cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2013-4-16-20cardiovascular-207Research ArticleКОРОНАРНАЯ БОЛЕЗНЬ СЕРДЦАCORONARY HEART DISEASEСУБФРАКЦИОННЫЙ СПЕКТР ЛИПОПРОТЕИНОВ НИЗКИХ ПЛОТНОСТЕЙ ПРИ РАЗНОЙ СТЕПЕНИ СТЕНОЗОВ КОРОНАРНЫХ АРТЕРИЙLOW-DENSITY LIPOPROTEIN SUBFRACTIONS AND VARYING DEGREE OF CORONARY STENOSISОзероваИ. Н.OzerovaI. N.

к. б.н, в. н.с. отдела изучения биохимических маркеров риска ХНИЗ

Тел.: (495) 627-03-49, 8 (619) 089-19-49 

iozerova@gnicpm.ruПероваН. В.PerovaN. V.

д. м.н., проф., в. н.с.отдела

МетельскаяВ. А.MetelskayaV. A.

д. б.н., проф., руководитель отдела

ЧернушевичО. И.ChernushevichO. I.

м. н.с. отдела

ГавриловаН. Е.GavrilovaN. E.

к. м.н., с. н.с. отдела клинической кардиологии и молекулярной генетики

ФГБУ “Государственный научно-исследовательский центр профилактической медицины” Минздрава России, МоскваState Research Centre for Preventive Medicine, Moscow2013200820131241620Copyright © Озерова И.Н., Перова Н.В., Метельская В.А., Чернушевич О.И., Гаврилова Н.Е., 20132013Озерова И.Н., Перова Н.В., Метельская В.А., Чернушевич О.И., Гаврилова Н.Е.Ozerova I.N., Perova N.V., Metelskaya V.A., Chernushevich O.I., Gavrilova N.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/207Цель

Цель. Выяснить, сопряжены ли особенности субфракционного спектра фракций липопротеинов промежуточной и низкой плотности (ЛПП и ЛНП) крови со степенью (ст.) выраженности ангиографически документированного коронарного атеросклероза и связаны ли эти изменения с другими биохимическими факторами риска коронарной болезни сердца (КБС), в первую очередь, с гипертриглицеридемией (ГТГ).

Материал и методы

Материал и методы. В исследование включены 129 пациентов 33–75 лет (76 мужчин и 53 женщины), которым по показаниям была проведена коронароангиография. По выраженности поражения коронарных артерий (КА) пациенты разделены на три группы (гр.) со ст. стеноза 0–20%, 21–70% и >70%. Субфракционный спектр ЛПП и ЛНП был определен при использовании “Липопринт ЛНП системы”, включающей электрофорез в 3% полиакриламидном геле.

Результаты

Результаты. Гр. пациентов не различались по уровню липидных и апобелковых показателей, а концентрации высокочувствительного С-реактивного белка и глюкозы, а также индекс инсулинорезистентности (HOMA-IR) оказались выше у пациентов 3 гр. При этом в большем количестве случаев при высокой ст. поражения КА обнаружены мелкие плотные частицы ЛНП. Более высокое содержание мелких плотных частиц ЛНП3 выявлено при ГТГ только при стенозе КА ≥21–70%.

Заключение

Заключение. Полученные данные по субфракционному спектру липопротеинов у пациентов с документированным коронарным атеро- склерозом позволили выявить связь более атерогенных мелких плотных частиц ЛНП3 со ст. выраженности поражения КА и уровнем в крови ТГ. Сочетание ГТГ со значительным количеством ЛНП3 может рассма- триваться как дополнительный маркер высокой ст. поражения КА.

Aim

Aim. To investigate whether low and intermediate density lipoprotein (LDL, IDL) subfractions are associated with a degree of angiographically verified coronary atherosclerosis, as well as with other biochemical risk factors of coronary heart disease (CHD), and hypertriglyceridemia (HTG) in particular.

Material and methods

Material and methods. The study included 129 patients (76 men and 53 women), aged 33–75 years, who were referred for coronary angiography. All participants were divided into three groups by the degree of coronary artery (CA) stenosis: 0–20%, 21–70%, and >70%. LDL and IDL subfractions were measured with the Lipoprint LDL System (electrophoresis in 3% polyacrylamide gel).

Results

Results. All groups were similar by the levels of lipid and apoprotein parameters. The levels of high-sensitive C-reactive protein and glucose, as well as HOMA-IR index, were higher in Group 3 patients. In most cases of severe CA stenosis, small dense LDL particles were detected. In HTG patients, higher levels of small dense LDL3 particles were registered only together with the CA stenosis of at least 21–70%.

Conclusion

Conclusion. The findings on lipoprotein subfractions, obtained with the Lipoprint LDL System, have demonstrated that in patients with verified coronary atherosclerosis, there is a link between the levels of more atherogenic small dense LDL3 particles, the degree of CA stenosis, and blood TG levels. The combination of HTG and high LDL3 levels could be considered an additional marker of severe CA atherosclerosis. 

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The authors declare that there are no conflicts of interest present.