cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLCcardiovascular-1327Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEW ARTICLESК вопросу патогенеза болезней системы кровообращенияCirculatory disease pathogenesisВоробьеваЕ. Н.VorobyevaE. N.elenavorobyova@yandex.ruОсиповаИ. В.OsipovaI. V.ВоробьевР. И.VorobyevR. I.ТрешутинаЮ. В.TreshutinaYu. V.Алтайский государственный медицинский университет. БарнаулAltay State Medical University. Barnaul,20062010200655114120Copyright © Воробьева Е.Н., Осипова И.В., Воробьев Р.И., Трешутина Ю.В., 20062006Воробьева Е.Н., Осипова И.В., Воробьев Р.И., Трешутина Ю.В.Vorobyeva E.N., Osipova I.V., Vorobyev R.I., Treshutina Y.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/1327

Обзор посвящен биологической роли активных форм кислорода (АФК), которые конститутивно генерируются в различных клетках здоровых организмов, от одноклеточных до высокоорганизованных, выполняя, благодаря высокой химической реактивности и весьма короткой продолжительности жизни, важную функцию сигнальных внутриклеточных трансдукторов и межклеточных медиаторов для реализации срочной и отсроченной адаптивной перестройки тканевого метаболизма, в т.ч. в системе кровообращения. При значительном накоплении в организме таких молекул их медиаторная функция трансформируется в повреждающую, обусловленную окислением и разрушением тканевых липидов, белков и нуклеиновых кислот с развитием патологических повреждений. Эта концепция согласуется с многочисленными клиническими сообщениями о том, что у больных эссенциальной гипертонией, атеросклерозом, ишемической болезнью сердца и инфарктом миокарда тканевой и плазменный уровень АФК и продуктов окислительного повреждения клеточных биополимеров во много раз выше величин, наблюдаемых у здоровых людей даже в период экстремальных ситуаций; патогенетически значимыми в данном случае выступает локальная и/или системная гиперпродукция супероксидных и гидроксильных радикалов, гидропероксида, оксида азота, пероксинитрита и других АФК.

The review is devoted to biological role of reactive oxygen forms, generated in various cells of all healthy organisms, and performing, due to their high chemical reactivity and short lifetime, vital function of signal intracellular transduction and intercellular mediation, realizing immediate and delayed adaptation of tissue metabolism, circulatory system included. In excessive amount of these molecules, their moderating function transforms into damaging oxidation and destruction of tissue lipids, proteins and nucleic acids. This concept is supported by numerous clinical data on substantial increase in tissue and plasma levels of active oxygen forms and oxidative cellular biopolymer damage products among patients with essential arterial hypertension, atheroscleroisis, coronary heart disease and myocardial infarction. The leading pathogenetic role is played by local and/or systemic hyperproduction of superoxide and hydroxide radicals, hydroperoxide, NO, peroxinitrite and other active oxygen forms.

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The authors declare that there are no conflicts of interest present.