cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2012-4-65-69cardiovascular-1867Research ArticleЭПИДЕМИОЛОГИЯ И ПРОФИЛАКТИКААссоциации между С-реактивным белком и артериальным давлением в когорте пожилых москвичей (эпидемиологическое исследование)Association between C-reactive protein and blood pressure in a cohort of elderly Muscovites: epidemiological study dataШальноваС. А.ShalnovaS. A.vika_gukova@mail.ruЖуковаВ. А.ZhukovaV. A.vika_gukova@mail.ruМетельскаяВ. А.MetelskayaV. A.vika_gukova@mail.ruДеевА. Д.DeevA. D.vika_gukova@mail.ruХудяковМ. Б.KhudyakovM. B.vika_gukova@mail.ruАлександриА. Л.AleksandriA. L.vika_gukova@mail.ruБалановаЮ. А.BalanovaYu. A.vika_gukova@mail.ruКапустинаА. В.KapustinaA. V.vika_gukova@mail.ruКонстантиновВ. В.KonstantinovV. V.vika_gukova@mail.ruКукушкинС. К.KukushkinS. K.vika_gukova@mail.ruПлатоноваЕ. В.PlatonovaE. V.vika_gukova@mail.ruШкольниковаМ. А.ShkolnikovaM. A.vika_gukova@mail.ruКиселеваН. В.KiselevaN. V.vika_gukova@mail.ruФГБУ Государственный научно-исследовательский центр профилактической медициныState Research Centre for Preventive MedicineФГБУ Московский научно-исследовательский институт педиатрии и детской хирургии, МоскваMoscow Research Institute of Pediatrics and Child Surgery, Moscow2012200820121146569Copyright © Шальнова С.А., Жукова В.А., Метельская В.А., Деев А.Д., Худяков М.Б., Александри А.Л., Баланова Ю.А., Капустина А.В., Константинов В.В., Кукушкин С.К., Платонова Е.В., Школьникова М.А., Киселева Н.В., 20122012Шальнова С.А., Жукова В.А., Метельская В.А., Деев А.Д., Худяков М.Б., Александри А.Л., Баланова Ю.А., Капустина А.В., Константинов В.В., Кукушкин С.К., Платонова Е.В., Школьникова М.А., Киселева Н.В.Shalnova S.A., Zhukova V.A., Metelskaya V.A., Deev A.D., Khudyakov M.B., Aleksandri A.L., Balanova Y.A., Kapustina A.V., Konstantinov V.V., Kukushkin S.K., Platonova E.V., Shkolnikova M.A., Kiseleva N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/1867

Актуальность проблемы. Повышение артериального давления (АД) влияет на возникновение воспаления в сосудистой стенке. Вместе с тем, существует мнение, что воспаление само по себе может быть независимым фактором риска (ФР) развития артериальной гипертензии (АГ). Цель. Изучить, являются ли ассоциации повышенного уровня С-реактивного белка (СРБ) с АГ независимыми от традиционных ФР. Материал и методы. Результаты получены в рамках одномоментного исследования, включающего 1876 (47,9% мужчин) москвичей в возрасте ≥ 55 лет, участников проспективного исследования «Стресс, старение и здоровье». В ходе исследования изучались социально-демографические характеристики, поведенческие привычки, регистрировались антропометрические показатели и ЭКГ в покое, измерялось АД, определялись показатели липидного обмена. В качестве зависимой переменной использовался уровень СРБ > 3 мг/л. Статистический анализ включал метод логистической регрессии, отношение шансов (ОШ) и 95% доверительный интервал (95% ДИ). Результаты. Выявлены положительные ассоциации между АГ и СРБ > 3 мг/л. В модели, стандартизованной на пол и возраст, ОШ СРБ > 3 мг/л у лиц с АГ в сравнении с референсной группой составило 1,688 (1,323, 2,154) (p=0,0001). В полной модели, включающей пол, возраст, уровень образования, курение, употребление легких спиртных напитков, абдоминальное ожирение, высокий индекс атерогенности, наличие ИБС, ОШ осталось статистически значимым 1,450 (1.127, 1.864) p=0,004. Заключение. Положительные ассоциации повышенного уровня СРБ с повышенным уровнем АД у пожилых москвичей не зависят от ФР и ИБС.

Background. The elevation of blood pressure (BP) affects the development of vascular inflammation. At the same time, it has been suggested that inflammation itself could be an independent risk factor (RF) of arterial hypertension (AH) development. Aim. To investigate whether the association between increased levels of C-reactive protein (CRP) and AH is independent from classical RFs. Material and methods. The data were obtained during a crosssectional survey of 1876 Muscovites (47,9% men) aged ≥55 years, who participated in the prospective study “Stress, Ageing, and Health in Russia”. In all participants, socio-demographic characteristics, health behaviours, parameters of anthropometry and rest electrocardiography (ECG) were assessed. The levels of BP and blood lipids were also measured. The outcome variable was an increase in CRP levels (>3 mg/l). Statistical methods included logistic regression; the risk estimates were presented as odds ratios (OR) and 95% confidence intervals (CI). Results. There was a positive link between AH and CRP levels of >3 mg/l. After adjustment for age and sex, OR of increased CRP levels in hypertensive participants vs. their AH-free peers was 1,688 (95% CI 1,323-2,154; p=0,0001). In the final model (adjustment for age, sex, educational level, smoking, alcohol consumption, abdominal obesity, high atherogenicity index, and coronary heart disease, CHD), this effect remained statistically significant (OR 1,450; 95% CI 1,127-1,864; p=0,004). Conclusion. In elderly Muscovites, a positive association between increased CRP levels and the elevation of BP was independent from RFs and CHD.

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The authors declare that there are no conflicts of interest present.