cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2011-6-24-29cardiovascular-1958Research ArticleАРТЕРИАЛЬНАЯ ГИПЕРТОНИЯARTERIAL HYPERTENSIONВозможности коррекции гиперурикемии лозартаном при метаболическом синдроме и артериальной гипертензииLosartan therapy and hyperuricemia correction in patients with metabolic syndrome and arterial hypertensionНедогодаС. В.NedogodaS. V.

д. м. н., профессор, зав. кафедрой терапии и эндокринологии

Волгоград, Тел.: 8- 902-364-32-26

Volgograd

nedogodasv@ranbler.ruЧумачокЕ. В.ChumachokE. V.

аспирант кафедры

Волгоград

Volgograd

ЛедяеваА. А.LedyaevaA. A.

аспирант кафедры

Волгоград

Volgograd

ЦомаВ. В.TsomaV. V.

ассистент кафедры

Волгоград

Volgograd

Волгоградский государственный медицинский университетVolgograd State Medical University2011201220111062429Copyright © Недогода С.В., Чумачок Е.В., Ледяева А.А., Цома В.В., 20112011Недогода С.В., Чумачок Е.В., Ледяева А.А., Цома В.В.Nedogoda S.V., Chumachok E.V., Ledyaeva A.A., Tsoma V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/1958

Цель. Оценить возможности коррекции гиперурикемии (ГУ) у пациентов с артериальной гипертензией (АГ) и метаболическим синдромом (МС) при назначении блокатора рецепторов ангиотензина II лозартана. Материалы и методы. В открытое, рандомизируемое, контролируемое, сравнительное исследование в параллельных группах (лозартан vs традиционной терапии на протяжении 12 нед.) были включены 60 больных АГ с МС и ГУ. Результаты. Общей закономерностью, выявленной на всех сроках лечения, оказалось то, что достоверных различий между группами лозартана и традиционной терапии по антигипертензивной активности выявлено не было. В группе лозартана было отмечено значительно большее снижение уровня мочевой кислоты (МК) — 34,7 % vs 7,8 % в группе традиционной терапии (р < 0,05); также имело место достоверное улучшение эластичности сосудов мышечного и эластического типов, что проявилось снижением СПВ на соответствующих режимах терапии: каротидно-феморальный — на 27,8 % vs 8,1 % (р < 0,05) и каротидно-радиальной — на 30,2 % и 12,6 % (р < 0,05). Заключение. Большее снижение уровня МК у пациентов с АГ, МС и ГУ, что приводит к достоверно большему улучшению эластичности сосудов.

Aim. To assess the potential of the angiotensin II receptor antagonist losartan for the correction of hyperuricemia (HU) in patients with arterial hypertension (AH) and metabolic syndrome (MS). Material and methods. This open, randomised, controlled comparative study in parallel groups included 60 AH patients with MS and HU. The patients received losartan or standard therapy for 12 weeks. Results. Throughout the follow-up period, no significant difference in antihypertensive effect was observed between the losartan and standard therapy groups. Losartan group patients demonstrated a more pronounced decrease in uric acid levels (-34,7 % vs. -7,8 % in the standard therapy group; p<0,05). In addition, losartan therapy, compared to the standard treatment, was associated with improved vascular elasticity, as manifested by the pulse wave velocity decrease (-27,8 % vs. -8,1 % for carotid-femoral index, and -30,2 % vs. -12,6 % for carotidradial index, respectively; both p<0,05).

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The authors declare that there are no conflicts of interest present.