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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-1321</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МНЕНИЕ ПО ПРОБЛЕМЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OPINION ON A PROBLEM</subject></subj-group></article-categories><title-group><article-title>Торасемид – петлевой диуретик с особыми свойствами</article-title><trans-title-group xml:lang="en"><trans-title>Torasemide – loop diuretic with specific effects</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Горбунов</surname><given-names>В. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Gorbunov</surname><given-names>V. M.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Оганов</surname><given-names>Р. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Oganov</surname><given-names>R. G.</given-names></name></name-alternatives><email xlink:type="simple">oganov@online.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Государственный научно-исследовательский центр профилактической медицины Росздрава. Москва<country>Россия</country></aff><aff xml:lang="en">State Research Center for Preventive Medicine, State Federal Agency for Health and Social Development. Moscow<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2006</year></pub-date><pub-date pub-type="epub"><day>20</day><month>10</month><year>2006</year></pub-date><volume>5</volume><issue>5</issue><fpage>70</fpage><lpage>74</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Горбунов В.М., Оганов Р.Г., 2006</copyright-statement><copyright-year>2006</copyright-year><copyright-holder xml:lang="ru">Горбунов В.М., Оганов Р.Г.</copyright-holder><copyright-holder xml:lang="en">Gorbunov V.M., Oganov R.G.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/1321">https://cardiovascular.elpub.ru/jour/article/view/1321</self-uri><abstract><p>Петлевой диуретик торасемид характеризуется высокой биодоступностью и пролонгированным эффектом, что обуславливает ряд благоприятных фармакодинамических свойств препарата. Торасемид обладает выраженным антигипертензивным эффектом; его можно использовать у больных артериальной гипертонией как в виде монотерапии, так и в комбинации с другими антигипертензивными средствами. Преимущества торасемида перед фуросемидом при лечении пациентов с хронической сердечной недостаточностью, в т.ч. в плане прогноза, были доказаны в крупных исследованиях. Фармакокинетические свойства торасемида практически не изменяются при хронической печеночной и почечной недостаточности. Побочные эффекты препарата количественно и качественно сопоставимы с таковыми у других диуретиков. Все это делает торасемид достойным более широкого применения в современной, клинической практике.</p></abstract><trans-abstract xml:lang="en"><p>A loop diuretic torasemide is characterized by high bioavailability and prolonged action, explaining some beneficial pharmacodynamic features of the medication. Demonstrating a clear antihypertensive effect, torasemide can be used as monotherapy or combined with other antihypertensives. Torasemide benefits, comparing to furosemide, in chronic heart failure treatment have been confirmed in numerous large-scale studies. Its pharmacokynetics remains virtually unchanged in patients with chronic liver or renal failure. Adverse effects are similar to those in other diuretics, by both quality and quantity. Therefore, torasemide can be used more widely in modern clinical practice.</p><p> </p></trans-abstract><kwd-group xml:lang="ru"><kwd>хроническая сердечная недостаточность</kwd><kwd>артериальная гипертония</kwd><kwd>петлевые диуретики</kwd><kwd>торасемид</kwd><kwd>фурасемид</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Chronic heart failure</kwd><kwd>arterial hypertension</kwd><kwd>loop diuretics</kwd><kwd>torasemide</kwd><kwd>furosemide</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Метелица В.И. Справочник по клинической фармакологии сердечно-сосудистых лекарственных средств. 3-е издание. Москва 2005; 1527 с.</mixed-citation><mixed-citation xml:lang="en">Метелица В.И. Справочник по клинической фармакологии сердечно-сосудистых лекарственных средств. 3-е издание. 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