cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2011-2-98-101cardiovascular-1747Research ArticleМНЕНИЕ ПО ПРОБЛЕМЕOPINION ON A PROBLEMОрганопротективные эффекты хинаприла: фармакогенетические аспектыOrgano-protective effects of quinapril: pharmacogenetic aspectsСычевД. А.SychevD. A.

профессор кафедры клинической фармакологии и пропедевтики внутренних болезней;

начальник сектора персонализированной медицины и клинической фармакогенетики

Москва, Тел.: (495) 915 30 04

dimasychev@mail.ruМуслимоваО. В.MuslimovaO. V.

м.н.с. сектора

Москва

 

Первый Московский государственный медицинский университет им. И.М. Сеченова; Центр клинической фармакологии ФГБУ “НЦ ЭСМП” МинздравсоцразвитияI.M. Sechenov First Moscow State Medical University; Clinical Pharmacology Centre, Research Centre for Drug Expertise and StandardizationЦентр клинической фармакологии ФГБУ “НЦ ЭСМП” МинздравсоцразвитияClinical Pharmacology Centre, Research Centre for Drug Expertise and Standardization20112004201110298101Copyright © Сычев Д.А., Муслимова О.В., 20112011Сычев Д.А., Муслимова О.В.Sychev D.A., Muslimova O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/1747

В обзоре представлены современные данные об органопротективных эффектах ингибитора ангиотензин-превращающего фермента хинаприла, полученные как в экспериментальных, так и клинических исследованиях, которые зависят от I/D полиморфизма гена ACE. В настоящее время есть основания полагать, что именно хинаприл способен модулировать этот генетический фактор риска, который с большой частотой распространен и среди российских пациентов.

The review presents current experimental and clinical evidence on organo-protective effects of an ACE inhibitor quinapril. These effects are dependent on I/D polymorphism of ACE gene. The data available are consistent that quinapril could modulate this genetic risk factor, highly prevalent in Russian patients.

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The authors declare that there are no conflicts of interest present.