cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLCcardiovascular-1675Research ArticleОБЗОРЫREVIEWSФармакологическая регуляция обмена энергетических субстратов в кардиомиоцитах при патологических состояниях, связанных с ишемиейPharmaceutical regulation of cardiomyocyte energetic substrate metabolism in ischemia8associated pathologyАсташкинЕ. И.AstashkinE. I.glezermg@mtu-net.ruГлезерМ. Г.GlezerM. G.glezermg@mtu-net.ruМосковская медицинская академия им. И.М.Сеченова. МоскваI.M. Sechenov Moscow Medical Academy. Moscow20060101197057112123Copyright © Асташкин Е.И., Глезер М.Г., 19701970Асташкин Е.И., Глезер М.Г.Astashkin E.I., Glezer M.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/1675

Представлен анализ результатов основных исследований, посвященных изучению энергетического метаболизма в кардиомиоцитах (КМЦ) при физиологическом состоянии и ишемии. Особое внимание уделено механизмам регуляции и взаимосвязи между окислением главных энергетических субстратов, а также химическим соединениям и фармакологическим агентам, действующим на ключевые звенья энергетического обмена в условиях ишемии. Лекарственные препараты, которые частично тормозят окисление жирных кислот (ЖК) в миокарде при ишемии, оказывают цитопротективное действие. Важным с точки зрения безопасности их применения в клинических условиях является способность предупреждать аккумуляцию и пагубное воздействие на КМЦ ЖК и их продуктов.

The authors analyze the results of principal studies focused on cardiomyocyte (CMC) energy metabolism in normal physiological state and ischemia. Special emphasis is put on mechanisms of regulation and interaction of main energetic substrate oxidation processes, as well as on chemical substances and pharmaceutical agents affecting key stages of energetic metabolism in ischemia. Medications that partially reduce fatty acid (FA) oxidation in ischemic myocardium, demonstrate cytoprotective action. Their clinical safety is explained by preventing CMC accumulation and toxicity prevention of FT and their products.

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The authors declare that there are no conflicts of interest present.