<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-1641</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Плейотропная активность антигипертензивных препаратов в атеротромбогенезе. Небиволол: расширение возможностей и снижение ограничений</article-title><trans-title-group xml:lang="en"><trans-title>Pleiotropic activity of antihypertensives in atherothrombogenesis. Nebivolol: increasing possibilities and reducing restrictions</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бубнова</surname><given-names>М. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Bubnova</surname><given-names>M. G.</given-names></name></name-alternatives><email xlink:type="simple">mbubnova@gnicpm.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГУ Государственный научно-исследовательский центр профилактической медицины, г. Москва</institution></aff><aff xml:lang="en"><institution>State Research Center for Preventive Medicine. Moscow</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2008</year></pub-date><pub-date pub-type="epub"><day>20</day><month>12</month><year>2008</year></pub-date><volume>7</volume><issue>6</issue><fpage>94</fpage><lpage>104</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бубнова М.Г., 2008</copyright-statement><copyright-year>2008</copyright-year><copyright-holder xml:lang="ru">Бубнова М.Г.</copyright-holder><copyright-holder xml:lang="en">Bubnova M.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/1641">https://cardiovascular.elpub.ru/jour/article/view/1641</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>артериальная гипертония</kwd><kwd>β-адреноблокаторы</kwd><kwd>плейотропные эффекты</kwd><kwd>атеротромбогенез</kwd><kwd>небиволол</kwd></kwd-group><kwd-group xml:lang="en"><kwd>arterial hypertension</kwd><kwd>beta-adrenoblockers</kwd><kwd>pleiotropic effects</kwd><kwd>atherothrombogenesis</kwd><kwd>nebivolol</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Mancia G, Backer G, Dominiczak A, et al. 2007 Guidelines for the Management of Arterial Hypertension. The Task Force for the of the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2007; 26: 1105–87.</mixed-citation><mixed-citation xml:lang="en">Mancia G, Backer G, Dominiczak A, et al. 2007 Guidelines for the Management of Arterial Hypertension. The Task Force for the of the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2007; 26: 1105–87.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Sharma AM, Pischon T, Hardt S, et al. Hypothesis: Beta-adrenergic receptor blockers and weight gain: a systematic analysis. J Hypertens 2001; 37: 250–4.</mixed-citation><mixed-citation xml:lang="en">Sharma AM, Pischon T, Hardt S, et al. Hypothesis: Beta-adrenergic receptor blockers and weight gain: a systematic analysis. J Hypertens 2001; 37: 250–4.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Mancia G, Grassi G, Zanchetti A. New-onset diabetes and antihypertensive drugs. J Hypertens 2006; 24: 3–10.</mixed-citation><mixed-citation xml:lang="en">Mancia G, Grassi G, Zanchetti A. New-onset diabetes and antihypertensive drugs. J Hypertens 2006; 24: 3–10.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Opie LH, Schall R. Old antihypertensives and diabetes. J Hypertens 2004; 22: 1453–8.</mixed-citation><mixed-citation xml:lang="en">Opie LH, Schall R. Old antihypertensives and diabetes. J Hypertens 2004; 22: 1453–8.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Carlberg B, Samuelsson O, Lindholm LH, Atenolol in hypertension: is it a wise chouse? Lancet 2004; 364: 1684–9.</mixed-citation><mixed-citation xml:lang="en">Carlberg B, Samuelsson O, Lindholm LH, Atenolol in hypertension: is it a wise chouse? Lancet 2004; 364: 1684–9.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Lindholm LH, Carlberg B, Samuelsson O. Should beta blockers remain first choice in the treatment of primary hypertension? A meta-analysis. Lancet 2005; 366: 1545–53.</mixed-citation><mixed-citation xml:lang="en">Lindholm LH, Carlberg B, Samuelsson O. Should beta blockers remain first choice in the treatment of primary hypertension? A meta-analysis. Lancet 2005; 366: 1545–53.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Dahlцf B, Sever P, Poulter N, et al. Prevention of coronary and store events with antihypertension regimen of amlodip- ine adding perindopril as required versus atenolol adding bendroflumethiazide as required in the Ango-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOTT- LLA): a multicentre randomized controlled trial. Lancet 2005; 366: 895–906.</mixed-citation><mixed-citation xml:lang="en">Dahlцf B, Sever P, Poulter N, et al. Prevention of coronary and store events with antihypertension regimen of amlodip- ine adding perindopril as required versus atenolol adding bendroflumethiazide as required in the Ango-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOTT- LLA): a multicentre randomized controlled trial. Lancet 2005; 366: 895–906.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">New BHS-NICE guidelines (June 2006). Prescription guidelines in cardiology. Editions Frison-Roche 2006.</mixed-citation><mixed-citation xml:lang="en">New BHS-NICE guidelines (June 2006). Prescription guidelines in cardiology. Editions Frison-Roche 2006.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Zanchetti A. Clinical pharmacodymamics of nebivolol: new evidence of nitric oxide-mediated vasodilatating activity and peculiar hemodynamic properties in hypertensive patients. Blood Pressure 2004; 13(Suppl 1): 17–32.</mixed-citation><mixed-citation xml:lang="en">Zanchetti A. Clinical pharmacodymamics of nebivolol: new evidence of nitric oxide-mediated vasodilatating activity and peculiar hemodynamic properties in hypertensive patients. Blood Pressure 2004; 13(Suppl 1): 17–32.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Yusuf S, Peto R, Lewis J, et al. Beta-blockade during and after myocardial infarction: an overview of the randomized trials. Prog Cardiovasc Dis 1985; XVII (5): 335–71.</mixed-citation><mixed-citation xml:lang="en">Yusuf S, Peto R, Lewis J, et al. Beta-blockade during and after myocardial infarction: an overview of the randomized trials. Prog Cardiovasc Dis 1985; XVII (5): 335–71.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Kamp O, Sieswerda GT, Visser CA. Favorable effects on systolic and diastolic left ventricular function of nebivolol in comparison to atenolol in patients with uncomplicated essential hypertension. Am J Cardiol 2003; 92: 344–8.</mixed-citation><mixed-citation xml:lang="en">Kamp O, Sieswerda GT, Visser CA. Favorable effects on systolic and diastolic left ventricular function of nebivolol in comparison to atenolol in patients with uncomplicated essential hypertension. Am J Cardiol 2003; 92: 344–8.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Nodari S, Metra M, Dei Cas L. Beta-blocker treatment of the patients with diastolic heart failure and arterial hypertension. A prospective randomized comparison of the long0term effects of atenolol versus nebivolol. Eur J Heart Fail 2003; 5: 621–7.</mixed-citation><mixed-citation xml:lang="en">Nodari S, Metra M, Dei Cas L. Beta-blocker treatment of the patients with diastolic heart failure and arterial hypertension. A prospective randomized comparison of the long0term effects of atenolol versus nebivolol. Eur J Heart Fail 2003; 5: 621–7.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Flather MD, Shibata MC, Coats AJ, et al. Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS). Eur Heart J 2005; 26: 215–25.</mixed-citation><mixed-citation xml:lang="en">Flather MD, Shibata MC, Coats AJ, et al. Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS). Eur Heart J 2005; 26: 215–25.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Edes I, Gasior Z, Wita K. Effect of nebivolol on left ventricular function in elderly patients with chronic heart failure: results of the ENECA study. Eur J Heart Fail 2005; 7: 631–9.</mixed-citation><mixed-citation xml:lang="en">Edes I, Gasior Z, Wita K. Effect of nebivolol on left ventricular function in elderly patients with chronic heart failure: results of the ENECA study. Eur J Heart Fail 2005; 7: 631–9.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Taddei S, Virdis A, Chiadoni L, Salvetti A The pivotal role of endothelium in hypertension. Medicographia 1999; Issue 59; 21: 22–9.</mixed-citation><mixed-citation xml:lang="en">Taddei S, Virdis A, Chiadoni L, Salvetti A The pivotal role of endothelium in hypertension. Medicographia 1999; Issue 59; 21: 22–9.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Lusher TF, Barton M. Biology of the endothelium. Clin Cardiol 1997; 20(Suppl II): II-3–10.</mixed-citation><mixed-citation xml:lang="en">Lusher TF, Barton M. Biology of the endothelium. Clin Cardiol 1997; 20(Suppl II): II-3–10.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Gardiner SM, Compton AM, Bennet T, et al. Control of regional blood flow by endothelium-derived nitric oxide. J Hypertens 1990; 15: 486–92.</mixed-citation><mixed-citation xml:lang="en">Gardiner SM, Compton AM, Bennet T, et al. Control of regional blood flow by endothelium-derived nitric oxide. J Hypertens 1990; 15: 486–92.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Задионченко В.С., Адашева Т.В., Сандамирская А.П., Суворова С.С. Дисфункция эндотелия, артериальная гипертония: терапевтические возможности. Кардиоваск тер про- фил 2003; 2: 79–90.</mixed-citation><mixed-citation xml:lang="en">Задионченко В.С., Адашева Т.В., Сандамирская А.П., Суворова С.С. Дисфункция эндотелия, артериальная гипертония: терапевтические возможности. Кардиоваск тер про- фил 2003; 2: 79–90.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Tsao PS, Wang B, Buitrago R, et al. Nitric oxide regulates monocyte chemotactic protein-1. Circulation 1997; 6: 934–40.</mixed-citation><mixed-citation xml:lang="en">Tsao PS, Wang B, Buitrago R, et al. Nitric oxide regulates monocyte chemotactic protein-1. Circulation 1997; 6: 934–40.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Schдchinger V, Britten MB, Zeiher AM. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 2000; 101: 1899–906.</mixed-citation><mixed-citation xml:lang="en">Schдchinger V, Britten MB, Zeiher AM. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 2000; 101: 1899–906.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Maffei H, Vecchione C, Aretini A, et al. Characterization of nitric oxide release by nebivolol and its metabolites. Am J Hypertens 2006; 19: 579–86.</mixed-citation><mixed-citation xml:lang="en">Maffei H, Vecchione C, Aretini A, et al. Characterization of nitric oxide release by nebivolol and its metabolites. Am J Hypertens 2006; 19: 579–86.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Dessy C, Saliez J, Ghisdal P, et al. Endothelial beta-3- adrenoreceptors mediate nitric oxide-dependent vasorelaxation of coronary microvessels in response to the third-generation beta- blocker nebivolol. Circulation 2005; 112: 1198–205.</mixed-citation><mixed-citation xml:lang="en">Dessy C, Saliez J, Ghisdal P, et al. Endothelial beta-3- adrenoreceptors mediate nitric oxide-dependent vasorelaxation of coronary microvessels in response to the third-generation beta- blocker nebivolol. Circulation 2005; 112: 1198–205.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Garban HJ, Buga GM, Ignarro LJ. Estrogen-receptor mediated vascular responsiveness to nebivolol: a novel endothelium-related mechanism of therapeutic vasorelaxation. J Cardiovasc Pharmacol 2004; 43: 638–44.</mixed-citation><mixed-citation xml:lang="en">Garban HJ, Buga GM, Ignarro LJ. Estrogen-receptor mediated vascular responsiveness to nebivolol: a novel endothelium-related mechanism of therapeutic vasorelaxation. J Cardiovasc Pharmacol 2004; 43: 638–44.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Rosei EA, Rizzoni D. Metabolic profile of nebivolol, a β-adrenoceptor antagonist with unique characteristics. Drug 2007; 67: 1097–107.</mixed-citation><mixed-citation xml:lang="en">Rosei EA, Rizzoni D. Metabolic profile of nebivolol, a β-adrenoceptor antagonist with unique characteristics. Drug 2007; 67: 1097–107.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Gosgnach W, Boixel C, Nevo N, et al. Nebivolol induce calcium- independent signaling in endothelial cells by a possible β-adrenergic pathway. J Cardiovasc Pharmacol 2001; 38: 191–9.</mixed-citation><mixed-citation xml:lang="en">Gosgnach W, Boixel C, Nevo N, et al. Nebivolol induce calcium- independent signaling in endothelial cells by a possible β-adrenergic pathway. J Cardiovasc Pharmacol 2001; 38: 191–9.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Kalinowski L, Dobrucki LW, Szczepanska-Konkel M, et al. Third- generation β-blocker stimulation nitric oxide release from endothelial cells through ATP efflux. Circulation 2003; 107: 2747–52.</mixed-citation><mixed-citation xml:lang="en">Kalinowski L, Dobrucki LW, Szczepanska-Konkel M, et al. Third- generation β-blocker stimulation nitric oxide release from endothelial cells through ATP efflux. Circulation 2003; 107: 2747–52.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Rizos E, Bairaktari E, Kostoula A, et al. The combination of nebivolol plus pravastatin is associated with a more beneficial metabolic profile compared to that of atenolol plus pravastatin in hypertension patients with dyslipidemia: a pilot study. J Cardiovasc Pharmacol Ther 2003; 8: 127–34.</mixed-citation><mixed-citation xml:lang="en">Rizos E, Bairaktari E, Kostoula A, et al. The combination of nebivolol plus pravastatin is associated with a more beneficial metabolic profile compared to that of atenolol plus pravastatin in hypertension patients with dyslipidemia: a pilot study. J Cardiovasc Pharmacol Ther 2003; 8: 127–34.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Cirillo P, Golino P, Calabro P, et al. C-rtactive protein induces tissue factor expression and promotes smooth muscle and endothelial cell proliferation. Cardiovasc Res 2005; 68: 47–55.</mixed-citation><mixed-citation xml:lang="en">Cirillo P, Golino P, Calabro P, et al. C-rtactive protein induces tissue factor expression and promotes smooth muscle and endothelial cell proliferation. Cardiovasc Res 2005; 68: 47–55.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Celik T, Iyisoy A, Kursaklioglu H, et al. Comparative effects of nebivolol and metoprolol on oxidative stress, insulin resistance, plasma adiponectine and soluble P-selectin levels in hypertensive patients. J Hypertens 2006; 24: 591–6.</mixed-citation><mixed-citation xml:lang="en">Celik T, Iyisoy A, Kursaklioglu H, et al. Comparative effects of nebivolol and metoprolol on oxidative stress, insulin resistance, plasma adiponectine and soluble P-selectin levels in hypertensive patients. J Hypertens 2006; 24: 591–6.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Harrison DG, Ohara Y. Physiologic consequences of increased vascular oxidant stresses in hypercholesterolemia and atherosclerosis: implica- tions for impaired vasomotion. Am J Cardiol 1995; 75: 75B-81.</mixed-citation><mixed-citation xml:lang="en">Harrison DG, Ohara Y. Physiologic consequences of increased vascular oxidant stresses in hypercholesterolemia and atherosclerosis: implica- tions for impaired vasomotion. Am J Cardiol 1995; 75: 75B-81.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Cominacini L, Fratta Pasini A, Garbin U, et al. Nebivolol and its 4- keto derivative increase nitric oxide in endothelial cells by reducing its oxidative inactivation. JACC 2003; 42: 1838–44.</mixed-citation><mixed-citation xml:lang="en">Cominacini L, Fratta Pasini A, Garbin U, et al. Nebivolol and its 4- keto derivative increase nitric oxide in endothelial cells by reducing its oxidative inactivation. JACC 2003; 42: 1838–44.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Troost R, Schwedhelm E, Rojczyk S, et al. Nebivolol decrease systemic oxidative stress in healthy volunteers. Br J Clin Pharmacol 2000; 50: 377–9.</mixed-citation><mixed-citation xml:lang="en">Troost R, Schwedhelm E, Rojczyk S, et al. Nebivolol decrease systemic oxidative stress in healthy volunteers. Br J Clin Pharmacol 2000; 50: 377–9.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Fratta Passini A, Garbin U, Nava MC, et al. Nebivolol decrease oxidative stress in essential hypertensive patients and increases nitric oxide by reducing its oxidative inactivation. J Hypertens 2005; 23: 589–96.</mixed-citation><mixed-citation xml:lang="en">Fratta Passini A, Garbin U, Nava MC, et al. Nebivolol decrease oxidative stress in essential hypertensive patients and increases nitric oxide by reducing its oxidative inactivation. J Hypertens 2005; 23: 589–96.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Wolf SC, Sauter G, Preyer M, et al. Influence of nebivolol and metoprolol on inflammatory mediators in human coronary endothelial or smooth muscle cells. Effects on neointima formation after balloon denudation in carotid arteries of rats treated with nebivolol. Cell Physiol Biochem 2007; 19: 129–36.</mixed-citation><mixed-citation xml:lang="en">Wolf SC, Sauter G, Preyer M, et al. Influence of nebivolol and metoprolol on inflammatory mediators in human coronary endothelial or smooth muscle cells. Effects on neointima formation after balloon denudation in carotid arteries of rats treated with nebivolol. Cell Physiol Biochem 2007; 19: 129–36.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Pesant Y, Marc-Aurele J, Bielman P, et al. Metabolic and antihypertension effects of nebivolol and atenolol in normometabolic patients with mild-moderate hypertension. Am J Therap 1999; 6: 137–47.</mixed-citation><mixed-citation xml:lang="en">Pesant Y, Marc-Aurele J, Bielman P, et al. Metabolic and antihypertension effects of nebivolol and atenolol in normometabolic patients with mild-moderate hypertension. Am J Therap 1999; 6: 137–47.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Gryglewski RJ, Uracz W, Marcinkiewicz E, et al. Role of endothelial nitric oxide in pleiotropic action of cardiovascular drug: nebivolol. In Gryglewski RJ and Minuz P, editors. Nitric oxide: basis research and clinical applications. Amsterdam: IOS Press, 2001: 57–69.</mixed-citation><mixed-citation xml:lang="en">Gryglewski RJ, Uracz W, Marcinkiewicz E, et al. Role of endothelial nitric oxide in pleiotropic action of cardiovascular drug: nebivolol. In Gryglewski RJ and Minuz P, editors. Nitric oxide: basis research and clinical applications. Amsterdam: IOS Press, 2001: 57–69.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Falciani M, Rinaldi B, D`Agostino B, et al. Effects of nebivolol on human platelet aggregation. J Cardiovasc Pharmacol 2001; 38: 922–9.</mixed-citation><mixed-citation xml:lang="en">Falciani M, Rinaldi B, D`Agostino B, et al. Effects of nebivolol on human platelet aggregation. J Cardiovasc Pharmacol 2001; 38: 922–9.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Rabkin SW. Mechanisms of action of abrenergin receptor blockers on lipid during antihypertensive drug treatment. J Clin Pharmacol 1993; 33: 286–91.</mixed-citation><mixed-citation xml:lang="en">Rabkin SW. Mechanisms of action of abrenergin receptor blockers on lipid during antihypertensive drug treatment. J Clin Pharmacol 1993; 33: 286–91.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Von Fallois J, Faulhaber HD. Nebivolol, a beta-blocker of 3rd generation: modern therapy of arterial hypertension. Results of a multicenter observation study. Schweiz Rundsch Med Prax 2001; 90: 435–41.</mixed-citation><mixed-citation xml:lang="en">Von Fallois J, Faulhaber HD. Nebivolol, a beta-blocker of 3rd generation: modern therapy of arterial hypertension. Results of a multicenter observation study. Schweiz Rundsch Med Prax 2001; 90: 435–41.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Christlieb R, Mmaki P. The effect beta-blocker therapy on glucose, lipid metabolism. Primary Cardiol 1980; 1(Suppl): 47–54.</mixed-citation><mixed-citation xml:lang="en">Christlieb R, Mmaki P. The effect beta-blocker therapy on glucose, lipid metabolism. Primary Cardiol 1980; 1(Suppl): 47–54.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Маколкин В.И., Ахмедова О.О., Бувальцев В.И. и др. Клинические и метаболические эффекты кардиоселективных β-блокаторов небиволола и метопролола у больных артериальной гипертонией и ишемической болезнью сердца в сочетании с сахарным диабетом 2-го типа. Кардиология 2003; 2: 40–3.</mixed-citation><mixed-citation xml:lang="en">Маколкин В.И., Ахмедова О.О., Бувальцев В.И. и др. Клинические и метаболические эффекты кардиоселективных β-блокаторов небиволола и метопролола у больных артериальной гипертонией и ишемической болезнью сердца в сочетании с сахарным диабетом 2-го типа. Кардиология 2003; 2: 40–3.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">DeFronzo RA, Ferrannini E. Insulin resistance: a multi-faceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia. Diabetes Care 1991; 14: 173–7.</mixed-citation><mixed-citation xml:lang="en">DeFronzo RA, Ferrannini E. Insulin resistance: a multi-faceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia. Diabetes Care 1991; 14: 173–7.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Swisloski ALM. Impaired insulin clearance in essential hypertension. J Hum Hypertens 1994; 8: 185–90.</mixed-citation><mixed-citation xml:lang="en">Swisloski ALM. Impaired insulin clearance in essential hypertension. J Hum Hypertens 1994; 8: 185–90.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Rocchini AP, Moorehead C, Katch V, et al. Forearm resistance vessel abnormalities and insulin resistance in obese adolescents. J Hypertension 1992; 19: 615–20.</mixed-citation><mixed-citation xml:lang="en">Rocchini AP, Moorehead C, Katch V, et al. Forearm resistance vessel abnormalities and insulin resistance in obese adolescents. J Hypertension 1992; 19: 615–20.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Naruse M, Tanabe A, Takagi S, et al. Insulin resistance and vascular function. Nippon Rinsho 2000; 58: 344–7.</mixed-citation><mixed-citation xml:lang="en">Naruse M, Tanabe A, Takagi S, et al. Insulin resistance and vascular function. Nippon Rinsho 2000; 58: 344–7.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Shepherd PR, Kahn BB. Glucose transporter and insulin action. Implications for insulin resistance and diabetes mellitus. N Engl J Med 1999; 341: 248–57.</mixed-citation><mixed-citation xml:lang="en">Shepherd PR, Kahn BB. Glucose transporter and insulin action. Implications for insulin resistance and diabetes mellitus. N Engl J Med 1999; 341: 248–57.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Kumada M, Kihara S, Sumitsuji S, et al. Osaka CAD Study Group. Association of hypoadiponectinemia with coronary heart diseases in men. Arterioscler Tromb Vasc Biol 2003; 23: 85–9.</mixed-citation><mixed-citation xml:lang="en">Kumada M, Kihara S, Sumitsuji S, et al. Osaka CAD Study Group. Association of hypoadiponectinemia with coronary heart diseases in men. Arterioscler Tromb Vasc Biol 2003; 23: 85–9.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Евдокимова А.Г., Радзевич А.Э., Терещенко О.И., Коваленко Е.В. Оценка клинической эффективности включения небиволола и метопролола в комплексную терапию больных ишемической болезнью сердца с хронической сердечной недостаточностью II-III функциональных классов. Кардиоваск тер профил 2005; 4: 52–9.</mixed-citation><mixed-citation xml:lang="en">Евдокимова А.Г., Радзевич А.Э., Терещенко О.И., Коваленко Е.В. Оценка клинической эффективности включения небиволола и метопролола в комплексную терапию больных ишемической болезнью сердца с хронической сердечной недостаточностью II-III функциональных классов. Кардиоваск тер профил 2005; 4: 52–9.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
