cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLCcardiovascular-1404Research ArticleИШЕМИЧЕСКАЯ БОЛЕЗНЬ СЕРДЦАCORONARY HEART DISEASEГиполипидемическая эффективность и безопасность генерического ловастатинаHypolipidemic effectiveness and safety of generic lovastatinАроновД. М.AronovD. M.КухарчукВ. В.KukharchukV. V.КукесВ. Г.KukesV. G.БубноваМ. Г.BubnovaM. G.Государственный научно-исследовательский центр профилактической медицины РосздраваState Research Center for Preventive Medicine, State Federal Agency for Health and Social DevelopmentНИИ клинической кардиологии им. А.Л. Мясникова РК НПК РосздраваA.L. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical Complex, State Federal Agency for Health and Social DevelopmentМосковская медицинская академия им. И.М.Сеченова Росздрава. МоскваI.M. Sechenov Moscow Medical Academy, State Federal Agency for Health and Social Development. Moscow200620122006564652Copyright © Аронов Д.М., Кухарчук В.В., Кукес В.Г., Бубнова М.Г., 20062006Аронов Д.М., Кухарчук В.В., Кукес В.Г., Бубнова М.Г.Aronov D.M., Kukharchuk V.V., Kukes V.G., Bubnova M.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/1404

Цель. Изучить гиполипидемическую эффективность и безопасность генерического ловастатина (Кардиостатин®). Материал и методы. В открытое, кооперативное исследование включены 90 больных ишемической болезнью сердца с гиперхолестеринемией до 10 ммоль / л. Больные получали Кардиостатин® в дозах 20 мг / сут., далее при необходимости 40 мг / сут. и 80 мг / сут. Исследовали динамику содержания в сыворотке крови общего холестерина, холестерина липопротеидов низкой плотности (ХС ЛНП), холестерина липопротеидов высокой плотности, триглицеридов и печеночных ферментов. Изучали изменения уровней С-реактивного белка (СРБ) в крови. Результаты. Кардиостатин® влияет на уровень липидных фракций крови в тех же пределах, что и оригинальный ловастатин. Целевой уровень ХС ЛНП (<2,5 ммоль / л) достигнут у 68,8% больных. У пациентов с повышенным уровнем СРБ произошло достоверное снижение этого показателя. Заключение. Кардиостатин® обладает выраженными гиполипидемическими свойствами и снижает повышенный уровень СРБ. Кардиостатин® может быть рекомендован для лечения дислипидемий и заболеваний атеросклеротического генеза.

Aim. To study hypolipidemic effectiveness and safety of generic lovastatin (Cardiostatin®). Material and methods. This open, cooperative study included 90 patients with coronary heart disease (CHD) and hypercholesterolemia (<10 mmol/l). All patients received Cardiostatin® in the dose of 20 mg/d, increased up to 40-80 mg/d, if needed. Dynamics of total cholesterol (TCH), low-density lipoprotein CH (LDL-CH), high-density lipoprotein CH (HDL-CH), triglycerides, hepatic enzymes, and C-reactive protein (CRP) levels was studied. Results. Cardiostatin® improved lipid profile to the same extent as original lovastatin. Target TCH level (<2,5 mmol/l) was achieved in 68,8% of the patients. In participants with initially increased CRP level, it had significantly reduced. Conclusion. Cardiostatin® demonstrated good hypolipidemic effects, at the same time reducing increased CRP level. Cardiostatin can be recommended for dyslipidemia and atherosclerotic pathology treatment.

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The authors declare that there are no conflicts of interest present.