cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLCcardiovascular-2053Research ArticleОБЗОРЫREVIEWSПрименение статинов в клинической практикеStatins in clinical practiceСивковА. С.SivkovA. S.

доцент кафедры клинической фармакологии и пропедевтики внутренних болезней

elmed@yandex.ruПауковС. В.PaukovS. V.

заведующий 3 терапевтическим отделением

КукесВ. Г.KukesV. G.

заведующий кафедрой клинической фармакологии и пропедевтики внутренних болезней

СивковС. И.SivkovS. I.

доцент кафедры клинической фармакологии и пропедевтики внутренних болезней

Московская медицинская академия им. И.М.СеченоваI.M. Sechenov Moscow Medical AcademyГородская клиническая больница № 23 им. “Медсантруд” г. Москвы. МоскваMoscow City Clinical Hospital No. 23. Moscow20102004201092100107Copyright © Сивков А.С., Пауков С.В., Кукес В.Г., Сивков С.И., 20102010Сивков А.С., Пауков С.В., Кукес В.Г., Сивков С.И.Sivkov A.S., Paukov S.V., Kukes V.G., Sivkov S.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/2053

В обзоре обсуждаются вопросы применения статинов у больных ишемической болезни сердца (ИБС), в т.ч. с острым коронарным синдромом (ОКС) с позиций результатов, представленных в последних исследованиях. Даны современные представления о механизмах действия гиполипидемических препаратов из группы статинов, в т.ч. их плейотропные эффекты, имеющие положительное значение для лечения ИБС, включая ОКС. Особого внимания в обсуждении препаратов из группы статинов заслуживает аторвастатин - один из наиболее эффективных и безопасных препаратов.

This review discusses statin treatment in patients with coronary heart disease (CHD), including acute coronary syndrome (ACS), based on the results of the latest clinical trials. The modern views on statin mechanisms of action are presented, including their pleiotropic effects, important for CHD and ACS treatment. Currently, the most effective and safe statin is atorvastatin.

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The authors declare that there are no conflicts of interest present.