<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-1418</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МНЕНИЕ ПО ПРОБЛЕМЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OPINION ON A PROBLEM</subject></subj-group></article-categories><title-group><article-title>Сердечно-сосудистые заболевания и ингибиторы ангиотензин-превращающего фермента: фокус на эналаприл</article-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular disease and ACE inhibitors: focusing on enalapril</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Барышникова</surname><given-names>Г. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Baryshnikova</surname><given-names>G. A.</given-names></name></name-alternatives><bio xml:lang="ru"/><email xlink:type="simple">bargalan@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГУ «Учебно-научный медицинский центр» Управления делами Президента Российской Федерации, Москва</institution></aff><aff xml:lang="en"><institution>Teaching and Research Medical Center, RF President Administration, Moscow</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2007</year></pub-date><pub-date pub-type="epub"><day>20</day><month>12</month><year>2007</year></pub-date><volume>6</volume><issue>6</issue><fpage>69</fpage><lpage>74</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Барышникова Г.А., 2007</copyright-statement><copyright-year>2007</copyright-year><copyright-holder xml:lang="ru">Барышникова Г.А.</copyright-holder><copyright-holder xml:lang="en">Baryshnikova G.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/1418">https://cardiovascular.elpub.ru/jour/article/view/1418</self-uri><abstract><p>Эналаприл – один из наиболее хорошо и всесторонне изученных ингибиторов ангиотензин-превращающего фермента (ИАПФ), доказавший свою высокую эффективность при лечении артериальной гипертонии, хронической сердечной недостаточности и дисфункции левого желудочка, в т.ч. после перенесенного инфаркта миокарда. Одним из лучших дженериков эналаприла является Берлиприл® – ИАПФ с уникальной структурой, обеспечивающей 100% биодоступность действующего вещества.</p></abstract><trans-abstract xml:lang="en"><p>Enalapril is one of the best-studied ACE inhibitors, demonstrating high effectiveness in treating arterial hypertension, chronic heart failure, and left ventricular dysfunction, including that after myocardial infarction. One of the best enalapril generics is Berlipril® – an ACE inhibitor with unique structure, providing 100% bioavailability of the active agent.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ингибиторы ангиотензин-превращающего фермента</kwd><kwd>эналаприл</kwd><kwd>артериальная гипертония</kwd><kwd>органопротективное действие</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ACE inhibitors</kwd><kwd>enalapril</kwd><kwd>arterial hypertension</kwd><kwd>organo-protective action</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Scheen AJ. Renin-angiotensin system inhibition prevents type 2 diabetes mellitus. Part 1. A meta-analysis of randomised clinical trials. Diabetes Metab 2004; 30(6): 487-96.</mixed-citation><mixed-citation xml:lang="en">Scheen AJ. Renin-angiotensin system inhibition prevents type 2 diabetes mellitus. Part 1. A meta-analysis of randomised clinical trials. Diabetes Metab 2004; 30(6): 487-96.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Wing LM, Reid CM, Ryan P, et al. A comparison of outcomes with angiotensin-converting-enzyme inhibitors and diuretics for hypertension in the elderly. N Engl J Med 2003; 348(7): 583-92.</mixed-citation><mixed-citation xml:lang="en">Wing LM, Reid CM, Ryan P, et al. A comparison of outcomes with angiotensin-converting-enzyme inhibitors and diuretics for hypertension in the elderly. N Engl J Med 2003; 348(7): 583-92.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">The CONSENSUS Trial Study Group. Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian enalapril survival study (CONSENSUS). N Engl J Med 1987; 316: 1429-35.</mixed-citation><mixed-citation xml:lang="en">The CONSENSUS Trial Study Group. Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian enalapril survival study (CONSENSUS). N Engl J Med 1987; 316: 1429-35.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">The SOLVD Investigators. Effect of enalapril on survival in patients with reduced left ventricular ejection fraction and congestive heart failure. N Engl J Med 1991; 325: 293-302.</mixed-citation><mixed-citation xml:lang="en">The SOLVD Investigators. Effect of enalapril on survival in patients with reduced left ventricular ejection fraction and congestive heart failure. N Engl J Med 1991; 325: 293-302.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">The SOLVD Investigators. Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. N Engl J Med 1992; 327: 685-91.</mixed-citation><mixed-citation xml:lang="en">The SOLVD Investigators. Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. N Engl J Med 1992; 327: 685-91.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Jong P, Yusuf S, Rousseau MF, et al. Effect of enalapril on 12-year survival and life expectancy in patients with left ventricular systolic dysfunction: a follow-up study. Lancet 2003; 361(9372): 1843-8.</mixed-citation><mixed-citation xml:lang="en">Jong P, Yusuf S, Rousseau MF, et al. Effect of enalapril on 12-year survival and life expectancy in patients with left ventricular systolic dysfunction: a follow-up study. Lancet 2003; 361(9372): 1843-8.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Loeb HS, Johnson G, Henrick A, et al. Effect of enalapril, hydralazine plus isosorbide dinitrate, and prazosin on hospitalization in patients with chronic congestive heart failure. The V- HeFT VA Cooperative Studies Group. Circulation 1993; 87(6 Suppl): VI78-87.</mixed-citation><mixed-citation xml:lang="en">Loeb HS, Johnson G, Henrick A, et al. Effect of enalapril, hydralazine plus isosorbide dinitrate, and prazosin on hospitalization in patients with chronic congestive heart failure. The V- HeFT VA Cooperative Studies Group. Circulation 1993; 87(6 Suppl): VI78-87.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Garg R, Yusuf S. Overview of randomized trials of angiotensin-converting enzyme inhibitors on mortality and morbidity in patients with heart failure. Collaborative Group on ACE Inhibitor Trials. JAMA 1995; 273(18): 1450-6.</mixed-citation><mixed-citation xml:lang="en">Garg R, Yusuf S. Overview of randomized trials of angiotensin-converting enzyme inhibitors on mortality and morbidity in patients with heart failure. Collaborative Group on ACE Inhibitor Trials. JAMA 1995; 273(18): 1450-6.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Luzier AB, Forrest A, Adelman M, et al. Impact of angiotensin-converting enzyme inhibitor underdosing on rehospitalization rates in congestive heart failure. Am J Cardiol 1998; 82(4): 465-9.</mixed-citation><mixed-citation xml:lang="en">Luzier AB, Forrest A, Adelman M, et al. Impact of angiotensin-converting enzyme inhibitor underdosing on rehospitalization rates in congestive heart failure. Am J Cardiol 1998; 82(4): 465-9.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Foy SG, Crozier IG, Turner JG, et al. Comparison of enalapril versus captopril on left ventricular function and survival three months after acute myocardial infarction (the «PRACTICAL» study). Am J Cardiol 1994; 73(16): 1180-6.</mixed-citation><mixed-citation xml:lang="en">Foy SG, Crozier IG, Turner JG, et al. Comparison of enalapril versus captopril on left ventricular function and survival three months after acute myocardial infarction (the «PRACTICAL» study). Am J Cardiol 1994; 73(16): 1180-6.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Ravid M, Lang R, Rachmani R, Lishner M. Long-term renoprotective effect of angiotensin-converting enzyme inhibition in non-insulin-dependent diabetes mellitus. A 7-year follow-up study. Arch Intern Med 1996; 156(3): 286-9.</mixed-citation><mixed-citation xml:lang="en">Ravid M, Lang R, Rachmani R, Lishner M. Long-term renoprotective effect of angiotensin-converting enzyme inhibition in non-insulin-dependent diabetes mellitus. A 7-year follow-up study. Arch Intern Med 1996; 156(3): 286-9.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Шестакова М.В. Ингибиторы ангиотензин-превращающего фермента и патология почек: непревзойденный нефропротективный эффект. Cons Med 2002; 4(3): 134-6.</mixed-citation><mixed-citation xml:lang="en">Шестакова М.В. Ингибиторы ангиотензин-превращающего фермента и патология почек: непревзойденный нефропротективный эффект. Cons Med 2002; 4(3): 134-6.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Vermes E, Tardif JC, Bourassa MG, et al. Enalapril reduces the incidence of diabetes in patients with chronic heart failure: insight from the Studies Of Left Ventricular Dysfunction (SOLVD). Circulation 2003; 107(9): 1291-6.</mixed-citation><mixed-citation xml:lang="en">Vermes E, Tardif JC, Bourassa MG, et al. Enalapril reduces the incidence of diabetes in patients with chronic heart failure: insight from the Studies Of Left Ventricular Dysfunction (SOLVD). Circulation 2003; 107(9): 1291-6.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Vermes E, Tardif JC, Bourassa MG, et al. Enalapril reduces the incidence of atrial fibrillation in patients with chronic heart failure: insight from the Studies Of Left Ventricular Dysfunction (SOLVD). Circulation 2003; 107(9): 2926-31.</mixed-citation><mixed-citation xml:lang="en">Vermes E, Tardif JC, Bourassa MG, et al. Enalapril reduces the incidence of atrial fibrillation in patients with chronic heart failure: insight from the Studies Of Left Ventricular Dysfunction (SOLVD). Circulation 2003; 107(9): 2926-31.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Tabacova SA, Kimmel CA. Enalapril: pharmacokinetic/dynamic inferences for comparative developmental toxicity. A review; Reproductive Toxicology 2001; 15: 467-78.</mixed-citation><mixed-citation xml:lang="en">Tabacova SA, Kimmel CA. Enalapril: pharmacokinetic/dynamic inferences for comparative developmental toxicity. A review; Reproductive Toxicology 2001; 15: 467-78.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
