cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLCcardiovascular-1654Research ArticleОБЗОРЫREVIEWSЛерканидипин при артериальной гипертензииLercanidipine in arterial hypertensionБорджиK.BorghiC.

Отдел Клинической медицины и прикладной биотехнологии “Де Кампаначи”

Болонья

Clinical Medicine and Applied Biotechnology Department «D. Campanacci» 

Bologna

Университет БолоньиBologna University20090101197087121129Copyright © Борджи K., 19701970Борджи K.Borghi C.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/1654

Лерканидипин – липофильный дигидропиридиновый (ДГП) антагонист кальция (АК) с продолжительным рецепторным периодом полужизни. Замедленное начало действия позволяет предотвратить развитие рефлекторной тахикардии, характерной для других ДГП АК. Лерканидипин обеспечивает равномерный и продолжительный антигипертензивный эффект при приеме 1 раз в сутки. Он обладает эквивалентной антигипертензивной активностью по отношению ко многим другим препаратам, являясь эффективным при монотерапии, так и в комбинации с другими средствами. Эффективность лерканидипина была продемонстрирована у различных возрастных групп пациентов, имеющих дополнительные факторы риска. Лерканидипин хорошо переносится: побочные эффекты, типичные для ДГП АК, возникают в самом начале лечения. На фоне приема лерканидипина частота отеков голеней, приводящих к последующей отмене терапии, ниже, чем при лечении амлодипином и нифедипином-GITS. В доклинических и клинических исследованиях было показано, что лерканидипин обладает антиатеросклеротическим действием и уменьшает гипертрофию левого желудочка. Эффективность и хорошая переносимость лерканидипина делают его препаратом выбора для лечения артериальной гипертензии у различных клинических групп пациентов.

Lercanidipine is a lipophilic dihydropyridine (DHP) calcium antagonist (CA) with a long receptor half-life. The slow action onset prevents reflex tachycardia, typical for other DHP CAs. Taken once a day, lercanidipine provides an even, sustained antihypertensive action. Its antihypertensive activity is equivalent to many other medications, and lercanidipine is effective as monotherapy or in combination. Its effectiveness has been demonstrated in various age groups, as well as in patients with additional risk factors. Lercanidipine is well tolerated, and adverse effects, typical for DHP CAs, are observed early in the treatment. Lercanidipine therapy is associated with lower incidence of pedal oedema and subsequent treatment withdrawal, compared to amlodipine and nifedipine GITS. In preclinical and preliminary clinical trials, lercanidipine demonstrated anti-atherosclerotic effects and left ventricular hypertrophy reduction. Its effectiveness and tolerability profile make lercanidipine a suitable choice for treating various clinical groups of patients with arterial hypertension.

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The authors declare that there are no conflicts of interest present.