References

cardiovascular

Кардиоваскулярная терапия и профилактика

Cardiovascular Therapy and Prevention

1728-88002619-0125

«SILICEA-POLIGRAF» LLC

cardiovascular-1673

Research Article

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Клиническое значение растворимого CD40 лиганда у больных ишемической болезнью сердца

Clinical value of soluble CD40 ligand in coronary heart disease patients

Шевченко

О. П.

Shevchenko

O. P.

Природова

О. Ф.

Prirodova

O. F.

prirodova@mtu8net.ru

Шевченко

А. О.

Shevchenko

A. O.

Российский государственный медицинский университет на базе Клинической больницы Управления делами Президента РФ. МоскваРоссияRussian State Medical University, Clinical Hospital of the Russian Federation President Administration. MoscowRussian Federation

2006

01011970

57101111

1970

Шевченко О.П., Природова О.Ф., Шевченко А.О.

Shevchenko O.P., Prirodova O.F., Shevchenko A.O.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://cardiovascular.elpub.ru/jour/article/view/1673

Воспаление и тромбоз играют важную роль в патогенезе различных сердечно-сосудистых заболеваний (ССЗ). Связь развития атеросклероза и острого коронарного синдрома (ОКС) является двусторонней. Одним из механизмов, связывающих воспаление и тромбообразование, является активация сигнальной системы CD40/CD40L. CD40 и CD40 лиганд (CD40L) - трансмембранные гликопротеиды, относящиеся к семейству рецепторов факторов некроза опухоли и семейству факторов некроза опухоли соответственно. CD40 и CD40L экспрессируются различными клетками, в т.ч. клетками атеросклеротической бляшки: В-лимфоцитами, макрофагами/моноцитами, эндотелиальными и гладкомышечными клетками. Недавно к источникам растворимой формы CD40L (sCD40L) были причислены тромбоциты. В исследованиях последних лет изучалось диагностическое и прогностическое значения sCD40L у больных ишемической болезнью сердца (ИБС). Было показано достоверное увеличение уровней sCD40L y больных инфарктом миокарда и нестабильной стенокардией по сравнению с больными стабильной стенокардией напряжения и здоровыми лицами. Прогностическое значение sCD40L изучено у относительно здоровых женщин, а также у больных с ОКС; высокие уровни sCD40L независимо предсказывали увеличение сердечно-сосудистого риска. Повышение уровней sCD40L в плазме связано с развитием рестеноза после баллонной ангиопластики коронарных артерий. Есть данные о повышенных концентрациях sCD40Ly больных сахарным диабетом, с гиперхолестеринемией, острой ишемией мозга, у курильщиков, а также у пациентов с первичной и вторичной легочной гипертензией. sCD40L можно рассматривать, как маркер воспаления и тромбообразования одновременно, а повышение его уровня является фактором риска ССЗ и связано с неблагоприятным прогнозом у больных ИБС.

Inflammation and thrombosis play an important role in pathogenesis of various cardiovascular diseases (CVD). The studies on atherosclerosis and acute coronary syndrome (ACS) pathogenesis have demonstrated the interaction of these two systems. One of the mechanisms linking inflammation and thrombosis is activation of signal system CD40/CD40L. CD40 and CD40 ligand (CD40L) are transmembrane glycoproteins, related to tumor necrosis factor (TNF) receptor family and TNF family, respectively. CD40 and CD40F are expressed by various cells, including atherosclerotic plaque cells: В-lymphocytes, macrophages/monocytes, endotheliocytes and smooth myocytes. Recently, it has been discovered that platelets can be a source of soluble CD40L form (sCD40FL. In recent clinical trials, diagnostic and prognostic role of sCD40L had been studied in patients with coronary heart disease (CHD). In individuals with myocardial infarction and unstable angina, sCD40L levels are significantly higher than in healthy persons or patients with stable angina. Prognostic sCD40L value was investigated in healthy women and ACS patients; high sCD40L levels independently predicted increased CVD risk. Raised plasma levels of sCD40L are associated with restenosis after balloon coronary angioplasty. Moreover, sCD40L concentrations are increased in Type 1 and 2 diabetes mellitus, hypercholesterolemia, acute cerebral ischemia, smoking, primary and secondary pulmonary hypertension. Therefore, sCD40L could be regarded as inflammation and thrombosis marker. Its increase is a CVD risk factor, associated with poor prognosis in CHD patients.

растворимый СD40 лигандишемическая болезнь сердцафакторы риска

soluble СD40 ligandcoronary heart diseaserisk factors

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The authors declare that there are no conflicts of interest present.