cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLCcardiovascular-2166Research ArticleМНЕНИЕ ПО ПРОБЛЕМЕOPINION ON A PROBLEMЯвляется ли эректильная дисфункция маркером сердечнососудистых заболеваний, обусловленных атеросклерозом?Could erectile dysfunction be a marker of atherosclerotic cardiovascular disease?ШарвадзеГ. Г.SharvadzeG. G.

врач уролог

giga@bk.ruМамедовМ. Н.MamedovM. N.

руководитель лаборатории оценки и коррекции сердечно-сосудистого риска

ПоддубскаяЕ. А.PoddubskayaE. A.

с.н.с. лаборатории оценки и коррекции сердечно-сосудистого риска

КурбатовД. Г.KurbatovD. G.

заведующий отделением андрологии и урологии

Городская поликлиника № 124Moscow City Polyclinic No. 124Государственный научно-исследовательский центр профилактической медицины РосмедтехнологииState Research Centre for Preventive MedicineФГУ Эндокринологический научный центр. МоскваEndocrinology Research Centre. Moscow201001011970977985Copyright © Шарвадзе Г.Г., Мамедов М.Н., Поддубская Е.А., Курбатов Д.Г., 19701970Шарвадзе Г.Г., Мамедов М.Н., Поддубская Е.А., Курбатов Д.Г.Sharvadze G.G., Mamedov M.N., Poddubskaya E.A., Kurbatov D.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/2166

Статья посвящена эректильной дисфункции (ЭД), которая рассматривается, как междисциплинарная проблема. Приводится подробный обзор результатов клинических исследований, мета-анализов доказывающих наличие причинно-следственной связи ЭД с такими заболеваниями как ИБС, артериальная гипертензия (АГ), дислипидемия (ДЛП), сахарный диабет (СД). Наряду с оценкой роли общих факторов риска (ФР) сердечно-сосудистых заболеваний (ССЗ) в развитии ЭД, показан общий патогенетический механизм возникновения этих заболеваний, в основе которых лежит эндотелиальная дисфункция (ЭД). Отражены распространенность ЭД и андроген дефицитного состояния, и их связь с метаболическим синдромом (МС). ЭД можно рассматривать как предиктор развития ССЗ, и что раннее выявление общих ФР развития ССЗ и ЭД можно использовать для прогноза и формирования групп больных высокого риска по обоим заболеваниям. Учитывая, что метаболические ФР выступают в качестве объединяющего звена между ССЗ, ЭД и андроген-дефицитным состоянием, дальнейшее изучение этой проблемы поможет внести существенный вклад в формирование более эффективных подходов к лечению и профилактике этих заболеваний.

The paper is focused on erectile dysfunction (ED) as an inter-disciplinary problem. The detailed analysis of relevant clinical trials and meta-analyses is performed, demonstrating a causal relationship between ED and coronary heart disease, arterial hypertension, dyslipidemias, and diabetes mellitus. The role of common cardiovascular (CVD) risk factors (RFs) in ED development, as well as a shared, endothelial dysfunction-related pathogenetic mechanism of CVD, is discussed. The prevalence of ED and androgen deficiency, together with their link to metabolic syndrome (MS), is presented. It is shown that ED could be regarded as CVD predictor, and that early diagnostics of the RFs common for CVD and ED can be used for risk prediction and identification of highrisk groups. Since metabolic RFs are common for CVD, ED, and androgen deficiency, further research in this area may facilitate more efficient approaches to prevention and treatment of these diseases.

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The authors declare that there are no conflicts of interest present.