cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLCcardiovascular-1521Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEW ARTICLESРоль низкомолекулярных гепаринов при тромболитической терапии у больных инфарктом миокардаLow-molecular heparins in thrombolytic therapy of myocardial infarction patientsЯвеловИ. С.YavelovI. S.

Профессор кафедры клинической фармакологии с курсом клинической кардиологии и фармакокинетики.

Moscow

yavelov@yahoo.comГОУ ВПО Российский государственный медицинский университетState Research Medical University University20092012200986111122Copyright © Явелов И.С., 20092009Явелов И.С.Yavelov I.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/1521

В настоящее время стандартным дополнением к тромболитической терапии (ТЛТ) при инфаркте миокарда рассматривают парентеральное введение антикоагулянтов. В обзоре анализируются результаты клинических исследований, доказавших преимущество подкожного введения низкомолекулярного гепарина эноксапарина в течение 1 недели перед 48-часовой внутривенной инфузией нефракционированного гепарина, ставшие основой для современных представлений об оптимальном применении гепарина в случаях, когда для восстановления кровотока по окклюзированной коронарной артерии исполь­зуется ТЛТ.

Currently, parenteral anticoagulant therapy is considered a standard addition to thrombolytic treatment (TLT) in myocardial infarction (MI). This review analyses the results of the clinical trials demonstrating the benefits of subcutaneous low-molecular heparin enoxaparin therapy (one week before 48-hour intravenous infusion of unfractionated heparin). This evidence influenced the modern views on optimal heparin therapy in TLT-based coronary revascularisation.

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The authors declare that there are no conflicts of interest present.