cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLCcardiovascular-1988Research ArticleАРТЕРИАЛЬНАЯ ГИПЕРТОНИЯARTERIAL HYPERTENSIONСравнительная эффективность периндоприла и эналаприла у пациентов с артериальной гипертензией и ожирениемComparative effectiveness of perindopril and enalapril in patients with arterial hypertension and obesityНедогодаС. В.NedogodaS. V.

зав. кафедрой терапии и эндокринологии ФУВ

Волгоград

Volgograd

nedogodasv@rambler.ruЛедяеваА. А.LedyaevaA. A.

аспирант кафедры

Волгоград

Volgograd

ЧумачокЕ. В.ChumachokE. V.

аспирант кафедры

Волгоград

Volgograd

ЦомаВ. В.TsomaV. V.

ассистент кафедры

Волгоград

Volgograd

МазинаГ. Г.MazinaG. G.

аспирант кафедры

Волгоград

Volgograd

СаласюкА. С.SalasyukA. S.

аспирант кафедры

Волгоград

Volgograd

БарыкинаИ. Н.BarykinaI. N.

ассистент кафедры

Волгоград

Volgograd

Волгоградский государственный медицинский университетVolgograd State Medical University2011010119701071017Copyright © Недогода С.В., Ледяева А.А., Чумачок Е.В., Цома В.В., Мазина Г.Г., Саласюк А.С., Барыкина И.Н., 19701970Недогода С.В., Ледяева А.А., Чумачок Е.В., Цома В.В., Мазина Г.Г., Саласюк А.С., Барыкина И.Н.Nedogoda S.V., Ledyaeva A.A., Chumachok E.V., Tsoma V.V., Mazina G.G., Salasyuk A.S., Barykina I.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/1988

Цель. Оценка антигипертензивной эффективности и влияния на метаболические показатели периндоприла и эналаприла у больных артериальной гипертензией (АГ) и ожирением (Ож). Материал и методы. В слепое, рандомизированное, контролируемое, сравнительное исследование в параллельных группах (периндоприл vs эналаприла на протяжении 24 нед.) были включены 60 больных АГ и Ож. Результаты. Выявлены достоверные различия в пользу периндоприла по антигипертензивной эффективности, кардио-, ангио-, нефропротекции и способности улучшать показатели липидного, углеводного и пуринового обменов. Только периндоприл уменьшает проявления инсулинорезистетности, гиперлептинемии и воспаления у пациентов с АГ и Ож. Терапия периндоприлом в отличие от эналаприла оказывает выраженное положительное влияние на антропометрические показатели и размер жировых отложений. Заключение. При сочетании АГ и Ож периндоприл имеет преимущества перед эналаприлом по своей антигипертензивной эффективности, органопротекции и влиянию на ключевые гуморальные факторы, влияющие на рост массы тела и повышение АД.

Aim. To assess the antihypertensive effectiveness of perindopril and enalapril, as well as their effects on metabolic parameters, in patients with arterial hypertension (AH) and obesity (O). Material and methods. This blind, randomized, controlled, parallel comparative study included 60 patients with AH and O, who were administered perindopril or enalapril for 24 weeks. Results. Perindopril demonstrated significantly better antihypertensive effectiveness, cardio-, angio-, and nephroprotection, as well as an improvement in lipid, carbohydrate, and purine metabolism parameters. In patients with AH and O, only perindopril had beneficial effects on insulin resistance, hyperleptinemia, and inflammation. In contrast to enalapril treatment, perindopril therapy was associated with a marked improvement in anthropometry parameters and a reduction in fat tissue deposits. Conclusion. In patients with a combination of AH and O, perindopril was superior to enalapril in terms of antihypertensive effectiveness, organ protection, and the effects on key humoral factors determining body mass increase and blood pressure elevation.

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The authors declare that there are no conflicts of interest present.