cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2012-3-77-81cardiovascular-1822Research ArticleМНЕНИЕ ПО ПРОБЛЕМЕOPINION ON A PROBLEMРоль витамина D в развитии артериальной гипертензииVitamin D role in arterial hypertension developmentДудинскаяЕ. Н.DudinskayaE. N.katharina.gin@gmail.comТкачеваО. Н.TkachevaO. N.tkacheva@rambler.ruФГБУ «Государственный научно-исследовательский центр профилактической медицины» Минздравсоцразвития России, МоскваState Research Centre for Preventive Medicine, Moscow2012200620121137781Copyright © Дудинская Е.Н., Ткачева О.Н., 20122012Дудинская Е.Н., Ткачева О.Н.Dudinskaya E.N., Tkacheva O.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/1822

В последние годы получены данные о возможных механизмах, связанных с D-эндокринной системой, которые участвуют в регуляции в т.ч. уровня артериального давления. Дефицит витамина D ассоциируется с нарушением кальциевого обмена, повышением тонуса ренин-ангиотензин-альдостероновой системы, дисфункцией эндотелия, формированием метаболического синдрома. Представленные результаты исследований открывают перспективу применения созданного на основе витамина D нового класса антигипертензивных препаратов. Целью данного обзора стало представление связанных с обменом витамина D в организме человека механизмов развития артериальной гипертензии.

Recently obtained data have identified potential mechanisms linking D-endocrine system and blood pressure regulation. Vitamin D deficiency is associated with calcium metabolism disregulation, increased tonus of renin-angiotensin-aldosterone system, endothelial dysfunction, and metabolic syndrome development. The evidence presented suggests a possibility for developing a new, vitamin D-derived class of antihypertensive medications. This review discusses the mechanisms of arterial hypertension development which are related to vitamin D metabolism in humans.

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The authors declare that there are no conflicts of interest present.