References

cardiovascular

Кардиоваскулярная терапия и профилактика

Cardiovascular Therapy and Prevention

1728-88002619-0125

«SILICEA-POLIGRAF» LLC

10.15829/1728-8800-2011-6-99-104

cardiovascular-1977

Research Article

МНЕНИЕ ПО ПРОБЛЕМЕ

OPINION ON A PROBLEM

Безопасность и эффективность сульфгидрильного ингибитора ангиотензин-превращающего фермента зофеноприла в лечении сердечно-сосудистых заболеваний

Safety and efficacy of the sulfydryl ACE-inhibitor zofenopril in the management of cardiovascular disease

Наполи

К.

Napoli

Отделение общей патологии, научно-исследовательский центр клинической патологии сердечнососудистых заболеваний, 1-я Школа медицины, Университет НеаполяDepartment of General Pathology, Division of Clinical Pathology and Excellence Research Centre on Cardiovascular Disease 1st School of Medicine, II University of Naples

2011

20122011

10699104

2011

Наполи К.

Napoli C.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://cardiovascular.elpub.ru/jour/article/view/1977

Начиная с 1970-х гг., медикаментозная терапия, подавляющая влияние ренин-ангиотензин-альдостероновой системы (РААС), рассматривалась в качестве эффективного метода лечения больных с высокорениновой гипертензией (АГ). Позднее было показано, что ингибиторы ангиотензин-превращающего фермента (ИАПФ) эффективны не только у пациентов с высокими уровнями ренина и артериального давления (АД), но и у значительной части больных АГ и нормальными значениями активности ренина плазмы (АРП). ИАПФ применяются для лечения целого ряда хронических заболеваний, таких как атеросклероз, АГ, инфаркт миокарда (ИМ), сердечная недостаточность, осложнения сахарного диабета и инсульт. В настоящее время выполнено более 90 контролируемых, клинических исследований по оценке благоприятных терапевтических эффектов 14 различных молекул ИАПФ. Согласно данным экспериментальных исследований, ИАПФ способны замедлять развитие атеросклероза, уменьшать выраженность окислительного стресса (ОС) и сосудистого воспаления у лабораторных животных различных видов. Это свидетельствует о том, что ИАПФ оказывают благоприятное действие на состояние кровеносных сосудов. Более 15 лет назад сульфгидрильный ИАПФ зофеноприл продемонстрировал отличную клиническую эффективность и безопасность у пациентов с АГ и больных ИМ. Не так давно были выявлены выраженные антиокислительное и антиатеросклеротическое действия этого препарата, что свидетельствует о наличии клинически значимого вазопротективного эффекта.

In the 1970s, pharmacological therapy interrupting the renin-angiotensin system was considered beneficial for patients with high-renin hypertension. Angiotensin-converting enzyme (ACE) inhibitors proved to be effective not only in patients with high renin and elevated blood pressure, but also in many hypertensive patients with normal levels of plasma renin activity. ACE inhibitors are used in a wide range of chronic illnesses such as atherosclerosis, hypertension, myocardial infarction, heart failure, diabetic complications, and stroke. To date, more than ninety controlled clinical trials evaluating the beneficial effects of 14 different ACE inhibitors were conducted. Moreover, data from experimental studies showed that ACE inhibitors can attenuate the development of atherosclerosis, oxidative stress, and vascular inflammation in a wide range of species indicating that ACE inhibition also favourably affects the vasculature. More than fifteen years ago, the bi-sulfydryl ACE-inhibitor zofenopril has shown an excellent clinical safety and efficacy in patients with hypertension and in those with myocardial infarction. More recently, this compound exhibited a potent antioxidant and antiatherosclerotic effect indicating a clinical useful vasoprotective action.

ангиотензин-превращающего ферментзофеноприлатеросклерозострый инфаркт миокарда

ACEzofenoprilatherosclerosisacute myocardial infarction

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The authors declare that there are no conflicts of interest present.