cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLCcardiovascular-1389Research ArticleАРТЕРИАЛЬНАЯ ГИПЕРТОНИЯARTERIAL HYPERTENSIONПолиморфизм гена фактора некроза опухолей альфа у больных эссенциальной артериальной гипертензиейTumor necrosis factor alpha gene polymorphism in patients wiht essential hypertensionТимашеваЯ. Р.TimashevaY. R.НасибуллинТ. Р.NasibullinT. R.ЗакироваА. Н.ZakirovaA. N.МустафинаО. Е.MustafinaO. E.Институт биохимии и генетики Уфимского научного центра Российской академии наукInstitute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of ScienceГОУ ВПО Башкирский государственный медицинский университет, УфаBashkir State Medical University, Ufa2007201220076659Copyright © Тимашева Я.Р., Насибуллин Т.Р., Закирова А.Н., Мустафина О.Е., 20072007Тимашева Я.Р., Насибуллин Т.Р., Закирова А.Н., Мустафина О.Е.Timasheva Y.R., Nasibullin T.R., Zakirova A.N., Mustafina O.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/1389

Цель. Провести анализ ассоциаций -308G/A полиморфизма гена фактора некроза опухолей альфа (TNFА) с эссенциальной артериальной гипертензией (ЭАГ). Материал и методы. В исследование были включены 354 пациента с ЭАГ и 295 здоровых людей. Дезоксирибонуклеиновую кислоту выделяли из венозной крови. Генотипирование проводили методом полимеразной цепной реакции в сочетании с рестрикционным анализом ампликонов. Результаты. Частота генотипа TNFА -308*G/*G среди больных ЭАГ, перенесших инсульт, была значительно ниже, чем в контрольной группе – 60,98% vs 78,98% (p=0,015). У больных ЭАГ с генотипом TNFА -308*G/*G понижен относительный риск развития инсульта. Заключение. Полученные результаты позволяют предположить, что полиморфизм -308G/A гена TNFА вносит вклад в развитие инсульта у больных ЭАГ.

Aim. To analyze the association between tumor necrosis factor-alpha gene –308 G/A polymorphism and essential arterial hypertension (EAH). Material and methods. The study included 354 EAH patients and 295 age-matched healthy subjects. DNA was extracted from venous blood. Genotyping was performed using polymerase chain reaction followed by restriction amplicon analysis. Results. TNFA -308*G/*G genotype frequency was significantly lower among EAH patients with stroke than in control group (60,98% vs 78,98%; p=0,015). EAH patients with TNFA -308 *G/*G genotype had lower stroke risk (OR=0,38; 95% CI: 0,21-0,83). Conclusion. The results obtained suggest that TNFA gene -308G/A polymorphism is involved in stroke pathogenesis among EAH patients.

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The authors declare that there are no conflicts of interest present.