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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-1495</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW ARTICLES</subject></subj-group></article-categories><title-group><article-title>Клиническая, липид-нормализующая и плейотропная эффективность розувастатина; обзор серии исследований GALAXY</article-title><trans-title-group xml:lang="en"><trans-title>Clinical, lipid-lowering, and pleiotropic effectiveness of rosuvastatin: a review of the GALAXY programme results</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бритов</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Britov</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"/><email xlink:type="simple">abritov@gnicpm.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чупина</surname><given-names>М. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Chupina</surname><given-names>M. P.</given-names></name></name-alternatives><bio xml:lang="ru"/><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГУ Государственный научно-исследовательский центр профилактической медицины</institution></aff><aff xml:lang="en"><institution>State Research Centre for Preventive Medicine</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>20</day><month>02</month><year>2011</year></pub-date><volume>10</volume><issue>1</issue><fpage>104</fpage><lpage>109</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бритов А.Н., Чупина М.П., 2011</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="ru">Бритов А.Н., Чупина М.П.</copyright-holder><copyright-holder xml:lang="en">Britov A.N., Chupina M.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/1495">https://cardiovascular.elpub.ru/jour/article/view/1495</self-uri><abstract><p>В статье представлен обзор результатов законченной международной программы GALAXY, представляющей собой серию клинических, как правило, сравнительных исследований, сопоставляющих различные статины. Эти исследования показали преимущество розувастатина в нормализации показателей липидного обмена, маркеров воспаления и обратного развития атеросклероза в коронарных артериях и магистральных артериях головы. Лекарственные формы розувастатина весьма перспективны для профилактики тяжелых органных поражений у больных атеросклерозом на всех стадиях его развития.</p></abstract><trans-abstract xml:lang="en"><p>The paper reviews the results of the GALAXY international programme, a series of clinical (mostly comparative) studies of various statins. It has demonstrated the benefits of rosuvastatin in terms of normalization of lipid profile, inflammatory markers, and coronary or cerebrovascular atherosclerosis regression. This makes rosuvastatin medications promising for the prevention of severe organ complications at all atherosclerosis stages.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>статины</kwd><kwd>розувастатин</kwd><kwd>липид-снижающее и плейотропное действия</kwd><kwd>международная программа GALAXY</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Statins</kwd><kwd>rosuvastatin</kwd><kwd>lipid-lowering and pleiotropic effects</kwd><kwd>GALAXY international programme</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ross R. The pathogenesis of atherosclerosis — an update. N Engl J Med 1986; 314: 488-500.</mixed-citation><mixed-citation xml:lang="en">Ross R. The pathogenesis of atherosclerosis — an update. N Engl J Med 1986; 314: 488-500.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ross R. 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