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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-1618</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LITERATURE REVIEW</subject></subj-group></article-categories><title-group><article-title>Мочевая кислота – ключевой компонент “кардиоренометаболического континуума”</article-title><trans-title-group xml:lang="en"><trans-title>Uric acid – the key component of “cardio-reno-metabolic continuum”</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кобалава</surname><given-names>Ж. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Kobalava</surname><given-names>Zh. D.</given-names></name></name-alternatives><email xlink:type="simple">Kotovskaya@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Котовская</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kotovskaya</surname><given-names>Yu. V.</given-names></name></name-alternatives><email xlink:type="simple">Kotovskaya@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Толкачева</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tolkacheva</surname><given-names>V. V.</given-names></name></name-alternatives><email xlink:type="simple">Kotovskaya@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мильто</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Milto</surname><given-names>A. S.</given-names></name></name-alternatives><email xlink:type="simple">Kotovskaya@bk.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский университет дружбы народов</institution></aff><aff xml:lang="en"><institution>Russian University of People’s Friendship</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Городская клиническая больница № 64 г. Москвы</institution></aff><aff xml:lang="en"><institution>Moscow City Clinical Hospital No. 64. Moscow</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2008</year></pub-date><pub-date pub-type="epub"><day>20</day><month>08</month><year>2008</year></pub-date><volume>7</volume><issue>4</issue><fpage>95</fpage><lpage>100</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кобалава Ж.Д., Котовская Ю.В., Толкачева В.В., Мильто А.С., 2008</copyright-statement><copyright-year>2008</copyright-year><copyright-holder xml:lang="ru">Кобалава Ж.Д., Котовская Ю.В., Толкачева В.В., Мильто А.С.</copyright-holder><copyright-holder xml:lang="en">Kobalava Z.D., Kotovskaya Y.V., Tolkacheva V.V., Milto A.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/1618">https://cardiovascular.elpub.ru/jour/article/view/1618</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>мочевая кислота</kwd><kwd>риск развития сердечно-сосудистых осложнений</kwd><kwd>артериальная гипертония</kwd><kwd>метаболический синдром</kwd></kwd-group><kwd-group xml:lang="en"><kwd>uric acid</kwd><kwd>cardiovascular event risk</kwd><kwd>arterial hypertension</kwd><kwd>metabolic syndrome</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Моисеев B.C., Кобалава Ж.Д.. Кардиоренальный синдром (почечный фактор и повышение риска сердечно-сосудистых заболеваний). Клин фармак тер 2002; 11(3): 16-8.</mixed-citation><mixed-citation xml:lang="en">Моисеев B.C., Кобалава Ж.Д.. Кардиоренальный синдром (почечный фактор и повышение риска сердечно-сосудистых заболеваний). Клин фармак тер 2002; 11(3): 16-8.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Мухин Н.А., Моисеев С.В., Кобалава Ж.Д. и др. Кардиоренальные взаимодействия: клиническое значение и роль в патогенезе заболеваний сердечно-сосудистой системы и почек. Тер архив 2004; 6: 39-46.</mixed-citation><mixed-citation xml:lang="en">Мухин Н.А., Моисеев С.В., Кобалава Ж.Д. и др. Кардиоренальные взаимодействия: клиническое значение и роль в патогенезе заболеваний сердечно-сосудистой системы и почек. Тер архив 2004; 6: 39-46.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Тареев Е.М. Гипертоническая болезнь. Москва "Медицина" 1948.</mixed-citation><mixed-citation xml:lang="en">Тареев Е.М. Гипертоническая болезнь. Москва "Медицина" 1948.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Кобалава Ж.Д., Котовская Ю.В. Артериальная гипертония: основные положения современных руководств. Москва 2005; 96 с.</mixed-citation><mixed-citation xml:lang="en">Кобалава Ж.Д., Котовская Ю.В. Артериальная гипертония: основные положения современных руководств. Москва 2005; 96 с.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Guidelines Committee. 2003 European Society of Hypertension-European Society of Cardiology guidelines for the management of arterial hypertension. J Hypertension 2003; 21: 1011-53.</mixed-citation><mixed-citation xml:lang="en">Guidelines Committee. 2003 European Society of Hypertension-European Society of Cardiology guidelines for the management of arterial hypertension. J Hypertension 2003; 21: 1011-53.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Профилактика, диагностика и лечение артериальной гипертензии. Российские рекомендации, 2-й пересмотр, www.cardiosite.ru</mixed-citation><mixed-citation xml:lang="en">Профилактика, диагностика и лечение артериальной гипертензии. Российские рекомендации, 2-й пересмотр, www.cardiosite.ru</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Mancia G., De Backer G., Dominiczak A., et al. 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2007; 25: 1105-87.</mixed-citation><mixed-citation xml:lang="en">Mancia G., De Backer G., Dominiczak A., et al. 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2007; 25: 1105-87.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Johnson R.J., Kang D-H., Feig D., et al. Is There a Pathogenetic Role for Uric Acid in Hypertension and Cardiovascular and Renal Disease? Hypertension 2003; 41: 1183-90.</mixed-citation><mixed-citation xml:lang="en">Johnson R.J., Kang D-H., Feig D., et al. Is There a Pathogenetic Role for Uric Acid in Hypertension and Cardiovascular and Renal Disease? Hypertension 2003; 41: 1183-90.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Johnson R.J., Feig D.I., Nakagawa T., et al. Pathogenesis of essential hypertension: historical paradigms and modern insights. J Hypertens 2008; 26: 381-91.</mixed-citation><mixed-citation xml:lang="en">Johnson R.J., Feig D.I., Nakagawa T., et al. Pathogenesis of essential hypertension: historical paradigms and modern insights. J Hypertens 2008; 26: 381-91.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Бугаева Н.В., Балкаров И.М. Артериальная гипертония и нарушение пуринового обмена. Тер архив 1996; 68(1): 36-9.</mixed-citation><mixed-citation xml:lang="en">Бугаева Н.В., Балкаров И.М. Артериальная гипертония и нарушение пуринового обмена. Тер архив 1996; 68(1): 36-9.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Мухин Н.А, Балкаров И.М., Моисев С.В. и др. Хронические прогрессирующие нефропатии и образ жизни современного человека. Тер архив 2004; 9: 5–10.</mixed-citation><mixed-citation xml:lang="en">Мухин Н.А, Балкаров И.М., Моисев С.В. и др. Хронические прогрессирующие нефропатии и образ жизни современного человека. Тер архив 2004; 9: 5–10.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Johnson RJ, Kivlighn SD, Kim YG, et al. Reappraisal of the Pathogenesis and consequences of hyperuricemia in hypertension, cardiovascular disease, and renal disease. Am J Kid Dis 1999; 33: 225–34.</mixed-citation><mixed-citation xml:lang="en">Johnson RJ, Kivlighn SD, Kim YG, et al. Reappraisal of the Pathogenesis and consequences of hyperuricemia in hypertension, cardiovascular disease, and renal disease. Am J Kid Dis 1999; 33: 225–34.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Kang DH, Park SK, Lee IK, Johnson RJ. Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells. J Am Soc Nephrol 2005; 16: 3553–62.</mixed-citation><mixed-citation xml:lang="en">Kang DH, Park SK, Lee IK, Johnson RJ. Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells. J Am Soc Nephrol 2005; 16: 3553–62.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Khosla UM, Zharikov S, Finch JL, et al. Hyperuricemia induces endothelial dysfunction. Kidney Int 2005; 67: 1739–42.</mixed-citation><mixed-citation xml:lang="en">Khosla UM, Zharikov S, Finch JL, et al. Hyperuricemia induces endothelial dysfunction. Kidney Int 2005; 67: 1739–42.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Mazzali M, Kanellis J, Han L, et al. Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressureindependent mechanism. Am J Physiol Renal Physiol 2002; 282: F991–7.</mixed-citation><mixed-citation xml:lang="en">Mazzali M, Kanellis J, Han L, et al. Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressureindependent mechanism. Am J Physiol Renal Physiol 2002; 282: F991–7.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Watanabe S, Kang DH, Feng L, et al. Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity. Hypertension 2002; 40: 355–60.</mixed-citation><mixed-citation xml:lang="en">Watanabe S, Kang DH, Feng L, et al. Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity. Hypertension 2002; 40: 355–60.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Nakagawa T, Hu H, Zharikov S, et al. A causal role for uric acid in fructose-induced metabolic syndrome. Am J Physiol Renal Physiol 2006; 290: F625–31.</mixed-citation><mixed-citation xml:lang="en">Nakagawa T, Hu H, Zharikov S, et al. A causal role for uric acid in fructose-induced metabolic syndrome. Am J Physiol Renal Physiol 2006; 290: F625–31.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Johnson RJ, Titte S, Cade JR, et al. Uric acid, evolution and primitive cultures. Semin Nephrol 2005; 25: 3–8.</mixed-citation><mixed-citation xml:lang="en">Johnson RJ, Titte S, Cade JR, et al. Uric acid, evolution and primitive cultures. Semin Nephrol 2005; 25: 3–8.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Jossa F, Farinaro E, Panico S, et al. Serum uric acid and hypertension: the Olivetti heart study. J Hum Hypertens 1994; 8: 677–81.</mixed-citation><mixed-citation xml:lang="en">Jossa F, Farinaro E, Panico S, et al. Serum uric acid and hypertension: the Olivetti heart study. J Hum Hypertens 1994; 8: 677–81.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Masuo K, Kawaguchi H, Mikami H, et al. Serum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevation. Hypertension 2003; 42: 474–80.</mixed-citation><mixed-citation xml:lang="en">Masuo K, Kawaguchi H, Mikami H, et al. Serum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevation. Hypertension 2003; 42: 474–80.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Sundstrom J, Sullivan L, D’Agostino RB, et al. Relations of serum uric acid to longitudinal blood pressure tracking and hypertension incidence. Hypertension 2005; 45: 28–33.</mixed-citation><mixed-citation xml:lang="en">Sundstrom J, Sullivan L, D’Agostino RB, et al. Relations of serum uric acid to longitudinal blood pressure tracking and hypertension incidence. Hypertension 2005; 45: 28–33.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Feig DI, Nakagawa T, Karumanchi SA, et al. Hypothesis: uric acid, nephron number, and the pathogenesis of essential hypertension. Kidney Int 2004; 66: 281–7.</mixed-citation><mixed-citation xml:lang="en">Feig DI, Nakagawa T, Karumanchi SA, et al. Hypothesis: uric acid, nephron number, and the pathogenesis of essential hypertension. Kidney Int 2004; 66: 281–7.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Sautin YY, Nakagawa T, Zharikov S, Johnson RJ. Adverse effects of the classical antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress. Am J Physiol Cell Physiol 2007; 293: C584–96.</mixed-citation><mixed-citation xml:lang="en">Sautin YY, Nakagawa T, Zharikov S, Johnson RJ. Adverse effects of the classical antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress. Am J Physiol Cell Physiol 2007; 293: C584–96.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Puig GJ, Ruilope LM. Uric acid as a cardiovascular risk factor in arterial hypertension. J Hypertens 1999; 17: 869–72.</mixed-citation><mixed-citation xml:lang="en">Puig GJ, Ruilope LM. Uric acid as a cardiovascular risk factor in arterial hypertension. J Hypertens 1999; 17: 869–72.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Кобалава Ж.Д., Котовская Ю.В., Толкачева В.В., Караулова Ю.Л. Мочевая кислота-маркер и/или новый фактор рискаразвития сердечно-сосудистых осложнений? Клин фармак тер 2002; 11(3): 32–9.</mixed-citation><mixed-citation xml:lang="en">Кобалава Ж.Д., Котовская Ю.В., Толкачева В.В., Караулова Ю.Л. Мочевая кислота-маркер и/или новый фактор рискаразвития сердечно-сосудистых осложнений? Клин фармак тер 2002; 11(3): 32–9.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Gertler MM, Garn SM, Levine SA. Serum uric acid in relation to age and physique in health and in coronary heart disease. Ann Intern Med 1951; 34: 1421–31.</mixed-citation><mixed-citation xml:lang="en">Gertler MM, Garn SM, Levine SA. Serum uric acid in relation to age and physique in health and in coronary heart disease. Ann Intern Med 1951; 34: 1421–31.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Fessel WJ. High uric acid as an indicator of cardiovascular disease. Independence from obesity. Am J Med 1980; 68: 401–4.</mixed-citation><mixed-citation xml:lang="en">Fessel WJ. High uric acid as an indicator of cardiovascular disease. Independence from obesity. Am J Med 1980; 68: 401–4.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Campion EW, Glynn RJ, DeLabry LO. Asymptomatic hyperuricemia. Risks and consequences in the normative aging study. Am J Med 1987; 82: 421–6.</mixed-citation><mixed-citation xml:lang="en">Campion EW, Glynn RJ, DeLabry LO. Asymptomatic hyperuricemia. Risks and consequences in the normative aging study. Am J Med 1987; 82: 421–6.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Alderman MH. Serum Uric Acid As a Cardiovascular Risk Factor for Heart Disease. Current Hypertens Reports 2001, 3: 184–9.</mixed-citation><mixed-citation xml:lang="en">Alderman MH. Serum Uric Acid As a Cardiovascular Risk Factor for Heart Disease. Current Hypertens Reports 2001, 3: 184–9.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Fang J, Alderman MN. Serum uric acid and cardiovascular mortality – The NHANES 1 Epidemiologic Follow-up Study 1971–1992. JAMA 2000; 283: 2404–10.</mixed-citation><mixed-citation xml:lang="en">Fang J, Alderman MN. Serum uric acid and cardiovascular mortality – The NHANES 1 Epidemiologic Follow-up Study 1971–1992. JAMA 2000; 283: 2404–10.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Levine W, Dyer AR, Shekelle RB, et al. Serum uric acid and 11.5-year mortality of middle-aged women: findings of the Chicago Heart Association Detection Project in Industry. J Clin Epidemiol 1989; 42: 257–67.</mixed-citation><mixed-citation xml:lang="en">Levine W, Dyer AR, Shekelle RB, et al. Serum uric acid and 11.5-year mortality of middle-aged women: findings of the Chicago Heart Association Detection Project in Industry. J Clin Epidemiol 1989; 42: 257–67.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Moriarity JT, Folsom AR, Iribarren C, et al. Serum uric acid and risk of coronary heart disease: atherosclerosis risk in communities (ARIC) Study. Ann Epidemiol 2000; 10: 136–43.</mixed-citation><mixed-citation xml:lang="en">Moriarity JT, Folsom AR, Iribarren C, et al. Serum uric acid and risk of coronary heart disease: atherosclerosis risk in communities (ARIC) Study. Ann Epidemiol 2000; 10: 136–43.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Verdecchia P, Schillaci G, Reboldi GP, et al. The relation between serum uric acid and risk of cardiovascular disease in essential hypertension. The PIUMA study. Hypertension 2000; 36: 1072–8.</mixed-citation><mixed-citation xml:lang="en">Verdecchia P, Schillaci G, Reboldi GP, et al. The relation between serum uric acid and risk of cardiovascular disease in essential hypertension. The PIUMA study. Hypertension 2000; 36: 1072–8.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Langford HG, Blaufox MD, Borhani NO, et al. Is thiazideproduced uric acid elevation harmful? Analysis of data from the Hypertension Detection and Follow-up Program. Arch Intern Med 1987; 147: 645–9.</mixed-citation><mixed-citation xml:lang="en">Langford HG, Blaufox MD, Borhani NO, et al. Is thiazideproduced uric acid elevation harmful? Analysis of data from the Hypertension Detection and Follow-up Program. Arch Intern Med 1987; 147: 645–9.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Alderman MH, Cohen H, Madhavean S, Kivlighn S. Serum uric acid and cardiovascular events in successfully treated hypertensive patients. Hypertension 1999; 34: 144–50.</mixed-citation><mixed-citation xml:lang="en">Alderman MH, Cohen H, Madhavean S, Kivlighn S. Serum uric acid and cardiovascular events in successfully treated hypertensive patients. Hypertension 1999; 34: 144–50.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Franse LV, Pahor M, DiBari M, et al. Serum uric acid, diuretic treatment and risk of cardiovascular events in the Systolic Hypertension in the Elderly Program (SHEP). J Hypertens 2000; 18: 1149–54.</mixed-citation><mixed-citation xml:lang="en">Franse LV, Pahor M, DiBari M, et al. Serum uric acid, diuretic treatment and risk of cardiovascular events in the Systolic Hypertension in the Elderly Program (SHEP). J Hypertens 2000; 18: 1149–54.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Chamorro A, Obach V, Cervera A, et al. Prognostic significance of uric acid serum concentration in patients with acute ischemic stroke. Stroke 2002; 33: 1048–52.</mixed-citation><mixed-citation xml:lang="en">Chamorro A, Obach V, Cervera A, et al. Prognostic significance of uric acid serum concentration in patients with acute ischemic stroke. Stroke 2002; 33: 1048–52.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker versus diuretic: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 2002; 288: 2981–97.</mixed-citation><mixed-citation xml:lang="en">The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker versus diuretic: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 2002; 288: 2981–97.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Ruilope LM, Kirwan B-A, de Brouwer S, et al. Uric acid and other renal function parameters in patients with stable angina pectoris participating in the ACTION trial: impact of nifedipine GITS (gastro-intestinal therapeutic system) and relation to outcome. J Hypertensi 2007; 25: 1711–8.</mixed-citation><mixed-citation xml:lang="en">Ruilope LM, Kirwan B-A, de Brouwer S, et al. Uric acid and other renal function parameters in patients with stable angina pectoris participating in the ACTION trial: impact of nifedipine GITS (gastro-intestinal therapeutic system) and relation to outcome. J Hypertensi 2007; 25: 1711–8.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Reyes A J, Leary WP. The increase in serum uric acid induced by diuretics could be beneficial to cardiovascular prognosis in hypertension: a hypothesis. J Hypertens 2003; 21: 1775–7.</mixed-citation><mixed-citation xml:lang="en">Reyes A J, Leary WP. The increase in serum uric acid induced by diuretics could be beneficial to cardiovascular prognosis in hypertension: a hypothesis. J Hypertens 2003; 21: 1775–7.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Кобалава Ж.Д. Клиническое и фармакодинамическое обоснование выбора антигипертензивных препаратов у больных эссенциальной гипертонией с сопутствующими факторами риска. Диссерт доктора мед наук. Москва 1997.</mixed-citation><mixed-citation xml:lang="en">Кобалава Ж.Д. Клиническое и фармакодинамическое обоснование выбора антигипертензивных препаратов у больных эссенциальной гипертонией с сопутствующими факторами риска. Диссерт доктора мед наук. Москва 1997.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Дроздов В.Н. Обмен мочевой кислоты у больных гипертонической болезнью с метаболическим синдромом. Автореф диссерт канд мед наук. Москва 1999.</mixed-citation><mixed-citation xml:lang="en">Дроздов В.Н. Обмен мочевой кислоты у больных гипертонической болезнью с метаболическим синдромом. Автореф диссерт канд мед наук. Москва 1999.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Караулова Ю.Л. Клинико-генетические детерминанты чувствительности/ устойчивости гипертрофии левого желудочка к антигипертензивной терапии. Автореф диссерт канд мед наук. Москва 2001.</mixed-citation><mixed-citation xml:lang="en">Караулова Ю.Л. Клинико-генетические детерминанты чувствительности/ устойчивости гипертрофии левого желудочка к антигипертензивной терапии. Автореф диссерт канд мед наук. Москва 2001.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Iwashima Y, Horio T, Kamide K et al. Uric Acid, Left Ventricular Mass Index, and Risk of Cardiovascular Disease in Essential Hypertension. Hypertension 2006; 47; 195–202.</mixed-citation><mixed-citation xml:lang="en">Iwashima Y, Horio T, Kamide K et al. Uric Acid, Left Ventricular Mass Index, and Risk of Cardiovascular Disease in Essential Hypertension. Hypertension 2006; 47; 195–202.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
