cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2011-6-94-98cardiovascular-1976Research ArticleМНЕНИЕ ПО ПРОБЛЕМЕOPINION ON A PROBLEMРоль вазодилатирующих β-адреноблокаторов в терапии пациентов с осложненной гипертензией: фокус на небивололThe role of vasodilating β-blockers in patients with complicated hypertension: focus on nebivololЖильТ. Д.GilesT. D.

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New Orleans, Louisiana

Отделение медицины, медицинская школа Университета ТуланаDepartment of Medicine, Tulane University School of Medicine2011201220111069498Copyright © Жиль Т.Д., 20112011Жиль Т.Д.Giles T.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/1976

Несмотря на доказанную эффективность β-адреноблокаторов (β-АБ) в снижении риска заболеваемости и смертности, их применение у пациентов с сопутствующей сердечно-сосудистой патологией остается ограниченным. Недостаточно частое назначение β-АБ может быть связано с опасениями, основанными на плохой переносимости старых представителей этого класса препаратов. β-АБ с вазодилатирующими свойствами, такие как карведилол и небиволол, обладают лучшей переносимостью и не вызывают неблагоприятные метаболические эффекты, в отличие от традиционных β-АБ. Поскольку эндотелиальная дисфункция как ведущая патофизиологическая характеристика артериальной гипертензии (АГ) сильнее выражена в клинических популяциях, плохо реагирующих на терапию АГ (например, у пожилых и пациентов афро-американского происхождения), вазодилатирующие β-АБ могут стать наиболее показанными препаратами при лечении таких больных.

Despite their proven mortality and morbidity outcomes benefits, β-blockers remain substantially underused in patients with cardiac conditions. Reluctance to prescribe β-blockers may be owing to concerns about tolerability with the traditional drugs in this class. β-blockers with vasodilatory properties, such as carvedilol and nebivolol, may overcome the tolerability and metabolic issues associated with traditional β-blockers. Because endothelial dysfunction, the pathophysiologic hallmark of hypertension, may be heightened in populations with difficult-totreat hypertension (e.g., elderly patients, African American patients), a vasodilating β-blocker may be a particularly appropriate choice for these patient groups.

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The authors declare that there are no conflicts of interest present.