular-1296Research ArticleОБЗОРЫREVIEWSПрогностическая роль эндотелиальной дисфункции при кардиоваскулярной патологииEndothelial dysfunction prognostic role in cardiovascular pathologyРоманенкоТ. С.RomanenkoT. S.nkonzevaya@gnicpm.ruОмельяненкоМ. Г.OmelyanenkoM. G.nkonzevaya@gnicpm.ruКонцеваяА. В.KontsevayaA. V.nkonzevaya@gnicpm.ruИвановская государственная медицинская академия, ИвановоIvanovo State Medical Academy, IvanovoГосударственный научно-исследовательский центр профилактической медицины, МоскваState Research Center for Preventive Medicine, Moscow20082010200875116121Copyright © Романенко Т.С., Омельяненко М.Г., Концевая А.В., 20082008Романенко Т.С., Омельяненко М.Г., Концевая А.В.Romanenko T.S., Omelyanenko M.G., Kontsevaya A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/1296

Эндотелиальная дисфункция (ЭД) усиливает воздействие патогенетических факторов риска (ФР) поражения сосудов и напрямую связана с механизмами развития атеросклероза и его осложнений. Для уточнения прогностической роли ЭД был выполнен сравнительный анализ работ по этому вопросу с использованием различных методов оценки эндотелиальной функции (ЭФ). Исследования, анализирующие ЭФ, продемонстрировали четкую взаимосвязь ЭД с различными клиническими исходами сердечно-сосудистых заболеваний (ССЗ). В настоящее время основным методом определения вероятности развития различных сердечно-сосудистых событий в ближайшие 5–10 лет у больных ССЗ и у лиц без клинической манифестации ССЗ, является оценка суммарного риска смерти. Можно предположить, что ЭД является независимым маркером атеросклеротического процесса даже при его субклиническом течении и может служить предвестником различных сердечно-сосудистых событий. Вероятно, эндотелий выступает в роли необходимого связующего звена между любым ФР и его отрицательным влиянием на сосудистую стенку. Оценка ЭФ может широко использоваться для динамического наблюдения за пациентами в качестве одного из показателей эффективности профилактических вмешательств, что предстоит подтвердить в ходе дальнейших научных исследований.

Endothelial dysfunction (ED) amplifies the effects of vascular risk factors (RF), and is directly linked to pathogenetic mechanisms of atherosclerosis and its complications. To clarify ED prognostic role, a review of relevant studies was performed. ED interrelation with various clinical outcomes of cardiovascular disease (CVD) was demonstrated. At the moment, the main method of 5-10-year CVD risk assessment in CVD patients and asymptomatic individuals is evaluation of total mortality risk. ED could be an independent marker of atherosclerosis, including its subclinica course, and a predictor of various CVD events. Endothelium may link various RF and their damaging effect on vascular wall. Future studies will confirm whether endothelial function assessment could be used for dynamic follow-up of CVD patients, as a measure of prevention effectiveness.

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The authors declare that there are no conflicts of interest present.