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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-1313</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МНЕНИЕ ПО ПРОБЛЕМЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OPINION ON A PROBLEM</subject></subj-group></article-categories><title-group><article-title>Рефрактерная стенокардия: что мы можем предложить пациенту?</article-title><trans-title-group xml:lang="en"><trans-title>Refractory angina: what to offer to our patients?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Терещенко</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Tereshchenko</surname><given-names>S. N.</given-names></name></name-alternatives><email xlink:type="simple">stereschenko@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жиров</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhirov</surname><given-names>I. V.</given-names></name></name-alternatives><email xlink:type="simple">stereschenko@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Московский государственный медицинский университет, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow State Medical University, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2007</year></pub-date><pub-date pub-type="epub"><day>20</day><month>08</month><year>2007</year></pub-date><volume>6</volume><issue>4</issue><fpage>103</fpage><lpage>106</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Терещенко С.Н., Жиров И.В., 2007</copyright-statement><copyright-year>2007</copyright-year><copyright-holder xml:lang="ru">Терещенко С.Н., Жиров И.В.</copyright-holder><copyright-holder xml:lang="en">Tereshchenko S.N., Zhirov I.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/1313">https://cardiovascular.elpub.ru/jour/article/view/1313</self-uri><abstract><p>Рефрактерная стенокардия – сравнительно редкое состояние, которое, тем не менее, является актуальной проблемой современной кардиологии. В статье приведены определения этого заболевания, даны алгоритмы диагностики и терапии. Особое внимание уделено вопросам модулирования метаболизма в миокарде как патогенетического способа фармакотерапии рефрактерной стенокардии.</p></abstract><trans-abstract xml:lang="en"><p>Refractory angina is a relatively rare state that nevertheless remains an important problem in modern cardiology. The article contains its definitions, diagnostics and management algorithms. The emphasis is put on myocardial metabolism modulation as pathogenetic method of refractory angina pharmacotherapy.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>хроническая рефрактерная стенокардия</kwd><kwd>эпидемиология</kwd><kwd>диагностика</kwd><kwd>лечение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chronic refractory angina</kwd><kwd>epidemiology</kwd><kwd>diagnostics</kwd><kwd>treatment</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Chester MR. Chronic refractory angina. Br J Cardiol 2000; 7: 108-11.</mixed-citation><mixed-citation xml:lang="en">Chester MR. Chronic refractory angina. Br J Cardiol 2000; 7: 108-11.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Лупанов В.П. Диагностика и лечение рефрактерной стенокардии. РМЖ 2004; 12: 104-7.</mixed-citation><mixed-citation xml:lang="en">Лупанов В.П. Диагностика и лечение рефрактерной стенокардии. РМЖ 2004; 12: 104-7.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Mannheimer C, Camici P, Chester M, et al. The problem of chronic refractory angina; report from the ESC Joint Study Group on the Treatment of Refractory Angina.Eur Heart J 2002; 23: 355-70.</mixed-citation><mixed-citation xml:lang="en">Mannheimer C, Camici P, Chester M, et al. The problem of chronic refractory angina; report from the ESC Joint Study Group on the Treatment of Refractory Angina.Eur Heart J 2002; 23: 355-70.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Whitlow P, Dimas A, Bashore T, et al. Relationship of extent of revascularization with angina at one year in the Bypass Angioplasty Revascularization Investigation (BARI). JACC 1999; 34: 1750-9.</mixed-citation><mixed-citation xml:lang="en">Whitlow P, Dimas A, Bashore T, et al. Relationship of extent of revascularization with angina at one year in the Bypass Angioplasty Revascularization Investigation (BARI). JACC 1999; 34: 1750-9.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">CABRI Trial Participants. First-year results of CABRI (Coronary Angioplasty versus Bypass Revascularisation Investigation). Lancet 1995; 346: 1179-84.</mixed-citation><mixed-citation xml:lang="en">CABRI Trial Participants. First-year results of CABRI (Coronary Angioplasty versus Bypass Revascularisation Investigation). Lancet 1995; 346: 1179-84.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Moore R, Groves D, Nolan J, et al. Altered short term heart rate variability with spinal cord stimulation in chronic refractory angina: evidence for the presence of procedure related cardiac sympathetic blockade. Heart 2004; 90: 211-2.</mixed-citation><mixed-citation xml:lang="en">Moore R, Groves D, Nolan J, et al. Altered short term heart rate variability with spinal cord stimulation in chronic refractory angina: evidence for the presence of procedure related cardiac sympathetic blockade. Heart 2004; 90: 211-2.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Randle P, Garland P, Hales C, et al. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1963; 1: 785-9.</mixed-citation><mixed-citation xml:lang="en">Randle P, Garland P, Hales C, et al. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1963; 1: 785-9.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Crozatier B, Badoual T, Boehm E, et al. Role of creatine kinase in cardiac excitation-contraction coupling: studies in creatine kinase-deficient mice. FASEB J 2002; 16: 653-60.</mixed-citation><mixed-citation xml:lang="en">Crozatier B, Badoual T, Boehm E, et al. Role of creatine kinase in cardiac excitation-contraction coupling: studies in creatine kinase-deficient mice. FASEB J 2002; 16: 653-60.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Weiss RG, Chatham G, Georgakopoulos D, et al. An increase in the myocardial PCr/ATP ratio in GLUT4 null mice. FASEB J 2002; 16: 613-5.</mixed-citation><mixed-citation xml:lang="en">Weiss RG, Chatham G, Georgakopoulos D, et al. An increase in the myocardial PCr/ATP ratio in GLUT4 null mice. FASEB J 2002; 16: 613-5.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Ingwall JS. Transgenesis and cardiac energetics: new insights into cardiac metabolism. J Mol Cell Cardiol 2004; 37: 613-23.</mixed-citation><mixed-citation xml:lang="en">Ingwall JS. Transgenesis and cardiac energetics: new insights into cardiac metabolism. J Mol Cell Cardiol 2004; 37: 613-23.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Belke DD, Betuing S, Tuttle G, et al. Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression. J Clin Invest 2002; 109: 629-39.</mixed-citation><mixed-citation xml:lang="en">Belke DD, Betuing S, Tuttle G, et al. Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression. J Clin Invest 2002; 109: 629-39.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Watanabe K, Fujii H, Katakashi T, et al. Constitutive regulation of cardiac fatty acid metabolism through peroxisome proliferator-activated receptor alpha associated with age-dependent cardiac toxicity. J Biol Chem 2000; 275: 2293-9.</mixed-citation><mixed-citation xml:lang="en">Watanabe K, Fujii H, Katakashi T, et al. Constitutive regulation of cardiac fatty acid metabolism through peroxisome proliferator-activated receptor alpha associated with age-dependent cardiac toxicity. J Biol Chem 2000; 275: 2293-9.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Kantor P, Lucien A, Kozak P, et al. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Cir Res 2000; 86: 580-8.</mixed-citation><mixed-citation xml:lang="en">Kantor P, Lucien A, Kozak P, et al. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Cir Res 2000; 86: 580-8.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Vladimir I. Influencing myocardial energy metabolism as a therapeutic principle. Clin Drug Invest 2004; 24: 731-8.</mixed-citation><mixed-citation xml:lang="en">Vladimir I. Influencing myocardial energy metabolism as a therapeutic principle. Clin Drug Invest 2004; 24: 731-8.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Detry J, Sellier P, Pennaforte S, et al. Trimetazidine: a new concept in the treatment of angina. Comparison with propranolol in patients with stable angina. Trimetazidine European Multicenter Study Group. Br J Clin Pharmacol 1994; 37: 279-88.</mixed-citation><mixed-citation xml:lang="en">Detry J, Sellier P, Pennaforte S, et al. Trimetazidine: a new concept in the treatment of angina. Comparison with propranolol in patients with stable angina. Trimetazidine European Multicenter Study Group. Br J Clin Pharmacol 1994; 37: 279-88.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Kolbel F, Bada V. Trimetazidine in geriatric patients with stable angina pectoris: the TIGER study. Int J Clin Pract 2003; 57: 867- 70.</mixed-citation><mixed-citation xml:lang="en">Kolbel F, Bada V. Trimetazidine in geriatric patients with stable angina pectoris: the TIGER study. Int J Clin Pract 2003; 57: 867- 70.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Chaitman B, Scettino S, Parker J, et al. Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina. JACC 2004; 43: 1375-82.</mixed-citation><mixed-citation xml:lang="en">Chaitman B, Scettino S, Parker J, et al. Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina. JACC 2004; 43: 1375-82.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Opie LH. The Heart. 3rd Ed. Philadelphia, Pa: Lippincott-Raven 1998.</mixed-citation><mixed-citation xml:lang="en">Opie LH. The Heart. 3rd Ed. Philadelphia, Pa: Lippincott-Raven 1998.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Kates A, Herrero P, Dence C, et al. Impact of aging on substrate metabolism by the human heart. JAСC 2003; 41: 293-9.</mixed-citation><mixed-citation xml:lang="en">Kates A, Herrero P, Dence C, et al. Impact of aging on substrate metabolism by the human heart. JAСC 2003; 41: 293-9.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Davila-Roman V, Vidala G, Herrero P, et al. Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy. JACC 2002; 40: 271-7.</mixed-citation><mixed-citation xml:lang="en">Davila-Roman V, Vidala G, Herrero P, et al. Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy. JACC 2002; 40: 271-7.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Fisher DJ. Oxygenation and metabolism in the developing heart. Semin Perinatol 1984; 8: 217-25.</mixed-citation><mixed-citation xml:lang="en">Fisher DJ. Oxygenation and metabolism in the developing heart. Semin Perinatol 1984; 8: 217-25.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Razeghi P, Young M, Alcorn J, et al. Metabolic gene expression in fetal and failing human heart. Circulation 2001; 104: 2923-31.</mixed-citation><mixed-citation xml:lang="en">Razeghi P, Young M, Alcorn J, et al. Metabolic gene expression in fetal and failing human heart. Circulation 2001; 104: 2923-31.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
