cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2011-6-124-132cardiovascular-1981Research ArticleОБЗОРЫREVIEWSРастительные стерины и станолы как пищевые факторы, снижающие гиперхолестеринемию путем ингибирования всасывания холестерина в кишечникеPlant sterols and stanols as dietary factors reducing hypercholesterolemia by inhibiting intestinal cholesterol absorptionХучиеваМ. А.KhuchievaM. A.

м.н.с. отдела вторичной профилактики ХНИЗ

Москва, Тел.: (915) 209-33-10

mad2997@yandex.ruПероваН. В.PerovaN. V.

в.н.с. отдела изучения биохимических маркеров риска ХНИЗ

Москва

АхмеджановН. М.AkhmedzhanovN. M.

в.н.с. отдела вторичной профилактики ХНИЗ

Москва

ФГУ Государственный научно-исследовательский центр профилактической медицины Минздравсоцразвития РоссииРоссияState Research Centre for Preventive MedicineRussian Federation201120122011106124132Copyright © Хучиева М.А., Перова Н.В., Ахмеджанов Н.М., 20112011Хучиева М.А., Перова Н.В., Ахмеджанов Н.М.Khuchieva M.A., Perova N.V., Akhmedzhanov N.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/1981

Обзор посвящен механизму действия, гиполипидемической активности, структурной характеристике и безопасности применения растительных стеринов и станолов. Фитостерины и фитостанолы ингибируют всасывание холестерина (ХС) в кишечнике, тем самым снижают его уровень в плазме крови. Особое внимание уделено проспективным эпидемиологическим исследованиям, в которых на репрезентативной выборке показано, что концентрация фитостеринов и фитостанолов в плазме крови у пациентов с ишемической болезнью сердца (ИБС) была значительно ниже по сравнению с лицами без этого заболевания. При оценке относительного риска было обнаружено, что двукратное увеличение концентрации ситостерина в сыворотке крови связано со снижением риска ИБС на 22 %. Показано, что эфиры растительных стеринов и станолов могут рассматриваться как эффективные и безопасные ингредиенты, обогащение пищи которыми снижает уровень ХС в крови — одного из основных факторов риска сердечнососудистых заболеваний.

The review is focussed on the mechanisms of action, lipid-lowering activity, structural characteristics, and safety of plant sterins and stanols. Phytosterins and phytostanols inhibit intestinal cholesterol (CH) absorption, therefore decreasing plasma CH levels. The emphasis is put on prospective epidemiological studies of representative samples, which demonstrated that plasma concentrations of phytosterins and phytostanols in patients with coronary heart disease (CHD) are substantially lower than in CHD-free participants. A two-fold increase in serum sytosterin concentration was associated with a reduction in relative risk of CHD by 22 %. Plant sterin and sterol esters could be regarded as effective and safe dietary ingredients decreasing blood levels of CH — one of the major cardiovascular disease risk factors.

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The authors declare that there are no conflicts of interest present.