<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-1638</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Антитромбоцитарные препараты при острых коронарных синдромах и чрескожных коронарных вмешательствах: в фокусе тирофибан</article-title><trans-title-group xml:lang="en"><trans-title>Antiplatelet medications in acute coronary syndromes and percutaneous coronary interventions: focus on tirofiban</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Батыралиев</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Batyraliev</surname><given-names>T. A.</given-names></name></name-alternatives><email xlink:type="simple">talantbekb@yahoo.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Преображенский</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Preobrazhensky</surname><given-names>D. V.</given-names></name></name-alternatives><email xlink:type="simple">talantbekb@yahoo.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фетцер</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Fetzer</surname><given-names>D. V.</given-names></name></name-alternatives><email xlink:type="simple">talantbekb@yahoo.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сидоренко</surname><given-names>Б. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sidorenko</surname><given-names>B. A.</given-names></name></name-alternatives><email xlink:type="simple">talantbekb@yahoo.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Патарая</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Pataraya</surname><given-names>S. A.</given-names></name></name-alternatives><email xlink:type="simple">talantbekb@yahoo.com</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Медицинский центр имени Сани Конукоглы, г. Газиантеп</institution></aff><aff xml:lang="en"><institution>Sani Konukogly Medical Center. Gaziantep</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Учебно-научный медицинский центр Управления делами Президента Российской Федерации, г. Москва</institution></aff><aff xml:lang="en"><institution>Educational and Research Medical Center, RF President Administration. Moscow</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2008</year></pub-date><pub-date pub-type="epub"><day>20</day><month>12</month><year>2008</year></pub-date><volume>7</volume><issue>6</issue><fpage>79</fpage><lpage>88</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Батыралиев Т.А., Преображенский Д.В., Фетцер Д.В., Сидоренко Б.А., Патарая С.А., 2008</copyright-statement><copyright-year>2008</copyright-year><copyright-holder xml:lang="ru">Батыралиев Т.А., Преображенский Д.В., Фетцер Д.В., Сидоренко Б.А., Патарая С.А.</copyright-holder><copyright-holder xml:lang="en">Batyraliev T.A., Preobrazhensky D.V., Fetzer D.V., Sidorenko B.A., Pataraya S.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/1638">https://cardiovascular.elpub.ru/jour/article/view/1638</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>острый коронарный синдром</kwd><kwd>чрескожное коронарное вмешательство</kwd><kwd>ингибиторы IIb/IIIa рецепторов тромбоцитов</kwd><kwd>тирофибан</kwd><kwd>абциксимаб</kwd><kwd>эптифибатид</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acute coronary syndrome</kwd><kwd>percutaneous coronary intervention</kwd><kwd>platelet IIb/IIIa receptor inhibitors</kwd><kwd>tirofiban</kwd><kwd>abciximab</kwd><kwd>eptifibatide</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Fuster V., Badimon L., Badimon J.J., Chesebro J.H. The pathogenesis of coronary artery disease and the acute coronary syndromes (1). N. Engl. J. Med. 1992; 326: 242-50.</mixed-citation><mixed-citation xml:lang="en">Fuster V., Badimon L., Badimon J.J., Chesebro J.H. The pathogenesis of coronary artery disease and the acute coronary syndromes (1). N. Engl. J. Med. 1992; 326: 242-50.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Fuster V., Badimon L., Badimon J.J., Chesebro J.H. The pathogenesis of coronary artery disease and the acute coronary syndromes (2). N. Engl. J. Med. 1992; 326: 310-8.</mixed-citation><mixed-citation xml:lang="en">Fuster V., Badimon L., Badimon J.J., Chesebro J.H. The pathogenesis of coronary artery disease and the acute coronary syndromes (2). N. Engl. J. Med. 1992; 326: 310-8.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">White H. Unstable angina: Ischemic syndromes. In: Textbook of cardiovascular medicine. Topol E. (ed.). 3d edition. Philadelphia 2007; 251-79.</mixed-citation><mixed-citation xml:lang="en">White H. Unstable angina: Ischemic syndromes. In: Textbook of cardiovascular medicine. Topol E. (ed.). 3d edition. Philadelphia 2007; 251-79.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Topol E., van de Werf F.J. Acute myocardial infarction -In: Textbook of cardiovascular medicine. Topol E. (ed.). 3d edition. Philadelphia 2007; 280-302.</mixed-citation><mixed-citation xml:lang="en">Topol E., van de Werf F.J. Acute myocardial infarction -In: Textbook of cardiovascular medicine. Topol E. (ed.). 3d edition. Philadelphia 2007; 280-302.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Cohen M. Treatment of unstable angina: The role of platelet inhibitors and anticoagulants. J. Invasive Cardiology 1999; 11: 147-59.</mixed-citation><mixed-citation xml:lang="en">Cohen M. Treatment of unstable angina: The role of platelet inhibitors and anticoagulants. J. Invasive Cardiology 1999; 11: 147-59.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Meier B. Percutaneous coronary intervention. -In: Textbook of cardiovascular medicine. Topol E. (ed.). 3d edition. Philadelphia 2007; 1258-89.</mixed-citation><mixed-citation xml:lang="en">Meier B. Percutaneous coronary intervention. -In: Textbook of cardiovascular medicine. Topol E. (ed.). 3d edition. Philadelphia 2007; 1258-89.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Becker R.C., Fintel D.J., Green D. Antithrombotic therapy. 4th edition. New York 2006.</mixed-citation><mixed-citation xml:lang="en">Becker R.C., Fintel D.J., Green D. Antithrombotic therapy. 4th edition. New York 2006.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Shimbo D., Pickering Th. Platelet in cardiovascular and noncardiovascular disorders: pathophysiology, pharmacology, and therapeutics. Cardiovascular Reviews &amp; Reports 2004; 25: 18-24.</mixed-citation><mixed-citation xml:lang="en">Shimbo D., Pickering Th. Platelet in cardiovascular and noncardiovascular disorders: pathophysiology, pharmacology, and therapeutics. Cardiovascular Reviews &amp; Reports 2004; 25: 18-24.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Б.А. Сидоренко, Д.В. Преображенский. Клиническое применение антитромботических препаратов. Москва 1998.</mixed-citation><mixed-citation xml:lang="en">Б.А. Сидоренко, Д.В. Преображенский. Клиническое применение антитромботических препаратов. Москва 1998.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Bhatt D.L., Topol E.J. Scientific and therapeutic advances in anti-platelet therapy. Nature Reviews 2003; 2: 15-28.</mixed-citation><mixed-citation xml:lang="en">Bhatt D.L., Topol E.J. Scientific and therapeutic advances in anti-platelet therapy. Nature Reviews 2003; 2: 15-28.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Messmore Jr.H.L., Wehrmacher W.H., Cayne E., Jeske W. The clinical utility of antiplatelet drugs revised. Cardiovascular Reviews &amp; Reports 2004; 25: 29-32.</mixed-citation><mixed-citation xml:lang="en">Messmore Jr.H.L., Wehrmacher W.H., Cayne E., Jeske W. The clinical utility of antiplatelet drugs revised. Cardiovascular Reviews &amp; Reports 2004; 25: 29-32.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Topol E.J., Byzova T.V., Plow E.F. Platelet GP IIb/IIIa blockers. Lancet 1999; 353: 227-31.</mixed-citation><mixed-citation xml:lang="en">Topol E.J., Byzova T.V., Plow E.F. Platelet GP IIb/IIIa blockers. Lancet 1999; 353: 227-31.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17187 cases of suspected acute myocardial infarction. Lancet 1988; 2: 349-60.</mixed-citation><mixed-citation xml:lang="en">ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17187 cases of suspected acute myocardial infarction. Lancet 1988; 2: 349-60.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Konig D.F., Hasselblad V., Kandzari D.E., et al. Seeking the optimal aspirin dose in acute coronary syndromes. Am. J. Cardiol. 2002; 90: 622-5.</mixed-citation><mixed-citation xml:lang="en">Konig D.F., Hasselblad V., Kandzari D.E., et al. Seeking the optimal aspirin dose in acute coronary syndromes. Am. J. Cardiol. 2002; 90: 622-5.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Yusuf S., Zhao F., Merita S.R., et al. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. New Engl. J. Med. 2001; 345: 494-502.</mixed-citation><mixed-citation xml:lang="en">Yusuf S., Zhao F., Merita S.R., et al. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. New Engl. J. Med. 2001; 345: 494-502.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Mehta S.R., Yusuf S., Peters R.J., et al. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention; the PCI-CURE study. Lancet 2001; 358: 527-33.</mixed-citation><mixed-citation xml:lang="en">Mehta S.R., Yusuf S., Peters R.J., et al. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention; the PCI-CURE study. Lancet 2001; 358: 527-33.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Steinhubl S.R., Berger P.B., Mann J.T. III, et al. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention. JACC 2002; 288: 2411-20.</mixed-citation><mixed-citation xml:lang="en">Steinhubl S.R., Berger P.B., Mann J.T. III, et al. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention. JACC 2002; 288: 2411-20.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">The GUSTO-IV ACS investigators. Effect of glycoprotein IIb/ IIIa receptor blocker abciximab on outcome in patients with acute coronary syndromes without early coronary revasculariza- tion: the GUSTO-IV ACS. Lancet 2001; 357: 1915–24.</mixed-citation><mixed-citation xml:lang="en">The GUSTO-IV ACS investigators. Effect of glycoprotein IIb/ IIIa receptor blocker abciximab on outcome in patients with acute coronary syndromes without early coronary revasculariza- tion: the GUSTO-IV ACS. Lancet 2001; 357: 1915–24.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Cook JJ, Bednar B, Lynch JJ, et al. Tirofiban (Aggrastat). Cardiovascular Drug Reviews 1999; 17: 199–224.</mixed-citation><mixed-citation xml:lang="en">Cook JJ, Bednar B, Lynch JJ, et al. Tirofiban (Aggrastat). Cardiovascular Drug Reviews 1999; 17: 199–224.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">The RESTORE investigators. Effects of platelet glycoprotein IIb/IIIa blockade with tirofiban on adverse cardiac events in unstable angina or myocardial infarction undergoing coronary angioplasty. Circulation 1997; 96: 1445–53.</mixed-citation><mixed-citation xml:lang="en">The RESTORE investigators. Effects of platelet glycoprotein IIb/IIIa blockade with tirofiban on adverse cardiac events in unstable angina or myocardial infarction undergoing coronary angioplasty. Circulation 1997; 96: 1445–53.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">The RESTORE investigators. Six month angiographic and clinical follow-up of patients prospectively randomized to either tirofiban or placebo during in the RESTORE. JACC 1998; 32: 28–34.</mixed-citation><mixed-citation xml:lang="en">The RESTORE investigators. Six month angiographic and clinical follow-up of patients prospectively randomized to either tirofiban or placebo during in the RESTORE. JACC 1998; 32: 28–34.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Valgimigli M, Percoco G, Barbieri D, et al. The additive value of tirofiban administrated with high-dose bolus in the prevention of ischemic complications during high-risk coronary angioplasty. JACC 2004; 44: 14–9.</mixed-citation><mixed-citation xml:lang="en">Valgimigli M, Percoco G, Barbieri D, et al. The additive value of tirofiban administrated with high-dose bolus in the prevention of ischemic complications during high-risk coronary angioplasty. JACC 2004; 44: 14–9.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">The Platelet Receptor Inhibition in Ischemic Syndrome Management (PRISM) study investigators. A comparison of aspirin plus tirofiban with aspirin plus heparin for unstable angina. New Engl J Med 1998; 338: 1498–505.</mixed-citation><mixed-citation xml:lang="en">The Platelet Receptor Inhibition in Ischemic Syndrome Management (PRISM) study investigators. A comparison of aspirin plus tirofiban with aspirin plus heparin for unstable angina. New Engl J Med 1998; 338: 1498–505.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">The Platelet Receptor Inhibition in Ischemic Syndrome Management in Patients Limited by Unstable Signs and symp- toms (PRISMPLUS) study investigators. Inhibition of the platelet glycoprotein IIb/IIIa receptor with tirofiban in unstable angina and nonQwave myocardial infarction. N Engl J Med 1998; 338: 1488–97.</mixed-citation><mixed-citation xml:lang="en">The Platelet Receptor Inhibition in Ischemic Syndrome Management in Patients Limited by Unstable Signs and symp- toms (PRISMPLUS) study investigators. Inhibition of the platelet glycoprotein IIb/IIIa receptor with tirofiban in unstable angina and nonQwave myocardial infarction. N Engl J Med 1998; 338: 1488–97.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Morrow D, Antman EM, Snapinn SM, et al. An integrated clinical approach to predicting the benefit of tirofiban in non-ST-segment elevation acute coronary syndromes: Application of the TIMI risk score for UA/NSTEMI in PRISM-PLUS. Eur Heart J 2002; 23: 223–9.</mixed-citation><mixed-citation xml:lang="en">Morrow D, Antman EM, Snapinn SM, et al. An integrated clinical approach to predicting the benefit of tirofiban in non-ST-segment elevation acute coronary syndromes: Application of the TIMI risk score for UA/NSTEMI in PRISM-PLUS. Eur Heart J 2002; 23: 223–9.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Morrow D, Sabatine M, Cannon C, et al. Benefit of tirofiban among patients treated without coronary intervention: Application of the TIMI risk score for unstable angina and non-ST-segment elevation myocardial infarction in PRISM-PLUS. Circulation 2002; 104 (Suppl. II): 782 (abstract).</mixed-citation><mixed-citation xml:lang="en">Morrow D, Sabatine M, Cannon C, et al. Benefit of tirofiban among patients treated without coronary intervention: Application of the TIMI risk score for unstable angina and non-ST-segment elevation myocardial infarction in PRISM-PLUS. Circulation 2002; 104 (Suppl. II): 782 (abstract).</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Martinez-Rios MA, Rosas M, Gonzalez H, et al. Comparison of reperfusion regimens with or without tirofiban in ST-elevation acute myocardial infarction. Am J Cardiol 2004; 93: 280–7.</mixed-citation><mixed-citation xml:lang="en">Martinez-Rios MA, Rosas M, Gonzalez H, et al. Comparison of reperfusion regimens with or without tirofiban in ST-elevation acute myocardial infarction. Am J Cardiol 2004; 93: 280–7.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Roffi M, Topol E. Percutaneous coronary intervention in diabetic patients with non-ST-segment elevation acute coronary syndromes. Eur Heart J 2004; 25: 190–8.</mixed-citation><mixed-citation xml:lang="en">Roffi M, Topol E. Percutaneous coronary intervention in diabetic patients with non-ST-segment elevation acute coronary syndromes. Eur Heart J 2004; 25: 190–8.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Roffi M, Chew DP, Makherjee D, et al. Platelet glycopro- tein IIb/IIIa inhibitors reduce mortality in diabetic patients with non-ST-segment-elevation acute coronary syndromes. Circulation 2001; 104: 2767–71.</mixed-citation><mixed-citation xml:lang="en">Roffi M, Chew DP, Makherjee D, et al. Platelet glycopro- tein IIb/IIIa inhibitors reduce mortality in diabetic patients with non-ST-segment-elevation acute coronary syndromes. Circulation 2001; 104: 2767–71.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Boersma E, Harrington RA, Moliterno DJ, et al. Platelet gly- coprotein IIb/IIIa inhibitors in acute coronary syndromes: a meta-analysis of all major randomised trials. Lancet 2002; 359: 189–98.</mixed-citation><mixed-citation xml:lang="en">Boersma E, Harrington RA, Moliterno DJ, et al. Platelet gly- coprotein IIb/IIIa inhibitors in acute coronary syndromes: a meta-analysis of all major randomised trials. Lancet 2002; 359: 189–98.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Chew DP, Moliterno DJ. A critical appraisal of platelet glycopro- tein IIb/IIIa inhibition. JACC 2000; 36: 2028–35.</mixed-citation><mixed-citation xml:lang="en">Chew DP, Moliterno DJ. A critical appraisal of platelet glycopro- tein IIb/IIIa inhibition. JACC 2000; 36: 2028–35.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Topol E, Moliterno D, Herrmann H, et al. Comparison of two platelet glycoprotein IIb/IIIa inhibitors, tirofiban and abciximab, for the prevention of ischemic events with percu- taneous coronary revascularization. N Engl J Med 2001; 344: 1888–94.</mixed-citation><mixed-citation xml:lang="en">Topol E, Moliterno D, Herrmann H, et al. Comparison of two platelet glycoprotein IIb/IIIa inhibitors, tirofiban and abciximab, for the prevention of ischemic events with percu- taneous coronary revascularization. N Engl J Med 2001; 344: 1888–94.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Kandzari DE, Califf RM. TARGET versus GUSTO-IV: appro- priate use of glycoprotein IIb/IIIa inhibitors in acute coronary syndromes and percutaneous coronary intervention. Current Opin Cardiol 2002; 17: 332–9.</mixed-citation><mixed-citation xml:lang="en">Kandzari DE, Califf RM. TARGET versus GUSTO-IV: appro- priate use of glycoprotein IIb/IIIa inhibitors in acute coronary syndromes and percutaneous coronary intervention. Current Opin Cardiol 2002; 17: 332–9.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Chew DP, Moliterno DJ. A critical appraisal of platelet glycopro- tein IIb/IIIa inhibition. JACC 2000; 36: 2028–35.</mixed-citation><mixed-citation xml:lang="en">Chew DP, Moliterno DJ. A critical appraisal of platelet glycopro- tein IIb/IIIa inhibition. JACC 2000; 36: 2028–35.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Steinhubl SR, Talley JD, Braden GA, et al. Pointof care measured platelet inhibition correlates with a rediced risk of an adverse cardiac event after percutaneous coronary revasculariza- tion. Results of the GOLD (AU-Assessing Ultegra) multicenter study. Circulation 2001; 103: 2572–8.</mixed-citation><mixed-citation xml:lang="en">Steinhubl SR, Talley JD, Braden GA, et al. Pointof care measured platelet inhibition correlates with a rediced risk of an adverse cardiac event after percutaneous coronary revasculariza- tion. Results of the GOLD (AU-Assessing Ultegra) multicenter study. Circulation 2001; 103: 2572–8.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
