cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2013-3-72-77cardiovascular-199Research ArticleОБЗОРЫREVIEWSМЕХАНИЗМЫ КОМБИНИРОВАННОГО ДЕЙСТВИЯ ИНГИБИТОРОВ АНГИОТЕНЗИН-ПРЕВРАЩАЮЩЕГО ФЕРМЕНТА И АНТАГОНИСТОВ КАЛЬЦИЯ ПРИ АРТЕРИАЛЬНОЙ ГИПЕРТОНИИMECHANISMS OF COMBINED ACTION OF ACE INHIBITORS AND CALCIUM ANTAGONISTS IN ARTERIAL HYPERTENSIONАсташкинЕ. И.AstashkinE. I.

профессор кафедры патологии

Тел.: (916) 062–05–30 

287ast@mail.ruГлезерМ. Г.GlezerM. G.

профессор кафедры профилактической и неотложной кардиологии

Первый Московский государственный медицинский университет им. И. М. Сеченова, МоскваI. M. Sechenov First Moscow State Medical University, Moscow2013200620131237277Copyright © Асташкин Е.И., Глезер М.Г., 20132013Асташкин Е.И., Глезер М.Г.Astashkin E.I., Glezer M.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/199

В обзоре рассмотрены представления об эффективности применения водорастворимых ингибиторов ангиотензин-превращающего фермента (ИАПФ) и антагонистов кальция (АК) при их монотерапии или терапии с помощью фиксированных комбинаций для лечения артериальной гипертензии (АГ). Обсуждаются результаты рентгеноструктурного анализа кристаллов комплексов лизиноприла с АПФ, свидетельствующие о высокой избирательности и эффективности ингибиторного действия лизиноприла на разные формы АПФ гормональной ренин-ангиотензин-альдостероновой системы и тканевые поверхностные ренин-ангиотензиновой системы. Анализируется связь между особенностями действия АК III поколения амлодипина, его эффектами при АГ. Рассматриваются преимущества препарата Экватор, являющегося фиксированной комбинацией амлодипина (5 мг) и лизиноприла (10 мг), которые оказывают взаимодополняющие защитные эффекты при АГ. 

This review presents the modern views on the effectiveness of water-soluble angiotensin-converting enzyme (ACE) antagonists and calcium antagonists (CA), as monotherapy or as fixed-dose combination therapy, in the treatment of arterial hypertension (AH). The results of the X-ray structural analysis of crystal ACE-lisinopril complexes suggest a highly selective, strong inhibitory effect of lisinopril on various ACE forms of the hormonal renin-angiotensin-aldosterone system and tissue renin-angiotensin systems. The association between specific action mechanisms and therapeutic effects in hypertension is analysed for a third-generation CA amlodipine. The benefits of a fixed-dose combination medication Ekvator (amlodipine 5 mg plus lisinopril 10 mg) in hypertension are described, including its synergetic protective effects. 

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The authors declare that there are no conflicts of interest present.