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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-1800</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Анемия – независимый фактор риска неблагоприятных сердечно-сосудистых исходов у женщин</article-title><trans-title-group xml:lang="en"><trans-title>Anemia – an independent risk factor of adverse cardiovascular outcomes in women</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Терещенко</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Tereshchenko</surname><given-names>S. N.</given-names></name></name-alternatives><email xlink:type="simple">stereschenko@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жиров</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhirov</surname><given-names>I. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ускач</surname><given-names>Т. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Uskach</surname><given-names>T. M.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Московский государственный медико-стоматологический университет Росздрава. Москва</institution></aff><aff xml:lang="en"><institution>Moscow State Medico-Stomatological University, State Federal Agency for Health and Social Development. Moscow</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2006</year></pub-date><pub-date pub-type="epub"><day>01</day><month>01</month><year>1970</year></pub-date><volume>5</volume><issue>8</issue><fpage>117</fpage><lpage>120</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Терещенко С.Н., Жиров И.В., Ускач Т.М., 1970</copyright-statement><copyright-year>1970</copyright-year><copyright-holder xml:lang="ru">Терещенко С.Н., Жиров И.В., Ускач Т.М.</copyright-holder><copyright-holder xml:lang="en">Tereshchenko S.N., Zhirov I.V., Uskach T.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/1800">https://cardiovascular.elpub.ru/jour/article/view/1800</self-uri><abstract><p>Анемия является состоянием, наиболее часто встречающимся у женщин. Наличие анемии служит независимым предиктором неблагоприятного исхода при различных сердечно-сосудистых заболеваниях (ССЗ). Разобраны основные способы коррекции анемии у пациенток с ССЗ, приведены достоинства и недостатки различных терапевтических стратегий.</p><p> </p></abstract><trans-abstract xml:lang="en"><p> Anemia, more prevalent in women than in men, is an independent predictor of cardiovascular disease (CVD) adverse outcomes. Principal methods for anemia correction in CVD patients are discussed; benefits and disadvantages of various therapeutic strategies are considered.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>анемия</kwd><kwd>женщины</kwd><kwd>ишемия миокарда</kwd><kwd>сердечная недостаточность</kwd><kwd>эритропоэтин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>anemia</kwd><kwd>women</kwd><kwd>myocardial ischemia</kwd><kwd>heart failure</kwd><kwd>erythropoietin</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">National Center for Health Statistics. Available at:&lt;http://www.cdc.gov&gt;. Accessed on December 14, 2005.</mixed-citation><mixed-citation xml:lang="en">National Center for Health Statistics. Available at:&lt;http://www.cdc.gov&gt;. Accessed on December 14, 2005.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Sarnak M., Tighiouart H., Manjunath G. et al. Anemia as a risk factor for cardiovascular disease in the Atherosclerosis Risk In Communities (ARIC) study. JACC 2002; 40: 27-33.</mixed-citation><mixed-citation xml:lang="en">Sarnak M., Tighiouart H., Manjunath G. et al. Anemia as a risk factor for cardiovascular disease in the Atherosclerosis Risk In Communities (ARIC) study. JACC 2002; 40: 27-33.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Wu W, Rathore S, Wang Y, et al. Blood transfusion in elderly patients with acute myocardial infarction. N Engl J Med 2001; 345: 123076.</mixed-citation><mixed-citation xml:lang="en">Wu W, Rathore S, Wang Y, et al. Blood transfusion in elderly patients with acute myocardial infarction. N Engl J Med 2001; 345: 123076.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Al-Ahmed A., Rand W., Manjunath G., et al. Reduced kidney function and anemia as risk factors for mortality in patients with left ventricular dysfunction. JACC 2002; 39: 1780-6.</mixed-citation><mixed-citation xml:lang="en">Al-Ahmed A., Rand W., Manjunath G., et al. Reduced kidney function and anemia as risk factors for mortality in patients with left ventricular dysfunction. JACC 2002; 39: 1780-6.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Ezekowitz J., McAlister F., Armstrong R. Anemia is common in eart failure and is associated with poor outcomes: insight from a cohort of 12,065 patients with new-onset heart failure. Circulation 2003; 107: 223-5.</mixed-citation><mixed-citation xml:lang="en">Ezekowitz J., McAlister F., Armstrong R. Anemia is common in eart failure and is associated with poor outcomes: insight from a cohort of 12,065 patients with new-onset heart failure. Circulation 2003; 107: 223-5.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Hampl H., Sternberg C., Berweck S., et al. Regression of left ventricular hypertrophy in hemodialysis patients is possible. Clin Nephrol 2002; 58(Suppl 1): S73-96.</mixed-citation><mixed-citation xml:lang="en">Hampl H., Sternberg C., Berweck S., et al. Regression of left ventricular hypertrophy in hemodialysis patients is possible. Clin Nephrol 2002; 58(Suppl 1): S73-96.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Reis S., Holubkov R., Smith C.A., et al. Coronary microvascular dysfunction is highly prevalent in women with chest pain in the absence of coronary artery disease: results from the NHLBI WISE study. Am Heart J 2001; 141: 735-41.</mixed-citation><mixed-citation xml:lang="en">Reis S., Holubkov R., Smith C.A., et al. Coronary microvascular dysfunction is highly prevalent in women with chest pain in the absence of coronary artery disease: results from the NHLBI WISE study. Am Heart J 2001; 141: 735-41.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Al Falluji N., Lawrence-Nelson J., Kostis J., et al. Myocardial Infarction Data Acquisition System (MIDAS#8) Study Group. Effect of anemia on 1-year mortality in patients with acute myocardial infarction. Am Heart J 2002; 144: 636-41.</mixed-citation><mixed-citation xml:lang="en">Al Falluji N., Lawrence-Nelson J., Kostis J., et al. Myocardial Infarction Data Acquisition System (MIDAS#8) Study Group. Effect of anemia on 1-year mortality in patients with acute myocardial infarction. Am Heart J 2002; 144: 636-41.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Arant C., Wessel T., Olson M., et al. Hemoglobin Level Is an Independent Predictor for Adverse Cardiovascular Outcomes in Women Undergoing Evaluation for Chest Pain. Results From the National Heart, Lung, and Blood Institute Women's Ischemia Syndrome Evaluation Study. JACC 2004; 43: 2009-14.</mixed-citation><mixed-citation xml:lang="en">Arant C., Wessel T., Olson M., et al. Hemoglobin Level Is an Independent Predictor for Adverse Cardiovascular Outcomes in Women Undergoing Evaluation for Chest Pain. Results From the National Heart, Lung, and Blood Institute Women's Ischemia Syndrome Evaluation Study. JACC 2004; 43: 2009-14.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Foley R., Parfrey P., Harnett J., et al. The impact of anemia on cardiomyopathy, morbidity, and mortality in end-stage renal disease. Am J Kidney Dis 1996; 28: 53-61.</mixed-citation><mixed-citation xml:lang="en">Foley R., Parfrey P., Harnett J., et al. The impact of anemia on cardiomyopathy, morbidity, and mortality in end-stage renal disease. Am J Kidney Dis 1996; 28: 53-61.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Metivier F., Marchais S., Guerin A., et al. Pathophysiology of anemia: focus on the heart and blood vessels. Nephrol Dial Transplant 2000; 15(Suppl3): 14-8.</mixed-citation><mixed-citation xml:lang="en">Metivier F., Marchais S., Guerin A., et al. Pathophysiology of anemia: focus on the heart and blood vessels. Nephrol Dial Transplant 2000; 15(Suppl3): 14-8.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Horwich T., Fonarow G., Hamilton M., et al. Anemia Is Associated Wth Worse Symptoms, Greater Impairment in Functional Capacity and a Significant Increase in Mortality in Patients With Advanced Heart Failure. JACC 2002; 39: 1780-6.</mixed-citation><mixed-citation xml:lang="en">Horwich T., Fonarow G., Hamilton M., et al. Anemia Is Associated Wth Worse Symptoms, Greater Impairment in Functional Capacity and a Significant Increase in Mortality in Patients With Advanced Heart Failure. JACC 2002; 39: 1780-6.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">McClellan W., Flanders W., Langston R., et al. Anemia and Renal Insufficiency Are Independent Risk Factors for Death among Patients with Congestive Heart Failure Admitted to Community Hospitals: A Population-Based Study. J Am Soc Nephrol 2002; 13: 1928-36.</mixed-citation><mixed-citation xml:lang="en">McClellan W., Flanders W., Langston R., et al. Anemia and Renal Insufficiency Are Independent Risk Factors for Death among Patients with Congestive Heart Failure Admitted to Community Hospitals: A Population-Based Study. J Am Soc Nephrol 2002; 13: 1928-36.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Ezekowitz J., McAlister F., Armstrong P. Anemia is common in heart failure and is associated with poor outcomes: insights from a cohort of 12 065 patients with new-onset heart failure. Circulation 2003; 107: 223-5.</mixed-citation><mixed-citation xml:lang="en">Ezekowitz J., McAlister F., Armstrong P. Anemia is common in heart failure and is associated with poor outcomes: insights from a cohort of 12 065 patients with new-onset heart failure. Circulation 2003; 107: 223-5.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Androne A., Katz S., Lund L., et al. Hemodilution is common in patients with advanced heart failure. Circulation 2003; 107: 226-9.</mixed-citation><mixed-citation xml:lang="en">Androne A., Katz S., Lund L., et al. Hemodilution is common in patients with advanced heart failure. Circulation 2003; 107: 226-9.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Ezekowitz J., Franijic N., Chang W., et al. What is the relationship between anemia and survival in patients with CHF? A population-based analysis of 29302 patients. Circulation 2002; 106(Suppl II): 11-472.</mixed-citation><mixed-citation xml:lang="en">Ezekowitz J., Franijic N., Chang W., et al. What is the relationship between anemia and survival in patients with CHF? A population-based analysis of 29302 patients. Circulation 2002; 106(Suppl II): 11-472.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Cromie N., Lee C., Struthers A. Anaemia in chronic Heart failure: what is its frequency in the UK and its underlying causes? Heart 2002; 87: 377-8.</mixed-citation><mixed-citation xml:lang="en">Cromie N., Lee C., Struthers A. Anaemia in chronic Heart failure: what is its frequency in the UK and its underlying causes? Heart 2002; 87: 377-8.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Felker G., Stough W., Shaw L., et al. Anaemia and coronary artery disease severity in patients with heart failure. Eur J Heart Failure 2006; 8: 54-7.</mixed-citation><mixed-citation xml:lang="en">Felker G., Stough W., Shaw L., et al. Anaemia and coronary artery disease severity in patients with heart failure. Eur J Heart Failure 2006; 8: 54-7.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Hubert P., Wells G., Blajchman M., et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. N Engl J Med 1999; 340: 409-17.</mixed-citation><mixed-citation xml:lang="en">Hubert P., Wells G., Blajchman M., et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. N Engl J Med 1999; 340: 409-17.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Ely E., Bernard G. Transfusions in critically ill patients. N Engl J Med 1999; 340: 467-8.</mixed-citation><mixed-citation xml:lang="en">Ely E., Bernard G. Transfusions in critically ill patients. N Engl J Med 1999; 340: 467-8.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Welch H., Meehan K., Goodnough L. Prudent strategies for elective red blood cell transfusion. Ann Intern Med 1992; 116: 393-402.</mixed-citation><mixed-citation xml:lang="en">Welch H., Meehan K., Goodnough L. Prudent strategies for elective red blood cell transfusion. Ann Intern Med 1992; 116: 393-402.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Practice guidelines for blood component therapy: a report by the American Society of Anesthesiologists Task Force on Blood Component Therapy. Anesthesiology 1996; 84: 732-47.</mixed-citation><mixed-citation xml:lang="en">Practice guidelines for blood component therapy: a report by the American Society of Anesthesiologists Task Force on Blood Component Therapy. Anesthesiology 1996; 84: 732-47.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Rao S., Jollis J., Harrington R., et al. Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes. JAMA 2004; 292: 1555-62.</mixed-citation><mixed-citation xml:lang="en">Rao S., Jollis J., Harrington R., et al. Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes. JAMA 2004; 292: 1555-62.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Schwengel R., Gottlieb S., Fisher M. Protein-energy malnutrition in patients with ischemic and nonischemic dilated cardiomyopathy and congestive heart failure. Am J Cardiol 1994; 73: 908-10.</mixed-citation><mixed-citation xml:lang="en">Schwengel R., Gottlieb S., Fisher M. Protein-energy malnutrition in patients with ischemic and nonischemic dilated cardiomyopathy and congestive heart failure. Am J Cardiol 1994; 73: 908-10.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">King D., Smith M., Chapman T., et al. Fat malabsorption in elderly patients with cardiac cachexia. Age Ageing 1996; 25: 144-9.</mixed-citation><mixed-citation xml:lang="en">King D., Smith M., Chapman T., et al. Fat malabsorption in elderly patients with cardiac cachexia. Age Ageing 1996; 25: 144-9.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Weil J., Colin J., Langman M., et al. Prophylactic aspirin and risk of peptic ulcer bleeding. Br Med J 1995; 310: 827-30.</mixed-citation><mixed-citation xml:lang="en">Weil J., Colin J., Langman M., et al. Prophylactic aspirin and risk of peptic ulcer bleeding. Br Med J 1995; 310: 827-30.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Silagy C., McNeil J., Donnan G., et al. Adverse effects of low-dose aspirin in a healthy elderly population. Clin Pharmacol Ther 1993; 54: 84-9.</mixed-citation><mixed-citation xml:lang="en">Silagy C., McNeil J., Donnan G., et al. Adverse effects of low-dose aspirin in a healthy elderly population. Clin Pharmacol Ther 1993; 54: 84-9.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Donnelly S., Posen G., Ali M. Oral iron absorption in hemodialysis patients treated with erythropoietin. Clin Invest Med 1991; 14:271-6.</mixed-citation><mixed-citation xml:lang="en">Donnelly S., Posen G., Ali M. Oral iron absorption in hemodialysis patients treated with erythropoietin. Clin Invest Med 1991; 14:271-6.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Goch J., Birgegard G., Danielson B., et al. Iron absorption in patients with chronic uremia on maintenance hemodialysis and in healthy volunteers measured with a simple oral iron load test. Nephron 1996; 73: 403-6.</mixed-citation><mixed-citation xml:lang="en">Goch J., Birgegard G., Danielson B., et al. Iron absorption in patients with chronic uremia on maintenance hemodialysis and in healthy volunteers measured with a simple oral iron load test. Nephron 1996; 73: 403-6.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Kooistra M., Niemantsverdriet E., van Es A., et al. Iron absorption in erythropoietin-treated haemodialysis patients: effects of iron availability, inflammation and aluminum. Nephrol Dial Transplant 1998; 13(1): 882-8.</mixed-citation><mixed-citation xml:lang="en">Kooistra M., Niemantsverdriet E., van Es A., et al. Iron absorption in erythropoietin-treated haemodialysis patients: effects of iron availability, inflammation and aluminum. Nephrol Dial Transplant 1998; 13(1): 882-8.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Macdougall I., Tucker B., Thompson J., et al. A randomized controlled study of iron supplementation in patients treated with erythropoietin. Kidney Int 1996; 50: 1694-9.</mixed-citation><mixed-citation xml:lang="en">Macdougall I., Tucker B., Thompson J., et al. A randomized controlled study of iron supplementation in patients treated with erythropoietin. Kidney Int 1996; 50: 1694-9.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Fishbane S., Frei G., Maesaka J. Reduction in recombinant human erythropoietin doses by the use of chronic intravenous iron supplementation. Am J Kidney Dis 1995; 26: 41-6.</mixed-citation><mixed-citation xml:lang="en">Fishbane S., Frei G., Maesaka J. Reduction in recombinant human erythropoietin doses by the use of chronic intravenous iron supplementation. Am J Kidney Dis 1995; 26: 41-6.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Silverberg D., Blum M., Peer G., et al. Intravenous ferric saccharate as an iron supplement in dialysis patients. Nephron 1996; 72: 413-7.</mixed-citation><mixed-citation xml:lang="en">Silverberg D., Blum M., Peer G., et al. Intravenous ferric saccharate as an iron supplement in dialysis patients. Nephron 1996; 72: 413-7.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Silverberg D., Blum M., Agbaria Z., et al. Intravenous iron for the treatment of predialysis anemia. Kidney Int 1999; 55(Suppl 69): 79-85.</mixed-citation><mixed-citation xml:lang="en">Silverberg D., Blum M., Agbaria Z., et al. Intravenous iron for the treatment of predialysis anemia. Kidney Int 1999; 55(Suppl 69): 79-85.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Silverberg D., Wexler D., Sheps D., et al. The effect of correction of mild anemia in severe, resistant congestive heart failure using subcutaneous erythropoietin and intravenous iron: a randomized controlled study. JACC 2001; 37: 1775-80.</mixed-citation><mixed-citation xml:lang="en">Silverberg D., Wexler D., Sheps D., et al. The effect of correction of mild anemia in severe, resistant congestive heart failure using subcutaneous erythropoietin and intravenous iron: a randomized controlled study. JACC 2001; 37: 1775-80.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Mancini D., Katz S., Lang C. Effect of erythropoietin on exercise capacity in patients with moderate to severe chronic heart failure. Circulation 2003; 107: 294-9.</mixed-citation><mixed-citation xml:lang="en">Mancini D., Katz S., Lang C. Effect of erythropoietin on exercise capacity in patients with moderate to severe chronic heart failure. Circulation 2003; 107: 294-9.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Linde T., Wkstrom B., Andersson L. Renal anaemia treatment with recombinant human erythropoietin increases cardiac output in patients with ischaemic heart disease. Scand J Urol Nephrol 1996; 30:115-20.</mixed-citation><mixed-citation xml:lang="en">Linde T., Wkstrom B., Andersson L. Renal anaemia treatment with recombinant human erythropoietin increases cardiac output in patients with ischaemic heart disease. Scand J Urol Nephrol 1996; 30:115-20.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Low-Friedrich I., Grutzmacher P., Marz W. Therapy with recombinant human erythropoietin reduces cardiac size and improves heart function in chronic hemodialysis patients. Am J Nephrol 1991; 11:54-60.</mixed-citation><mixed-citation xml:lang="en">Low-Friedrich I., Grutzmacher P., Marz W. Therapy with recombinant human erythropoietin reduces cardiac size and improves heart function in chronic hemodialysis patients. Am J Nephrol 1991; 11:54-60.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Goldberg N., Lundin A., Delano B. Changes in left ventricular size, wall thickness, and function in anemic patients treated with recombinant human erythropoietin. Am Heart J 1992; 124: 424-7.</mixed-citation><mixed-citation xml:lang="en">Goldberg N., Lundin A., Delano B. Changes in left ventricular size, wall thickness, and function in anemic patients treated with recombinant human erythropoietin. Am Heart J 1992; 124: 424-7.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Foley R., Parfrey P., Morgan J., et al. A randomized controlled trial of complete vs partial correction of anemia in hemodialysis patients with asymptomatic concentric LV hypertrophy or LV dilatation. J Am Soc Nephrol 1998; 9: 208-10.</mixed-citation><mixed-citation xml:lang="en">Foley R., Parfrey P., Morgan J., et al. A randomized controlled trial of complete vs partial correction of anemia in hemodialysis patients with asymptomatic concentric LV hypertrophy or LV dilatation. J Am Soc Nephrol 1998; 9: 208-10.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Wald M., Gutnisky A., Borda E. Erythropoietin modified the cardiac action of ouabain in chronically anaemic uraemic rats. Nephron 1995; 71: 190-6.</mixed-citation><mixed-citation xml:lang="en">Wald M., Gutnisky A., Borda E. Erythropoietin modified the cardiac action of ouabain in chronically anaemic uraemic rats. Nephron 1995; 71: 190-6.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Wald M., Borda E., Sterin-Borda L. Mitogenic effect of erythropoietin on neonatal rat cardiomyocytes: signal transduction pathways. J Cell Physiol 1996; 167: 461-8.</mixed-citation><mixed-citation xml:lang="en">Wald M., Borda E., Sterin-Borda L. Mitogenic effect of erythropoietin on neonatal rat cardiomyocytes: signal transduction pathways. J Cell Physiol 1996; 167: 461-8.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Wu H., Lee S., Liu X. Inactivation of erythropoietin leads to defects in cardiac morphogenesis. Dvelopment 1999; 126: 3597-605.</mixed-citation><mixed-citation xml:lang="en">Wu H., Lee S., Liu X. Inactivation of erythropoietin leads to defects in cardiac morphogenesis. Dvelopment 1999; 126: 3597-605.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Kuriyama S., Hopp L., Yoshida H., et al. Evidence for amelioration of endothelial cell dysfunction by erythropoietin therapy in predialysis patients. Am J Hypertens 1996; 9: 426-31.</mixed-citation><mixed-citation xml:lang="en">Kuriyama S., Hopp L., Yoshida H., et al. Evidence for amelioration of endothelial cell dysfunction by erythropoietin therapy in predialysis patients. Am J Hypertens 1996; 9: 426-31.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Sowade O., Gross J., Sowade B., et al. Evaluation of oxygen availability with oxygen status algorithm in patients undergoing open heart surgery treated with epoetin beta. J Lab Clin Med 1997; 129:97-105.</mixed-citation><mixed-citation xml:lang="en">Sowade O., Gross J., Sowade B., et al. Evaluation of oxygen availability with oxygen status algorithm in patients undergoing open heart surgery treated with epoetin beta. J Lab Clin Med 1997; 129:97-105.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Silverberg D.S., Wexler D., Blum M. The Use of Subcutaneous Erythropoietin and Intravenous Iron for the Treatment of the Anemia of Severe, Resistant Congestive Heart Failure Improves Cardiac and Renal Function and Functional Cardiac Class, and Markedly Reduces Hospitalizations. JACC 2000; 35: 1737-44.</mixed-citation><mixed-citation xml:lang="en">Silverberg D.S., Wexler D., Blum M. The Use of Subcutaneous Erythropoietin and Intravenous Iron for the Treatment of the Anemia of Severe, Resistant Congestive Heart Failure Improves Cardiac and Renal Function and Functional Cardiac Class, and Markedly Reduces Hospitalizations. JACC 2000; 35: 1737-44.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
