cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLCcardiovascular-1787Research ArticleТЕМАТИЧЕСКИЕ СТАТЬИТолщина комплекса интима-медиа сонных артерии и С-реактивный белок у пациентов с абдоминальным ожирениемCarotid intima-media thickness and C-reactive protein in patients with abdominal obesityБеляеваО. Д.BelyaevaO. D.

Докторант, старший научный сотрудник Института ССЗ

БерезинаА. В.BerezinaA. V.

Старший научный сотрудник Института ССЗ

БаженоваЕ. А.BazhenovaE. A.

Докторант

bazhenova@pisem.netМандалВ.MandalV.

Врач-ренгенолог

АнаньеваН. И.AnanyevaN. I.

Заведующая отделением клинико-диагностических исследований

БерковичО. А.BerkovichO. A.

Профессор кафедры факультетской терапии

БарановаЕ. И.BaranovaE. I.

Профессор кафедры факультетской терапии

ШляхтоЕ. В.ShlyakhtoЕ. V.

Заведующий кафедрой факультетской терапии, директор

ГОУ ВПО Санкт-Петербургский Государственный медицинский университет им. академика И.П. Павлова Федерального агентства по здравоохранению и социальному развитиюAcademician I.P. Pavlov St. Petersburg State Medical UniversityГУ Санкт-Петербургский научно-исследовательский психоневрологический институт им. В.М. Бехтерева Министерства здравоохранении РФV.M. Bekhterev St. Petersburg Research Institute of Psycho-neurology200920082009843338Copyright © Беляева О.Д., Березина А.В., Баженова Е.А., Мандал В., Ананьева Н.И., Беркович О.А., Баранова Е.И., Шляхто Е.В., 20092009Беляева О.Д., Березина А.В., Баженова Е.А., Мандал В., Ананьева Н.И., Беркович О.А., Баранова Е.И., Шляхто Е.В.Belyaeva O.D., Berezina A.V., Bazhenova E.A., Mandal V., Ananyeva N.I., Berkovich O.A., Baranova E.I., Shlyakhto Е.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/1787Цель

Цель. Оценить выраженность атеросклероза методом дуплексного сканирования общих сонных артерий (ОСА) и уровни С-реактивного белка (СРБ) у больных с абдоминальным ожирением (АО) в возрасте 30-55 лет.

Материал и методы

Материал и методы. В исследование были включены 203 пациента (средний возраст 45,9+0,5 лет). Из них 152 женщины (средний возраст 45,9+0,8 лет) и 51 мужчина (средний возраст 44,4+1,5 лет) с АО — окружность талии (ОТ) > 80 см у женщин и > 94 см у мужчин. 36,5% пациентов имели избыточную массу тела — индекс массы тела (ИМТ) 28,0+0,2 кг/м2, а 63,5% — ожирение (ИМТ 35,1+0,5 кг/м2). Всем пациентам было проведено ультразвуковое дуплексное сканирование (УЗДС) СА. Содержание СРБ определяли количественным турбидиметрическим методом.

Результаты

Результаты. Для больных с АО характерно раннее развитие атеросклероза СА и повышение уровня СРБ. Атеросклеротические бляшки в ОСА и/или внутренней СА были обнаружены у 39,8% пациентов. Установлена связь между толщиной комплекса интима-медиа (КИМ) ОСА и ОТ а также уровнем инсулина. Выявлена положительная связь между содержанием СРБ и толщиной КИМ, СРБ и уровнем инсулина, СРБ и ОТ СРБ и ИМТ, и отрицательная связь СРБ с концентрацией холестерина липопротеидов высокой плотности.

Заключение

Заключение. Пациентам с АО > 30 лет рекомендовано выполнение УЗДС ОСА для выявления ранних признаков атеросклероза.

Aim

Aim. To assess atherosclerosis severity by duplex ultrasound of common carotid arteries (CCA), as well as C-reactive protein (CRP) levels, in 30-55-year-old patients with abdominal obesity (AO).

Material and methods

Material and methods. The study included 203 patients (mean age 45,9+0,5 years) — 152 women (mean age 45,9+0,8 years) and 51 men (mean age 44,4+1,5 years) with AO (waist circumference, WC, >80 cm in women, >94 cm in men). In total, 36,5% were overweight (body mass index, BMI, 28,0+0,2 kg/m2), and 63,5% were obese (BMI 35,1+0,5 kg/ m2). All participants underwent duplex CA ultrasound (ALOKA SSD-3500, Japan); CRP level was measured by quantitative turbidimetry.

Results

Results. In AO patients, early CA atherosclerosis and increased CRP level were observed. Atherosclerotic plaques in CCA and/or internal CA were found in 39,8%. CCA intima-media thickness (IMT) correlated with WC and insulin level. CRP concentration positively correlated with IMT insulin level, WC, BMI, and negatively correlated with highdensity lipoprotein cholesterol.

Conclusion

Conclusion. In AO patients aged over 30 years, duplex CCA ultrasound should be recommended for early atherosclerosis diagnostics.

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The authors declare that there are no conflicts of interest present.