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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1728-8800-2013-3-68-71</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-198</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МНЕНИЕ ПО ПРОБЛЕМЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OPINION ON A PROBLEM</subject></subj-group></article-categories><title-group><article-title>КОМБИНИРОВАННАЯ АНТИГИПЕРТЕНЗИВНАЯ ТЕРАПИЯ: КОГДА ЦЕЛОЕ БОЛЬШЕ СУММЫ</article-title><trans-title-group xml:lang="en"><trans-title>COMBINATION ANTIHYPERTENSIVE THERAPY: WHEN THE WHOLE IS GREATER THAN THE SUM OF ITS PARTS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Таратухин</surname><given-names>Е. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Taratukhin</surname><given-names>E. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кардиолог, к. м.н., ассистент кафедры госпитальной терапии № 1 лечебного факультета</p><p>Тел.: +7 916 637 29 78 </p></bio><bio xml:lang="en"><p>tel.: +7 916 637 29 78</p></bio><email xlink:type="simple">cardio03@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Теплова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Teplova</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м.н., кардиолог, доцент кафедры</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБОУ ВПО Российский национальный исследовательский медицинский университет им. Н. И. Пирогова Минздрава России, Москва</institution></aff><aff xml:lang="en"><institution>N. I. Pirogov Russian National Medical Research University, Moscow</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>20</day><month>06</month><year>2013</year></pub-date><volume>12</volume><issue>3</issue><fpage>68</fpage><lpage>71</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Таратухин Е.О., Теплова Н.В., 2013</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="ru">Таратухин Е.О., Теплова Н.В.</copyright-holder><copyright-holder xml:lang="en">Taratukhin E.O., Teplova N.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/198">https://cardiovascular.elpub.ru/jour/article/view/198</self-uri><abstract><p>В статье поднимается вопрос об увеличении приверженности пациентов лечению при необходимости длительной или пожизненной терапии. Это осуществимо при применении комбинированных лекарственных препаратов, среди которых важна комбинация антагониста кальциевых каналов и ингибитора ангиотензин-превращающего фермента. Помимо более высокой комплаентности пациентов, комбинация позволяет пользоваться дополнительными метаболическими преимуществами, которыми обладают оба входящие в состав лекарственные средства. </p></abstract><trans-abstract xml:lang="en"><p>The paper discusses the importance of high treatment compliance in the case of long-term or life-long therapy. This problem can be resolved by the use of combination pharmacological treatment, such as the combination of a calcium channel blocker and an ACE inhibitor. Apart from the higher treatment compliance, this combination provides additional metabolic benefits, due to the beneficial metabolic effects of its components. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>ингибитор ангиотензин-превращающего фермента</kwd><kwd>блокатор кальциевых каналов</kwd><kwd>противовоспалительный</kwd><kwd>антиатеросклеротический</kwd><kwd>нефропротективный эффекты</kwd><kwd>инсулинорезистентность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ACE inhibitor</kwd><kwd>calcium channel blocker</kwd><kwd>anti-inflammatory</kwd><kwd>anti-atherosclerotic</kwd><kwd>and nephroprotective effects</kwd><kwd>insulin resistance</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Hoyer J. Non-pharmacological and pharmacological treatment of arterial hypertension: current situation. 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