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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-1736</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Роль кавеол и кавеолинов в норме и патологии</article-title><trans-title-group xml:lang="en"><trans-title>Caveolae and caveolins role in health and disease</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Воробьев</surname><given-names>Р. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Voroblev</surname><given-names>R. I.</given-names></name></name-alternatives><email xlink:type="simple">lenavorobyova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шумахер</surname><given-names>Г. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Shumakher</surname><given-names>G. I.</given-names></name></name-alternatives><email xlink:type="simple">lenavorobyova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хорева</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Khoreva</surname><given-names>M. A.</given-names></name></name-alternatives><email xlink:type="simple">lenavorobyova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Осипова</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Osipova</surname><given-names>I. V.</given-names></name></name-alternatives><email xlink:type="simple">lenavorobyova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кореновский</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Korenovsky</surname><given-names>Yu. V.</given-names></name></name-alternatives><email xlink:type="simple">lenavorobyova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Алтайский государственный медицинский университет, г. Барнаул</institution></aff><aff xml:lang="en"><institution>Altai State Medical University, Barnaul</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2008</year></pub-date><pub-date pub-type="epub"><day>20</day><month>12</month><year>2008</year></pub-date><volume>7</volume><issue>8</issue><fpage>105</fpage><lpage>111</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Воробьев Р.И., Шумахер Г.И., Хорева М.А., Осипова И.В., Кореновский Ю.В., 2008</copyright-statement><copyright-year>2008</copyright-year><copyright-holder xml:lang="ru">Воробьев Р.И., Шумахер Г.И., Хорева М.А., Осипова И.В., Кореновский Ю.В.</copyright-holder><copyright-holder xml:lang="en">Voroblev R.I., Shumakher G.I., Khoreva M.A., Osipova I.V., Korenovsky Y.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/1736">https://cardiovascular.elpub.ru/jour/article/view/1736</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>кавеолы</kwd><kwd>кавеолин</kwd><kwd>холестерин</kwd><kwd>атеросклероз</kwd><kwd>анкагенная трансформация</kwd><kwd>инсулин</kwd><kwd>диабет</kwd></kwd-group><kwd-group xml:lang="en"><kwd>caveolae</kwd><kwd>caveolin</kwd><kwd>cholesterol</kwd><kwd>atherosclerosis</kwd><kwd>cancer transformation</kwd><kwd>insulin</kwd><kwd>diabetes</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Scherer PE, Lisanti MP, Baldini G, et al. (1994) Induction of caveolin during adipogenesis and association of GLUT4 with caveolin-rich vesicles. J Cell Biol 1994; 127: 1233-43.</mixed-citation><mixed-citation xml:lang="en">Scherer PE, Lisanti MP, Baldini G, et al. (1994) Induction of caveolin during adipogenesis and association of GLUT4 with caveolin-rich vesicles. J Cell Biol 1994; 127: 1233-43.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Razani B, Woodman SE, Lisanti MP. Caveolae: From Cell Biology to Animal Physiology. Pharmacol Rev 2002; 54: 431-67.</mixed-citation><mixed-citation xml:lang="en">Razani B, Woodman SE, Lisanti MP. Caveolae: From Cell Biology to Animal Physiology. Pharmacol Rev 2002; 54: 431-67.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Cohen AW, Hnasko R, SchubertW, Lisanti MP. Role of Caveolae and Caveolins in Health and Disease. Physiol Rev 2004; 84: 1341-79.</mixed-citation><mixed-citation xml:lang="en">Cohen AW, Hnasko R, SchubertW, Lisanti MP. Role of Caveolae and Caveolins in Health and Disease. Physiol Rev 2004; 84: 1341-79.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Gil J. Number and distribution of plasmalemmal vesicles in the lung. Fed Proc 1983; 42: 2414-8.</mixed-citation><mixed-citation xml:lang="en">Gil J. Number and distribution of plasmalemmal vesicles in the lung. Fed Proc 1983; 42: 2414-8.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Cameron PL, Ruffin JW, Bollag R, et al. Identification of caveolin and caveolin-related proteins in the brain. J Neurosci 1997; 17: 9520-35.</mixed-citation><mixed-citation xml:lang="en">Cameron PL, Ruffin JW, Bollag R, et al. Identification of caveolin and caveolin-related proteins in the brain. J Neurosci 1997; 17: 9520-35.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Tang ZL, Scherer PE, Okamoto T, et al. Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle. J Biol Chem 1996; 271: 2255-61.</mixed-citation><mixed-citation xml:lang="en">Tang ZL, Scherer PE, Okamoto T, et al. Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle. J Biol Chem 1996; 271: 2255-61.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Drab M, Verkade P, Elger M, et al. Loss of caveolae, vascular dysfunction and pulmonary defects in caveolin-1 gene-disrupted mice. Science (Wash DC) 2001; 293: 2449-52.</mixed-citation><mixed-citation xml:lang="en">Drab M, Verkade P, Elger M, et al. Loss of caveolae, vascular dysfunction and pulmonary defects in caveolin-1 gene-disrupted mice. Science (Wash DC) 2001; 293: 2449-52.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Razani B, Engelman JA, Wang XB, et al. Caveolin-1 null mice are viable, but show evidence of hyper-proliferative and vascular abnormalities. J Biol Chem 2001; 276: 38121-38.</mixed-citation><mixed-citation xml:lang="en">Razani B, Engelman JA, Wang XB, et al. Caveolin-1 null mice are viable, but show evidence of hyper-proliferative and vascular abnormalities. J Biol Chem 2001; 276: 38121-38.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Razani B, Wang XB, Engelman JA, et al. Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae. Mol Cell Biol 2002; 22: 2329-44.</mixed-citation><mixed-citation xml:lang="en">Razani B, Wang XB, Engelman JA, et al. Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae. Mol Cell Biol 2002; 22: 2329-44.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Scherer PE, Okamoto T, Chun M, et al. Identification, sequence and expression of caveolin-2 defines a caveolin gene family. Proc Natl Acad Sci USA 1996; 93: 131-5.</mixed-citation><mixed-citation xml:lang="en">Scherer PE, Okamoto T, Chun M, et al. Identification, sequence and expression of caveolin-2 defines a caveolin gene family. Proc Natl Acad Sci USA 1996; 93: 131-5.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Kurzchalia T, Dupree P, Parton RG, et al. VIP 21, A 21-kD membrane protein is an integral component of trans-Golginetwork-derived transport vesicles. J Cell Biol 1992; 118: 1003-14.</mixed-citation><mixed-citation xml:lang="en">Kurzchalia T, Dupree P, Parton RG, et al. VIP 21, A 21-kD membrane protein is an integral component of trans-Golginetwork-derived transport vesicles. J Cell Biol 1992; 118: 1003-14.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Sargiacomo M, Scherer PE, Tang ZL, et al. Oligomeric structure of caveolin: implications for caveolae membrane organization. Proc Natl Acad Sci USA 1995; 92: 9407-11.</mixed-citation><mixed-citation xml:lang="en">Sargiacomo M, Scherer PE, Tang ZL, et al. Oligomeric structure of caveolin: implications for caveolae membrane organization. Proc Natl Acad Sci USA 1995; 92: 9407-11.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Mora R, Bonilha VL, Marmorstein A, et al. Caveolin-2 localizes to the golgi complex but redistributes to plasma membrane, caveolae and rafts when co-expressed with caveolin-1. J Biol Chem 1999; 274: 25708-17.</mixed-citation><mixed-citation xml:lang="en">Mora R, Bonilha VL, Marmorstein A, et al. Caveolin-2 localizes to the golgi complex but redistributes to plasma membrane, caveolae and rafts when co-expressed with caveolin-1. J Biol Chem 1999; 274: 25708-17.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Das K, Lewis RY, Scherer PE, et al. The membrane spanning domains of caveolins 1 and 2 mediate the formation of caveolin hetero-oligomers. Implications for the assembly of caveolae membranes in vivo. J Biol Chem 1999; 274: 18721-8.</mixed-citation><mixed-citation xml:lang="en">Das K, Lewis RY, Scherer PE, et al. The membrane spanning domains of caveolins 1 and 2 mediate the formation of caveolin hetero-oligomers. Implications for the assembly of caveolae membranes in vivo. J Biol Chem 1999; 274: 18721-8.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Drab M, Verkade P, Elger M, et al. Loss of caveolae, vascular dysfunction and pulmonary defects in caveolin-1 gene-disrupted mice. Science (Wash DC) 2001; 293: 2449-52.</mixed-citation><mixed-citation xml:lang="en">Drab M, Verkade P, Elger M, et al. Loss of caveolae, vascular dysfunction and pulmonary defects in caveolin-1 gene-disrupted mice. Science (Wash DC) 2001; 293: 2449-52.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">GhitescuL, FixmanA, SimonescuM, etal. Specific binding sites for albumin restricted to plasmalemmal vesicles of continuous capillary endothelium: receptor-mediated transcytosis. J Cell Biol 1986; 102: 1304-11.</mixed-citation><mixed-citation xml:lang="en">GhitescuL, FixmanA, SimonescuM, etal. Specific binding sites for albumin restricted to plasmalemmal vesicles of continuous capillary endothelium: receptor-mediated transcytosis. J Cell Biol 1986; 102: 1304-11.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Simionescu N, Simionescu M, and Palade GE. Permeability of muscle capillaries to small heme-peptides: evidence for the existence of patent transendothelial channels. J Cell Biol 1975; 64: 586-607.</mixed-citation><mixed-citation xml:lang="en">Simionescu N, Simionescu M, and Palade GE. Permeability of muscle capillaries to small heme-peptides: evidence for the existence of patent transendothelial channels. J Cell Biol 1975; 64: 586-607.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Schubert W, Frank PG, Razani B, et al. Caveolae-deficient endothelial cells show defects in the uptake and transport of albumin in vivo. J Biol Chem 2001; 276: 48619-22.</mixed-citation><mixed-citation xml:lang="en">Schubert W, Frank PG, Razani B, et al. Caveolae-deficient endothelial cells show defects in the uptake and transport of albumin in vivo. J Biol Chem 2001; 276: 48619-22.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Frank PG, Lee H, Park DS, et al. Genetic ablation of caveolin-1 confers protection against atherosclerosis. Arterioscler Thromb Vasc Biol 2004; 24: 98-105.</mixed-citation><mixed-citation xml:lang="en">Frank PG, Lee H, Park DS, et al. Genetic ablation of caveolin-1 confers protection against atherosclerosis. Arterioscler Thromb Vasc Biol 2004; 24: 98-105.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Lisanti MP, Scherer PE, Vidugiriene J, et al. Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: Implications for human disease. J Cell Biol 1994; 126: 111-26.</mixed-citation><mixed-citation xml:lang="en">Lisanti MP, Scherer PE, Vidugiriene J, et al. Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: Implications for human disease. J Cell Biol 1994; 126: 111-26.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Behrendt D., Ganz P. Endothelial function: from vascular biology to clinical applications. Am J Cardiol 2002; 90: 40-8.</mixed-citation><mixed-citation xml:lang="en">Behrendt D., Ganz P. Endothelial function: from vascular biology to clinical applications. Am J Cardiol 2002; 90: 40-8.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Hailstones D, Sleer LS, Parton RG, and Stanley KK. Regulation of caveolin and caveolae by cholesterol in MDCK cells. J Lipid Res 1998; 39: 369-79.</mixed-citation><mixed-citation xml:lang="en">Hailstones D, Sleer LS, Parton RG, and Stanley KK. Regulation of caveolin and caveolae by cholesterol in MDCK cells. J Lipid Res 1998; 39: 369-79.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Fielding CJ, Bist A, and Fielding PE. Caveolin mRNA levels are up-regulated by free cholesterol and down-regulated by oxysterols in fibroblast monolayers. Proc Natl Acad Sci USA 1997; 94: 3753-8.</mixed-citation><mixed-citation xml:lang="en">Fielding CJ, Bist A, and Fielding PE. Caveolin mRNA levels are up-regulated by free cholesterol and down-regulated by oxysterols in fibroblast monolayers. Proc Natl Acad Sci USA 1997; 94: 3753-8.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Feron O, Dessy C, Desager JP, et al. Hydroxy-methylglutaryl-coenzyme a reductase inhibition promotes endothelial nitric oxide synthase activation through a decrease in caveolin abundance. Circulation 2001; 103 (Absrtract).</mixed-citation><mixed-citation xml:lang="en">Feron O, Dessy C, Desager JP, et al. Hydroxy-methylglutaryl-coenzyme a reductase inhibition promotes endothelial nitric oxide synthase activation through a decrease in caveolin abundance. Circulation 2001; 103 (Absrtract).</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Uittenbogaard A and Smart EJ. Palmitoylation of caveolin-1 is required for cholesterol binding, chaperone complex formation and rapid transport of cholesterol to caveolae. J Biol Chem 2000; 275: 25595-9.</mixed-citation><mixed-citation xml:lang="en">Uittenbogaard A and Smart EJ. Palmitoylation of caveolin-1 is required for cholesterol binding, chaperone complex formation and rapid transport of cholesterol to caveolae. J Biol Chem 2000; 275: 25595-9.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Smart EJ, Ying YS, Donzell WC, et al. A role for caveolin in transport of cholesterol from endoplasmic reticulum to plasma membrane. J Biol Chem 1996, 46: 29427-35.</mixed-citation><mixed-citation xml:lang="en">Smart EJ, Ying YS, Donzell WC, et al. A role for caveolin in transport of cholesterol from endoplasmic reticulum to plasma membrane. J Biol Chem 1996, 46: 29427-35.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Fielding CJ and Fielding PE. Intracellular cholesterol transport. J Lipid Res 1997; 38: 1503-21.</mixed-citation><mixed-citation xml:lang="en">Fielding CJ and Fielding PE. Intracellular cholesterol transport. J Lipid Res 1997; 38: 1503-21.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Fielding CJ and Fielding PE. Cholesterol and caveolae: structural and functional relationships. Biochim Biophys Acta 2000; 1529: 210-22.</mixed-citation><mixed-citation xml:lang="en">Fielding CJ and Fielding PE. Cholesterol and caveolae: structural and functional relationships. Biochim Biophys Acta 2000; 1529: 210-22.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Babitt J, Trigatti B, Rigotti A, et al. Murine SR-BI, a high density lipoprotein receptor that mediates selective lipid uptake, is N-glycosylated and fatty acylated and colocalizes with plasma membrane caveolae. J Biol Chem 1997; 272: 13242-9.</mixed-citation><mixed-citation xml:lang="en">Babitt J, Trigatti B, Rigotti A, et al. Murine SR-BI, a high density lipoprotein receptor that mediates selective lipid uptake, is N-glycosylated and fatty acylated and colocalizes with plasma membrane caveolae. J Biol Chem 1997; 272: 13242-9.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Graf GA, Connell PM, van der Westhuyzen DR, and Smart EJ. The class B, type I scavenger receptor promotes the selective uptake of high density lipoprotein cholesterol ethers into cavoelae. J Biol Chem 1999; 274: 12043-8.</mixed-citation><mixed-citation xml:lang="en">Graf GA, Connell PM, van der Westhuyzen DR, and Smart EJ. The class B, type I scavenger receptor promotes the selective uptake of high density lipoprotein cholesterol ethers into cavoelae. J Biol Chem 1999; 274: 12043-8.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Frank PG, Marcel YL, Connelly MA, et al. Stabilization of caveolin-1 by cellular cholesterol and scavenger receptor class Btype I. Biochemistry 2002; 41: 11931-40.</mixed-citation><mixed-citation xml:lang="en">Frank PG, Marcel YL, Connelly MA, et al. Stabilization of caveolin-1 by cellular cholesterol and scavenger receptor class Btype I. Biochemistry 2002; 41: 11931-40.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Kim M-J, Dawes J, Jessup W. Transendothelial transport of modified low-density lipoproteins. Atherosclerosis 1994; 108: 5-17.</mixed-citation><mixed-citation xml:lang="en">Kim M-J, Dawes J, Jessup W. Transendothelial transport of modified low-density lipoproteins. Atherosclerosis 1994; 108: 5-17.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Pol A, Luetterforst R, Lindsay M, et al. A caveolin dominant negative mutant associates with lipid bodies and induces intracellular cholesterol imbalance. J Cell Biol 2001; 152: 1057-70.</mixed-citation><mixed-citation xml:lang="en">Pol A, Luetterforst R, Lindsay M, et al. A caveolin dominant negative mutant associates with lipid bodies and induces intracellular cholesterol imbalance. J Cell Biol 2001; 152: 1057-70.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Liu P, Ying Y, Zhao Y, et al. Chinese hamster ovary K2 cell lipid droplets appear to be metabolic organelles involved in membrane traffic. J Biol Chem 2004; 279: 3787-92.</mixed-citation><mixed-citation xml:lang="en">Liu P, Ying Y, Zhao Y, et al. Chinese hamster ovary K2 cell lipid droplets appear to be metabolic organelles involved in membrane traffic. J Biol Chem 2004; 279: 3787-92.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Engelman JA, Wycoff CC, Yasuhara S, et al. Recombinant expression of caveolin-1 in oncogenically transformed cells abrogates anchorage-independent growth. J Biol Chem 1997; 272: 16374-81.</mixed-citation><mixed-citation xml:lang="en">Engelman JA, Wycoff CC, Yasuhara S, et al. Recombinant expression of caveolin-1 in oncogenically transformed cells abrogates anchorage-independent growth. J Biol Chem 1997; 272: 16374-81.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Razani B, Schlegel A, and Lisanti MP. Caveolin proteins in signaling, oncogenic transformation and muscular dystrophy. J Cell Sci 2000; 113: 2103-9.</mixed-citation><mixed-citation xml:lang="en">Razani B, Schlegel A, and Lisanti MP. Caveolin proteins in signaling, oncogenic transformation and muscular dystrophy. J Cell Sci 2000; 113: 2103-9.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Engelman JA, Chu C, Lin A, Jo H, et al. Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain. FEBS Lett 1998; 428: 205-11.</mixed-citation><mixed-citation xml:lang="en">Engelman JA, Chu C, Lin A, Jo H, et al. Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain. FEBS Lett 1998; 428: 205-11.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Galbiati F, Engelman JA, Volonte D, et al. Caveolin-3 null mice show a loss of caveolae, changes in the microdomain distribution of the dystrophin-glycoprotein complex, and T-tubule abnormalities. J Biol Chem 2001; 276: 21425-33.</mixed-citation><mixed-citation xml:lang="en">Galbiati F, Engelman JA, Volonte D, et al. Caveolin-3 null mice show a loss of caveolae, changes in the microdomain distribution of the dystrophin-glycoprotein complex, and T-tubule abnormalities. J Biol Chem 2001; 276: 21425-33.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Minetti C, Bado M, Broda P, et al. Impairment of caveolae formation and T-system disorganization in human muscular dystrophy with caveolin-3 deficiency. Am J Pathol 2002; 160: 265-70.</mixed-citation><mixed-citation xml:lang="en">Minetti C, Bado M, Broda P, et al. Impairment of caveolae formation and T-system disorganization in human muscular dystrophy with caveolin-3 deficiency. Am J Pathol 2002; 160: 265-70.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Cao G, Yang G, Timme TL, et al. Disruption of the caveolin-1 gene impairs renal calcium reabsorption and leads to hypercalciuria and urolithiasis. Am J Pathol 2003; 162: 1241-8.</mixed-citation><mixed-citation xml:lang="en">Cao G, Yang G, Timme TL, et al. Disruption of the caveolin-1 gene impairs renal calcium reabsorption and leads to hypercalciuria and urolithiasis. Am J Pathol 2003; 162: 1241-8.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Drab M, Verkade P, Elger M, et al. Loss of caveolae, vascular dysfunction and pulmonary defects in caveolin-1 gene-disrupted mice. Science (Wash DC) 2001; 293: 2449-52.</mixed-citation><mixed-citation xml:lang="en">Drab M, Verkade P, Elger M, et al. Loss of caveolae, vascular dysfunction and pulmonary defects in caveolin-1 gene-disrupted mice. Science (Wash DC) 2001; 293: 2449-52.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Cohen AW, Park DS, Woodman SE, et al. Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts. Am J Physiol Cell Physiol 2003; 284: C457-74.</mixed-citation><mixed-citation xml:lang="en">Cohen AW, Park DS, Woodman SE, et al. Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts. Am J Physiol Cell Physiol 2003; 284: C457-74.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Woodman SE, Park DS, Cohen AW, et al. Caveolin-3 knock out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade. J Biol Chem 2002; 277: 38988-97.</mixed-citation><mixed-citation xml:lang="en">Woodman SE, Park DS, Cohen AW, et al. Caveolin-3 knock out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade. J Biol Chem 2002; 277: 38988-97.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Frank PG, Woodman SE, Park DS, Lisanti MP. Caveolin, caveolae, and endothelial cell function. Arterioscler Thromb VascBiol 2003; 23: 1161-8.</mixed-citation><mixed-citation xml:lang="en">Frank PG, Woodman SE, Park DS, Lisanti MP. Caveolin, caveolae, and endothelial cell function. Arterioscler Thromb VascBiol 2003; 23: 1161-8.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Cybulsky MI, Iiyama K, Li H, et al. A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J Clin Invest 2001; 107: 1255-62.</mixed-citation><mixed-citation xml:lang="en">Cybulsky MI, Iiyama K, Li H, et al. A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J Clin Invest 2001; 107: 1255-62.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Cohen AW, Combs TP, Scherer PE, and Lisanti MP. Role of caveolin and caveolae in insulin signaling and diabetes. Am J Physiol Endocrinol Metab 2003; 285: E1151-60.</mixed-citation><mixed-citation xml:lang="en">Cohen AW, Combs TP, Scherer PE, and Lisanti MP. Role of caveolin and caveolae in insulin signaling and diabetes. Am J Physiol Endocrinol Metab 2003; 285: E1151-60.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Corely-Mastick C and Saltiel AR. Insulin-stimulated tyrosine phosphorylation of caveolin is specific for the differentiated adipocyte phenotype in 3T3-L1 cells. J Biol Chem 1997; 272: 20706-14.</mixed-citation><mixed-citation xml:lang="en">Corely-Mastick C and Saltiel AR. Insulin-stimulated tyrosine phosphorylation of caveolin is specific for the differentiated adipocyte phenotype in 3T3-L1 cells. J Biol Chem 1997; 272: 20706-14.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Gustavsson J, Parpal S, Karlsson M, et al. Localization of the insulin receptor in caveolae of adipocyte plasma membrane. FASEB J 1999; 13: 1961-71.</mixed-citation><mixed-citation xml:lang="en">Gustavsson J, Parpal S, Karlsson M, et al. Localization of the insulin receptor in caveolae of adipocyte plasma membrane. FASEB J 1999; 13: 1961-71.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Parpal S, Karlsson M, Thorn H, and Stralfors P. Cholesterol depletion disrupts caveolae and insulin receptor signaling for metabolic control via insulin receptor substrate-1, but not for mitogen-activated protein kinase control. J Biol Chem 2001; 276: 9670-8.</mixed-citation><mixed-citation xml:lang="en">Parpal S, Karlsson M, Thorn H, and Stralfors P. Cholesterol depletion disrupts caveolae and insulin receptor signaling for metabolic control via insulin receptor substrate-1, but not for mitogen-activated protein kinase control. J Biol Chem 2001; 276: 9670-8.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Razani B, Combs TP, Wang XB, et al. Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities. J Biol Chem 2002; 277: 8635-47.</mixed-citation><mixed-citation xml:lang="en">Razani B, Combs TP, Wang XB, et al. Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities. J Biol Chem 2002; 277: 8635-47.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Bluher M, Michael MD, Peroni OD, et al. Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev Cell 2002; 3: 25-38.</mixed-citation><mixed-citation xml:lang="en">Bluher M, Michael MD, Peroni OD, et al. Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev Cell 2002; 3: 25-38.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
