cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLCcardiovascular-1872Research ArticleОБЗОРЫREVIEWSБиохимическим, структурный и клиническим анализ плейотропных эффектов статиновBiochemical, structural and clinical analysis of statins’ pleiotropic effectsБритовА. Н.BritovA. N.

Ведущий научный сотрудник отдела разработки клинических методов вторичной профилактики.

Москва

Moscow

ГомазковО. А.GomazkovO. A.

Главный научный сотрудник.

Москва, тел.: (495) 938-07-36

Moscow

oleg-gomazkov@yandex.ruГосударственный научно-исследовательский центр профилактической медицины РосмедтехнологииState Research Centre for Preventive Medicine, Federal Agency on High Medical TechnologiesНИИ биологической и медицинской химии им. В.Н.Ореховича РАМНV.N. Orekhovich Research Institute of Biological and Medical Chemistry, Russian Academy of Medical Sciences2009201020098592102Copyright © Бритов А.Н., Гомазков О.А., 20092009Бритов А.Н., Гомазков О.А.Britov A.N., Gomazkov O.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/1872

Предпринята попытка на основании анализа результатов клинических и экспериментальных исследова­ний выстроить доказательную линию плейотропного действия статинов, которое подразумевает включение нескольких механизмов реализации их активности. Понятие плейотропности предполагает: (а) влияние препарата на несколько мишеней, запускающее различные биохимические процессы в организме; (б) дивергенцию биохимических и патофизиологических процессов, исходящих от основной (единственной) мишени. Описаны патохимические механизмы эффектов статинов, как ингибиторов фермента редуктазы коэнзима А, с обоснованием того, что терапевтическое и побочное действия статинов не обязательно связаны с их влиянием на метаболизм липидов и снижением уровня холестерина.

Based on the analysis of clinical and experimental studies, an attempt to explain pleiotropic effects of statins and their numerous action mechanisms has been performed. The pleiotropic effect concept includes: (a) medication effects on numerous targets, triggering various biochemical processes in the organism; b) the divergence of bio­chemical and pathophysiological processes triggered by one target. The pathochemical mechanisms of statins’ effects as HMG-CoA reductase inhibitors are explained. The authors also justify the independence of therapeutic and adverse effects of statins from their lipid and cholesterol-related mechanisms of action.

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The authors declare that there are no conflicts of interest present.