cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLCcardiovascular-1413Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEW ARTICLESСтенокардия Принцметала. Новый взгляд на патогенез и подходы к лечениюPrinzmetal angina: new approaches to pathogenesis and treatmentФоминаИ. Г.FominaI. G.resp.tab@inbox.ruМатвеевВ. В.MatveevV. V.resp.tab@inbox.ruГаланинаН. А.GalaninaN. A.resp.tab@inbox.ruПерскаяЕ. Л.PerskayaE. L.resp.tab@inbox.ruМосковская медицинская академия им. И.М. Сеченова. МоскваI.M. Sechenov Moscow Medical Academy. Moscow20062012200656116122Copyright © Фомина И.Г., Матвеев В.В., Галанина Н.А., Перская Е.Л., 20062006Фомина И.Г., Матвеев В.В., Галанина Н.А., Перская Е.Л.Fomina I.G., Matveev V.V., Galanina N.A., Perskaya E.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/1413

В статье представлены современные сведения об этиологии и патогенезе вазоспастической стенокардии с указанием наиболее вероятных генетических факторов заболевания, влияния нейрогуморальных факторов. Особое внимание уделено роли фермента Rho-киназы в механизмах коронароспазма; с патогенетических позиций освещены новые медикаментозные подходы к терапии стенокардии Принцметала, а также возможности ее хирургического лечения.

The article contains modern data on vasospastic angina ethiology and pathogenesis, discussing possible genetic and neuro-humoral factors. Rho-kinase role in coronary spasm mechanisms is emphasized. New pharmaceutical approaches to Prinzmetal angina treatment, as well as perspectives of its surgery correction, are reviewed.

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The authors declare that there are no conflicts of interest present.