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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1728-8800-2011-5-57-62</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-1939</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АРИТМИИ СЕРДЦА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ARRHYTHMIAS</subject></subj-group></article-categories><title-group><article-title>Частота желудочковых аритмий и возможности их лечения препаратом омега-3 полиненасыщенных жирных кислот у больных в течение года после инфаркта миокарда</article-title><trans-title-group xml:lang="en"><trans-title>Ventricular arrhythmia prevalence and treatment with omega-3 polyunsaturated fatty acids in patients who suffered myocardial infarction within the last year</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гоголашвили</surname><given-names>Н. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Gogolashvili</surname><given-names>N. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>в.н.с. клинического отделения мониторинга соматической патологии и прогнозирования здоровья</p><p>Красноярск </p></bio><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Литвиненко</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Litvinenko</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>очный аспирант по специальности кардиология</p><p>Красноярск </p></bio><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Почикаева</surname><given-names>Т. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Pochikaeva</surname><given-names>T. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>очный аспирант по специальности кардиология</p><p>Красноярск, Тел.: 8 (391) 256-81-14 </p></bio><bio xml:lang="en"/><email xlink:type="simple">ptn-09@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вавитова</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Vavitova</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>очный аспирант по специальности кардиология</p><p>Красноярск</p></bio><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Поликарпов</surname><given-names>Л. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Polikarpov</surname><given-names>L. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>руководитель клинического отделения мониторинга соматической патологии и прогнозирования здоровья</p><p>Красноярск </p></bio><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Новгородцева</surname><given-names>Н. Я.</given-names></name><name name-style="western" xml:lang="en"><surname>Novgorodtseva</surname><given-names>N. Ya.</given-names></name></name-alternatives><bio xml:lang="ru"><p>с.н.с. клинического отделения мониторинга соматической патологии и прогнозирования здоровья</p><p>Красноярск </p></bio><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Учреждение РАМН НИИ медицинских проблем Севера СО РАМН</institution></aff><aff xml:lang="en"><institution>Research Institute of Medical Problems of the North, Siberian Branch, Russian Academy of Medical Sciences</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>20</day><month>10</month><year>2011</year></pub-date><volume>10</volume><issue>5</issue><fpage>57</fpage><lpage>62</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гоголашвили Н.Г., Литвиненко М.В., Почикаева Т.Н., Вавитова Е.С., Поликарпов Л.С., Новгородцева Н.Я., 2011</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="ru">Гоголашвили Н.Г., Литвиненко М.В., Почикаева Т.Н., Вавитова Е.С., Поликарпов Л.С., Новгородцева Н.Я.</copyright-holder><copyright-holder xml:lang="en">Gogolashvili N.G., Litvinenko M.V., Pochikaeva T.N., Vavitova E.S., Polikarpov L.S., Novgorodtseva N.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/1939">https://cardiovascular.elpub.ru/jour/article/view/1939</self-uri><abstract><p>Цель. Изучить частоту желудочковых аритмий (ЖА) у больных в течение года после инфаркта миокарда (ИМ), оценить лечение препаратом омега-3 полиненасыщенных жирных кислот (ПНЖК) в течение 6 мес. Материал и методы. Обследованы 370 пациентов после ИМ, проводилось холтеровское мониторирование (ХМ) электрокардиограммы с оценкой ЖА в зависимости от пола и возраста. Выделено 56 пациентов с желудочковыми экстрасистолами (ЖЭ) от 500 до 1000 за сут.: I группа (гр.) (n=30) — получали омега-3 ПНЖК 1 г/сут. в течение 6 мес.; II гр. (контрольная — ГК) (n=26). Результаты. У больных с ЖА среднее количество ЖЭ — 374,6. Увеличивалось количество ЖЭ с возрастом: со 185,4 ЖЭ у пациентов 30-59 лет до 574,3 ЖЭ у больных ≥ 60 лет (р=0,002). У мужчин в возрасте ≥ 60 лет количество ЖЭ за сут. больше, чем у мужчин 30-59 лет (р=0,001). Через 6 мес. у пациентов, принимавших омега-3 ПНЖК, снизилось количество ЖЭ с 699 до 139 (р=0,004), частая ЖЭ с 93,3 % до 40 % (р=0,00001), парная ЖЭ с 83,3 % до 46,7 % (р=0,003), 4Б градация с 50 % до 20 % (р=0,02), частота высоких градаций ЖЭ (3-5) с 83,3 % до 50 % (р=0,006). В ГК положительная динамика отсутствовала. Заключение. У большинства больных в течение года после ИМ регистрируются редкие ЖЭ. Увеличивается частота и количество ЖЭ с возрастом у мужчин и в обследованной гр. в целом. У женщин с возрастом увеличивается частота ЖА. Через 6 мес. у пациентов, принимающих омега-3 ПНЖК, снижаются количество ЖЭ за сут., частота градаций 2, 3, 4А, 4Б и высоких градаций ЖЭ в целом, в ГК возросла 4Б градация.</p></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To study the prevalence of ventricular arrhythmias (VA) in the patients who suffered myocardial infarction (MI) within the last year; to evaluate the effects of the treatment with omega-3 polyunsaturated fatty acids (PUFA) for 6 months. Material and methods. In total,370 MI patients underwent 24-hour Holter monitoring of electrocardiogram (ECG), with the subsequent VA analysis by age and gender. Fifty six patients had 500-100 ventricular extrasystoles (VE) registered in 24 hours. Group I (n=30) received omega-3 PUFA (1 g/d) for 6 months; Group II patients (n=26) were controls.</p></sec><sec><title>Results</title><p>Results. In patients with VA, the mean number of VE reached 374,6. The daily VE number increased with age: from 185,4 in people aged 30-59 years to 574,3 in participants aged 60 years or older (р=0,002). In men aged ≥60 years, the daily VE number was greater than in men aged 30-59 years (р=0,001). After 6 months of the omega-3 PUFA treatment, Group I demonstrated reduced prevalence of all VE (from 699 to 139; р=0,004), as well as a decrease in the percentage of frequent VE (from 93,3 % to 40 %; р=0,00001), paired VE (from 83,3 % to 46,7 %; р=0,003), Grade 4B VE (from 50 % to 20 %; р=0,02), and all high-grade (3-5) VE (from 83,3 % to 50 %; р=0,006). No positive dynamics was observed for the control Group II. Conclusion. In most patients who suffered MI within the last year, the prevalence of VE was relatively low. The VA prevalence and daily VE number increased with age, both in all examined patients and in men only. In women, advanced age was linked to an increased VA prevalence. Omega-3 PUFA treatment for 6 months was associated with a reduction in the daily VE number and the prevalence of Grade 2, 3, 4A, 4B, and all high-grade VE. In the controls, the prevalence of Grade 4B VE increased.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>инфаркт миокарда</kwd><kwd>желудочковые нарушения ритма</kwd><kwd>омега-3 полиненасыщенные жирные кислоты</kwd><kwd>холтеровское мониторирование</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Myocardial infarction</kwd><kwd>ventricular arrhythmias</kwd><kwd>omega-3 polyunsaturated fatty acids</kwd><kwd>Holter ECG monitoring</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bigger JTJr, Fleiss JL, Kleiger R, et al. The Multicenter Postinfarction Research Group. The relationships among ventricular arrhythmias, left ventricular dysfunction and mortality in the 2 years after myocardial infarction. Circulation 1984; 69: 250-8.</mixed-citation><mixed-citation xml:lang="en">Bigger JTJr, Fleiss JL, Kleiger R, et al. The Multicenter Postinfarction Research Group. 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