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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-2151</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МНЕНИЕ ПО ПРОБЛЕМЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OPINION ON A PROBLEM</subject></subj-group></article-categories><title-group><article-title>Пациенты высокого риска: современная стратегия лечения</article-title><trans-title-group xml:lang="en"><trans-title>High-risk patients: modern treatment strategy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Небиеридзе</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Nebieridze</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>руководитель отдела профилактики метаболических нарушений</p></bio><email xlink:type="simple">dneberidze@gnicpm.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мелия</surname><given-names>А.</given-names></name><name name-style="western" xml:lang="en"><surname>Meliya</surname><given-names>A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Государственный научно-исследовательский центр профилактической медицины Росмедтехнологии. Москва</institution></aff><aff xml:lang="en"><institution>State Research Centre for Preventive Medicine. Moscow</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Кардиологическая клиника “Гули”. Тбилиси</institution></aff><aff xml:lang="en"><institution>Cardiology Clinic “Guli”. Tbilisi</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>20</day><month>12</month><year>2010</year></pub-date><volume>9</volume><issue>6</issue><fpage>97</fpage><lpage>101</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Небиеридзе Д.В., Мелия А., 2010</copyright-statement><copyright-year>2010</copyright-year><copyright-holder xml:lang="ru">Небиеридзе Д.В., Мелия А.</copyright-holder><copyright-holder xml:lang="en">Nebieridze D.V., Meliya A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/2151">https://cardiovascular.elpub.ru/jour/article/view/2151</self-uri><abstract><p>В обзоре анализируются современные представления о пациентах высокого сердечно-сосудистого риска (ССР). Пациенты высокого ССР – это лица без клинических проявлений атеросклероза. Актуальность стратегии лечения определяется тем, что пациентов высокого ССР в общей массе кардиологических больных подавляющее большинство, и основная доля осложнений приходится на эту группу. Своевременное выявление пациентов с высоким ССР и правильная стратегия их ведения могут существенно снизить частоту осложнений. Современная стратегия ведения пациентов высокого ССР требует усиления медикаментозного лечения. Принцип ведения пациентов высокого ССР такой же, как и больных, которые уже имеют ССЗ. Детально обсуждаются такие компоненты медикаментозного лечения, как антигипертензивная, липид-снижающая и антиагрегантная терапия.</p></abstract><trans-abstract xml:lang="en"><p>This review summarizes modern views on high-risk patients as atherosclerosis-free individuals. The importance of high-risk approach is explained by the fact that this group encompasses the majority of cardiac patients, as well as the majority of cardiovascular events. Therefore, early diagnostics and adequate management of high-risk patients could substantially reduce the incidence of cardiovascular events. The modern treatment strategy for high-risk patients requires pharmaceutical intervention, and has the same principles as the treatment of patients with diagnosed cardiovascular disease. Such components of pharmaceutical treatment as antihypertensive, lipidlowering, and anti-aggregant therapy are discussed in detail.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>пациенты высокого риска</kwd><kwd>антигипертензивная терапия</kwd><kwd>липид-снижающая терапия</kwd><kwd>антиагрегантная терапия</kwd><kwd>Аспирин®Кардио</kwd></kwd-group><kwd-group xml:lang="en"><kwd>high-risk patients</kwd><kwd>antihypertensive therapy</kwd><kwd>lipid-lowering therapy</kwd><kwd>anti-aggregant therapy</kwd><kwd>Aspirin® Cardio</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">European guidelines on cardiovascular disease prevention in clinical practice: executive summary: Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice // European Journal of Cardiovascular Prevention &amp; Rehabilitation: September 2007 - Volume 14 - Issue – PP E1-E40.</mixed-citation><mixed-citation xml:lang="en">European guidelines on cardiovascular disease prevention in clinical practice: executive summary: Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice // European Journal of Cardiovascular Prevention &amp; Rehabilitation: September 2007 - Volume 14 - Issue – PP E1-E40.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Третий пересмотр рекомендаций ВНОК и РМОАГ по диагностике и лечению артериальной гипертензии. Кардиоваск тер профил 2008; 4 (3) ч.1: 105-20.</mixed-citation><mixed-citation xml:lang="en">Третий пересмотр рекомендаций ВНОК и РМОАГ по диагностике и лечению артериальной гипертензии. Кардиоваск тер профил 2008; 4 (3) ч.1: 105-20.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Sever PS, Dahlöf B, Poulter NR et al. Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial—Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial. //The Lancet, Volume 361, Issue 9364, Pages 1149 - 1158, 5 April 2003.</mixed-citation><mixed-citation xml:lang="en">Sever PS, Dahlöf B, Poulter NR et al. Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial—Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial. //The Lancet, Volume 361, Issue 9364, Pages 1149 - 1158, 5 April 2003.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Brugts J.J, Yetgin T., Hoeks S.E., Gotto A.M., et al. The benefits of statins in people without established cardiovascular disease but with cardiovascular risk factors: meta-analysis of randomised controlled trials. // BMJ 2009;338:b2376.</mixed-citation><mixed-citation xml:lang="en">Brugts J.J, Yetgin T., Hoeks S.E., Gotto A.M., et al. The benefits of statins in people without established cardiovascular disease but with cardiovascular risk factors: meta-analysis of randomised controlled trials. // BMJ 2009;338:b2376.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Jaszewsky R. Frequency of gastroduodenal lesions in asymptomatic patients on chronic aspirin or nonsteroidal anti-inflammatory drug therapy. J Clin Gastroenterol 1990; 12: 10-3.</mixed-citation><mixed-citation xml:lang="en">Jaszewsky R. Frequency of gastroduodenal lesions in asymptomatic patients on chronic aspirin or nonsteroidal anti-inflammatory drug therapy. J Clin Gastroenterol 1990; 12: 10-3.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Walker J, Robinson J, Stewart J, et al. Does enteric-coated aspirin result in a lower incidence of gastrointestinal complications compared to normal aspirin? Interact Cardiovasc Thorac Surg 2007; 6(4): 519-22.</mixed-citation><mixed-citation xml:lang="en">Walker J, Robinson J, Stewart J, et al. Does enteric-coated aspirin result in a lower incidence of gastrointestinal complications compared to normal aspirin? Interact Cardiovasc Thorac Surg 2007; 6(4): 519-22.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Dietz R, Rauch B. Leitlinie zur Diagnose und Behandlung der chronischen koronaren Herzerkrankung der Deutschen Gesellschaft fr Kardiologie – Herz- und Kreislaufforschung (DGK). Z Kardiol 2003; 92: 501-21.</mixed-citation><mixed-citation xml:lang="en">Dietz R, Rauch B. Leitlinie zur Diagnose und Behandlung der chronischen koronaren Herzerkrankung der Deutschen Gesellschaft fr Kardiologie – Herz- und Kreislaufforschung (DGK). Z Kardiol 2003; 92: 501-21.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Collaborative Group of the Primary Prevention Project. Lowdose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general practice. Lancet 2001; 357: 89-95.</mixed-citation><mixed-citation xml:lang="en">Collaborative Group of the Primary Prevention Project. Lowdose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general practice. Lancet 2001; 357: 89-95.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
