<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-1630</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЭПИДЕМИОЛОГИЯ И ПРОФИЛАКТИКА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>EPIDEMIOLOGY AND PREVENTION</subject></subj-group></article-categories><title-group><article-title>Оценка суммарного коронарного риска у лиц, чья профессия связана со стрессом</article-title><trans-title-group xml:lang="en"><trans-title>Total cardiovascular risk assessment in people with high-stress occupation</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Осипова</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Osipova</surname><given-names>I. V.</given-names></name></name-alternatives><email xlink:type="simple">i.osipova@imex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Антропова</surname><given-names>О. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Antropova</surname><given-names>O. N.</given-names></name></name-alternatives><email xlink:type="simple">i.osipova@imex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Воробьева</surname><given-names>Е. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Vorobyeva</surname><given-names>E. N.</given-names></name></name-alternatives><email xlink:type="simple">i.osipova@imex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Симонова</surname><given-names>Г. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Simonova</surname><given-names>G. I.</given-names></name></name-alternatives><email xlink:type="simple">i.osipova@imex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пырикова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Pyrikova</surname><given-names>N. V.</given-names></name></name-alternatives><email xlink:type="simple">i.osipova@imex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Калинина</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kalinina</surname><given-names>I. V.</given-names></name></name-alternatives><email xlink:type="simple">i.osipova@imex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белоусова</surname><given-names>Т. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Belousova</surname><given-names>T. B.</given-names></name></name-alternatives><email xlink:type="simple">i.osipova@imex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Алтайский государственный медицинский университет</institution></aff><aff xml:lang="en"><institution>Altay State Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>НИИ терапии СО РАМН</institution></aff><aff xml:lang="en"><institution>Therapy Research Institute, Siberian Branch, Russian Academy of Medical Sciences</institution></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>НУЗ ОКБ станции Барнаул</institution></aff><aff xml:lang="en"><institution>Barnaul Station Clinical Hospital</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2008</year></pub-date><pub-date pub-type="epub"><day>20</day><month>12</month><year>2008</year></pub-date><volume>7</volume><issue>6</issue><fpage>33</fpage><lpage>37</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Осипова И.В., Антропова О.Н., Воробьева Е.Н., Симонова Г.И., Пырикова Н.В., Калинина И.В., Белоусова Т.Б., 2008</copyright-statement><copyright-year>2008</copyright-year><copyright-holder xml:lang="ru">Осипова И.В., Антропова О.Н., Воробьева Е.Н., Симонова Г.И., Пырикова Н.В., Калинина И.В., Белоусова Т.Б.</copyright-holder><copyright-holder xml:lang="en">Osipova I.V., Antropova O.N., Vorobyeva E.N., Simonova G.I., Pyrikova N.V., Kalinina I.V., Belousova T.B.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/1630">https://cardiovascular.elpub.ru/jour/article/view/1630</self-uri><abstract><sec><title>Цель</title><p>Цель. Провести сравнительную оценку риска развития фатального сердечно-сосудистого события в ближайшие 10 лет у лиц «стрессовой» профессии и у работающих в условиях низкого профессионального стресса. Проанализировать у лиц «стрессовой» профессии основные факторы, влияющие на прогноз развития сердечно-сосудистых заболеваний (ССЗ) и оценить абсолютный 10-летний риск развития ишемических событий.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Обследованы 449 мужчин с высоким и низким уровнями профессионального стресса в возрасте 22-55 лет. I группу составили работник локомотивных бригад (n=240); средний возраст 42,39±9,06 года; II группу (n=209) - работники с низким профессиональным стрессом (средний возраст 41,1±8,7 года). Методы исследования: выявление факторов риска ССЗ: курение, ранний семейный анамнез ССЗ, систолическое артериальное давление, определение индекса массы тела, гликемии, общего холестерина. Пациентам I группы определяли липидный спектр (ЛС) и С-реактивный белок (СРБ); рассчитывали суммарный 10-летний риск ССЗ, используя шкалу SCORE и абсолютный 10-летний риск развития инфаркта миокарда по модели PROCAM.</p></sec><sec><title>Результаты</title><p>Результаты. У работников «стрессовой» профессии была больше распространена гиперхолестеринемия на 21,4% и высокий суммарный коронарный 10-летний риск на 8,7% (p&lt;0,05). В возрасте 45-55 лет высокий суммарный коронарный риск в 1,6 раза больше у пациентов I группы по сравнению со II. У пациентов I группы наблюдали ухудшение показателей ЛС. По шкале PROCAM пациентов высокого риска было больше (25,0%), по сравнению со шкалой SCORE (15,8%). В группе лиц высокого коронарного риска «стрессовой» профессии СРБ составил 6,7±0,9 мг/л, с умеренным и низким риском - 3,1±0,3 мг/ л. Лица с высоким суммарным риском имели частоту сердечных сокращений (ЧСС) 84,0±4,1 уд/мин, с умеренным и низким риском 75,8±1,6 уд/мин.</p></sec><sec><title>Заключение</title><p>Заключение. Шкала PROCAM является более информативной по сравнению со SCORE для определения суммарного коронарного риска у лиц с высоким психоэмоциональным профессиональным напряжением. В качестве дополнительных факторов сердечно-сосудистого риска у лиц «стрессовых» профессий следует учитывать СРБ и ЧСС.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To compare 10-year fatal cardiovascular event risk in people with high and low-stress occupation. To analyze main determinants of cardiovascular disease (CVD) prognosis and assess 10-year absolute risk of ischemic events in people with high-stress occupation.</p></sec><sec><title>Material and methods</title><p>Material and methods. In total, 449 22-55-year-old men with high and low levels of professional stress were examined. Group I included 240 locomotive brigade workers (mean age 42,39±9,06 years), Group II - 209 workers with low level of professional stress (mean age 41,1±8,7 years). Study methods included CVD risk factor assessment: smoking, CVD in family history, systolic blood pressure, body mass index, glycemia, and total cholesterol  level. In Group I, lipid profile (LP) and C-reactive protein (CRP) level were measured; 10-year total CVD risk was calculated with SCORE scale and 10-year absolute risk of myocardial infarction - by PROCAM scale.</p></sec><sec><title>Results</title><p>Results. In people with high-stress occupation, hypercholesterolemia prevalence was higher by 21,4%, and high 10-year total coronary risk prevalence was higher by 8,7% (p&lt;0,05). In those aged 45-55 years, high total coronary risk was 1,6 times more prevalent in Group I, comparing to Group II. In Group I, LP disturbances were observed. According to PROCAM scale, high coronary risk was more prevalent (25,0%), comparing to SCORE scale assessment (15,8%). Among people with high-stress occupation, CRP level was 6,7±0,9 mg/l in high coronary risk subjects and 3,1±0,3 mg/l in low to moderate risk individuals. Heart rate (HR) was 84,0±4,1 bpm and 75,8±1,6 bpm, respectively.</p></sec><sec><title>Conclusion</title><p>Conclusion. PROCAM scale was more informative than SCORE scale in total coronary risk assessment among people with high professional psycho-emotional stress. CRP and HR should be regarded as additional CVD risk factors in people with high-stress occupation.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>профессиональный стресс</kwd><kwd>факторы риска</kwd><kwd>артериальная гипертония</kwd><kwd>суммарный коронарный 10-летний риск</kwd><kwd>абсолютный 10-летний риск развития инфаркта миокарда</kwd></kwd-group><kwd-group xml:lang="en"><kwd>professional stress</kwd><kwd>risk factors</kwd><kwd>arterial hypertension</kwd><kwd>10-year total coronary risk</kwd><kwd>10-year absolute risk of myocardial infarction</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Европейские рекомендации по профилактике сердечно-сосудистых заболеваний в клинической практике. 2003 г.</mixed-citation><mixed-citation xml:lang="en">Европейские рекомендации по профилактике сердечно-сосудистых заболеваний в клинической практике. 2003 г.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Диагностика и коррекция нарушений липидного обмена с целью профилактики и лечения атеросклероза. Российские рекомендации 3 пересмотр 2007. Приложение 3 к журналу «Кардиоваск тер профил».</mixed-citation><mixed-citation xml:lang="en">Диагностика и коррекция нарушений липидного обмена с целью профилактики и лечения атеросклероза. Российские рекомендации 3 пересмотр 2007. Приложение 3 к журналу «Кардиоваск тер профил».</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Шальнова С.А., Оганов Н.Г., Деев А.Д. Оценка и управление суммарным риском сердечно-сосудистых заболеваний у населения России. Кардиоваск тер профил 2004; 3(4): 4-11.</mixed-citation><mixed-citation xml:lang="en">Шальнова С.А., Оганов Н.Г., Деев А.Д. Оценка и управление суммарным риском сердечно-сосудистых заболеваний у населения России. Кардиоваск тер профил 2004; 3(4): 4-11.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Кобалава Ж.Д.Гудков К.М. Секреты артериальной гипертонии: ответы на ваши вопросы. Москва 2004; 243 с.</mixed-citation><mixed-citation xml:lang="en">Кобалава Ж.Д.Гудков К.М. Секреты артериальной гипертонии: ответы на ваши вопросы. Москва 2004; 243 с.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Bosma H, Marmot MG, Hemingway H, et al. Low job control and risk of coronary heart disease in the Witehall 11 (prospective cohort study). BMJ 1997; 314: 558-65.</mixed-citation><mixed-citation xml:lang="en">Bosma H, Marmot MG, Hemingway H, et al. Low job control and risk of coronary heart disease in the Witehall 11 (prospective cohort study). BMJ 1997; 314: 558-65.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Schnall PL, Schwartz JE, Landsbergis PA. Relation between job strain, alcohol, and ambulatory blood pressure. Hypertension 1992; 19(5): 488-94.</mixed-citation><mixed-citation xml:lang="en">Schnall PL, Schwartz JE, Landsbergis PA. Relation between job strain, alcohol, and ambulatory blood pressure. Hypertension 1992; 19(5): 488-94.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Karasek RA, Theorell T. WHO, Copenhagen. Current issues relating to psychosocial job strain and cardiovascular disease research. J Occupat Hith Psychol 1996; 1: 9-26.</mixed-citation><mixed-citation xml:lang="en">Karasek RA, Theorell T. WHO, Copenhagen. Current issues relating to psychosocial job strain and cardiovascular disease research. J Occupat Hith Psychol 1996; 1: 9-26.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Marmot M, Siegrist I, Theorell T, et al. Health and the psychosocial environment at work. In: Social determinants of health (ed. by Marmot M. and Wilkinson R.G.). Oxford University Press 2000; 105-31.</mixed-citation><mixed-citation xml:lang="en">Marmot M, Siegrist I, Theorell T, et al. Health and the psychosocial environment at work. In: Social determinants of health (ed. by Marmot M. and Wilkinson R.G.). Oxford University Press 2000; 105-31.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Цфасман А.З. Внезапная сердечная смерть (и ее профессиональные аспекты). Москва «МЦНМО» 2003; 302 с.</mixed-citation><mixed-citation xml:lang="en">Цфасман А.З. Внезапная сердечная смерть (и ее профессиональные аспекты). Москва «МЦНМО» 2003; 302 с.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Ginnsberg HN. Hypertriglyceridemia: new insights and new approacyes to treatment. Am J cardiol 2001; 87: 1174-80.</mixed-citation><mixed-citation xml:lang="en">Ginnsberg HN. Hypertriglyceridemia: new insights and new approacyes to treatment. Am J cardiol 2001; 87: 1174-80.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Manninen V, Tenkanen L, Koskinen P, et al. Helsinki Heart Study. Circulation 1992; 85: 37-45.</mixed-citation><mixed-citation xml:lang="en">Manninen V, Tenkanen L, Koskinen P, et al. Helsinki Heart Study. Circulation 1992; 85: 37-45.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Осипова И.В., Зальцман А.Г., Воробьева Е.Н. и др. Распространенность факторов риска и особенности поражения органов-мишеней при стресс-индуцированной артериальной гипертонии у мужчин трудоспособного возраста. Кардиоваск тер профил 2006; 5(2): 10-5.</mixed-citation><mixed-citation xml:lang="en">Осипова И.В., Зальцман А.Г., Воробьева Е.Н. и др. Распространенность факторов риска и особенности поражения органов-мишеней при стресс-индуцированной артериальной гипертонии у мужчин трудоспособного возраста. Кардиоваск тер профил 2006; 5(2): 10-5.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Dyer F, Persky V, Stamler J, et al. Ytart rate as a prognostic fac- tor for coronary heart disease and mortality findings in three Chicago Epidemiological studies. Am J Epidemiol 1980; 112: 736-49.</mixed-citation><mixed-citation xml:lang="en">Dyer F, Persky V, Stamler J, et al. Ytart rate as a prognostic fac- tor for coronary heart disease and mortality findings in three Chicago Epidemiological studies. Am J Epidemiol 1980; 112: 736-49.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Kannel WB, Wilson P, Blair SN. Epidemiological assessment of the role of physical activity and fitness in development of cardio- vascular disease. Am Heart J 1985; 109: 876-85.</mixed-citation><mixed-citation xml:lang="en">Kannel WB, Wilson P, Blair SN. Epidemiological assessment of the role of physical activity and fitness in development of cardio- vascular disease. Am Heart J 1985; 109: 876-85.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Gillmann MW, Kannel WB, Belanger A, et al. Influence of heart rate on mortality among persons with hypertension: the Framingham study. Am Heart J 1993; 125: 1148-54.</mixed-citation><mixed-citation xml:lang="en">Gillmann MW, Kannel WB, Belanger A, et al. Influence of heart rate on mortality among persons with hypertension: the Framingham study. Am Heart J 1993; 125: 1148-54.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Jouven X, Desnos M, Guerot C, et al. Predicting sudden death in the population: the Paris Prospective Study. Circulation 1999; 99: 1978-83.</mixed-citation><mixed-citation xml:lang="en">Jouven X, Desnos M, Guerot C, et al. Predicting sudden death in the population: the Paris Prospective Study. Circulation 1999; 99: 1978-83.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Palatini P, Casiglia E, Julius S, et al. High heart rate: a risk factor for cardiovascular death in elderly men. Arch Int Med 1999; 159: 585-92.</mixed-citation><mixed-citation xml:lang="en">Palatini P, Casiglia E, Julius S, et al. High heart rate: a risk factor for cardiovascular death in elderly men. Arch Int Med 1999; 159: 585-92.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Kristal-Bohen E, Silber H, Harari D, et al. The association of resting heart rate with cardiovascular, cancer and all-cause mortality: eight year follow-up of 3527 male in Israel employees (the CORDIS Study). Eur Heart J 2000; 21: 116-24.</mixed-citation><mixed-citation xml:lang="en">Kristal-Bohen E, Silber H, Harari D, et al. The association of resting heart rate with cardiovascular, cancer and all-cause mortality: eight year follow-up of 3527 male in Israel employees (the CORDIS Study). Eur Heart J 2000; 21: 116-24.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Benetos A, Rudnichi A, Thomas F, et al. Influence of heart rate on mortality in French population: role of age, gender and blood pressure. Hypertension 1999; 33: 44-52.</mixed-citation><mixed-citation xml:lang="en">Benetos A, Rudnichi A, Thomas F, et al. Influence of heart rate on mortality in French population: role of age, gender and blood pressure. Hypertension 1999; 33: 44-52.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
