cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLCcardiovascular-1518Research ArticleМНЕНИЕ ПО ПРОБЛЕМЕOPINION ON A PROBLEMАгрессивная терапия статинами при остром коронарном синдроме, возможности аторвастатина в суточной дозе 80 мгAggressive statin therapy in acute coronary syndrome: therapeutic potential of atorvastatin in the daily dose of 80 mgБритовА. Н.BritovA. N.

Ведущий научный сотрудник отдела разработки клинических методов вторичной профилактики.

Москва

Moscow

anbrinov@yandex.ruФГУ Государственный научно-исследовательский центр профилактической медицины РосмедтехнологииState Research Centre for Preventive Medicine, Federal Agency on High Medical Technologies200920122009868287Copyright © Бритов А.Н., 20092009Бритов А.Н.Britov A.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/1518

Представлен критический обзор исследований последних лет, доказывающих целесообразность назначения статинов в больших дозах, в частности аторвастатина, больным коронарной болезнью сердца (КБС) и очень высоким риском жизнеугрожающих коронарных событий. Недавние плацебо-контолируемые и сравнительные исследования со статинами в высоких дозах, например, аторвастатином в дозе 80 мг/сут., у больных со стабильной КБС или с острым коронарным синдромом (ОКС) продемонстрировали дозозависимый эффект препарата, особенно в первые месяцы после ОКС и инфаркта миокарда.

The paper reviews recent studies justifying high-dose statin therapy (in particular, atorvastatin treatment) in patients with coronary heart disease (CHD) and high risk of life-threatening coronary events. In the latest placebo- controlled and comparative studies of high statin doses (e.g., 80 mg/d of atorvastatin) in stable CHD or acute coronary syndrome (ACS), a dose-depended effect of statins has been demonstrated, especially during the first months after ACS and myocardial infarction.

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The authors declare that there are no conflicts of interest present.