cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLCcardiovascular-2094Research ArticleМНЕНИЕ ПО ПРОБЛЕМЕOPINION ON A PROBLEMВзаимодействие альтернативной терапии с варфарином: что необходимо знать врачамAlternative therapy interaction with warfarin: what doctors should knowКозловаТ. В.KozlovaT. B.

доцент кафедры госпитальной терапии № 1

dockozlova@gmail.comТаратутаТ. В.TaratutaT. V.

ассистент кафедры общей врачебной практики

АксеноваМ. Б.AksenovaM. B.

доцент кафедры госпитальной терапии № 1

ХлевчукТ. В.KhlevchukT. V.

доцент кафедры госпитальной терапии № 1

Московская медицинская академия им. И. М. Сеченова. МоскваРоссияI.M. Sechenov Moscow Medical Academy. MoscowRussian Federation20102006201093106110Copyright © Козлова Т.В., Таратута Т.В., Аксенова М.Б., Хлевчук Т.В., 20102010Козлова Т.В., Таратута Т.В., Аксенова М.Б., Хлевчук Т.В.Kozlova T.B., Taratuta T.V., Aksenova M.B., Khlevchuk T.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/2094

Варфарин представляет собой лекарственный препарат, на эффективность и безопасность которого значительно влияет сопутствующая терапия. В статье рассмотрены основные механизмы лекарственного взаимодействия с варфарином, лежащие в основе нежелательных реакций: нарушение функции тромбоцитов, повреждение желудочно-кишечного тракта, подавление синтеза витамина К в кишечнике, нарушение метаболизма варфарина, вмешательство в цикл витамина К. Выделены основные группы препаратов, которые воздействуют на варфарин. В статье отмечено разнонаправленное влияние пищевых продуктов, биологически активных добавок, растительных препаратов на гипокоагулянтный эффект варфарина.

Warfarin effectiveness and safety is substantially affected by concurrent therapy. This paper reviews the main mechanisms of warfarin interactions with other agents, which underlie adverse effect development: platelet dysfunction, gastro-intestinal effects, suppressed intestinal synthesis of vitamin K, disturbed warfarin metabolism, or disrupted vitamin K cycle. The main medication groups, affecting warfarin effectiveness and safety, are presented. The effects of foods, supplements, and herbal medications on anticoagulant effect of warfarin are discussed.

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The authors declare that there are no conflicts of interest present.