cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLCcardiovascular-1412Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEW ARTICLESВозможности и эффекты применения эфиров растительных станолов в немедикаментозной профилактике сердечно-сосудистых заболеваний, обусловленных атеросклерозомPlant stanol ethers: perspectives and effects in non-pharmaceutical prevention of atherosclerotic cardiovascular pathologyПероваН. В.PerovaN. V.oganov@online.ruГосударственный научно-исследовательский центр профилактической медицины Росздрава. МоскваState Research Center for Preventive Medicine, State Federal Agency for Health and Social Development. Moscow20062012200656108115Copyright © Перова Н.В., 20062006Перова Н.В.Perova N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/1412

Действие пищевых продуктов, обогащенных эфирами растительных станолов (ЭРС), по снижению уровня общего холестерина (ОХС) и ХС наиболее атерогенных липопротеидов низкой плотности (ЛНП) обусловлено ингибированием абсорбции ХС энтероцитами из просвета кишечника. ЭРС тормозят абсорбцию как пищевого, так и билиарного ХС. Эстерифицированные ненасыщенными жирными кислотами станолы хорошо растворяются как в высокожировых продуктах (спреды), так и в низкожировых (молоко, кефир, йогурты и др.). Эффективно снижающими уровни ХС в плазме крови и ХС ЛНП дозами ЭРС являются дозы 1,6-2,8 г/сут.; степень снижения ОХС 7-10%, ХС ЛНП 12-15%. При использовании продуктов, обогащенных ЭРС у лиц с гиперхолестеринемией (ГХС) на фоне лечения ингибиторами синтеза ХС – статинами, степень снижения уровня ХС ЛНП увеличивается на 10-20%. «Функциональные» продукты, содержащие ЭРС, могут быть широко использованы для немедикаментозного лечения ГХС и для профилактики сердечно-сосудистых заболеваний среди широких слоев населения.

Reduction in total cholesterol (TCH) and low-density lipoprotein CH (LDL-CH) levels while taking food products enriched in plant stanol ethers (PSE) might be explained by inhibited intestine enterocyte CH absorption. PSE inhibit both food and biliary CH absorption. Unsaturated fatty acid-etherized stanols are well-soluble in high-fat foods (spreads), as well as in low-fat products (milk, kefir, yogurts, etc.). Serum TCH and LDL-CH levels are effectively reduced (by 7-10% and 12-15%, respectively) with PSE doses of 1,6-2,8 g/d. In hypercholesterolemia (HCH) patients receiving CH synthesis inhibitors – statins, PSE-enriched food intake associates with additional LDL-CH decrease by 10-20%. PSE-enriched “functional” products might be widely used for non-pharmaceutical HCH treatment and cardiovascular prevention on population level.

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The authors declare that there are no conflicts of interest present.