cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLCcardiovascular-2170Research ArticleОБЗОРЫREVIEWSЭтиологические и патогенетические факторы первичной артериальной гипертонииAetiological and pathogenetic factors of primary arterial hypertensionВолковВ. С.VolkovV. S.

зав.кафедрой госпитальной терапии

gzyrina@yandex.ruТофилоА. П.TofiloA. P.

доцент кафедры усовершенствования врачей

ГОУ ВПО Тверская государcтвенная медицинская академия Росздрава. ТверьTver State Medical Academy. Tver20100101197097105111Copyright © Волков В.С., Тофило А.П., 19701970Волков В.С., Тофило А.П.Volkov V.S., Tofilo A.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/2170

В последние десятилетия накопилось достаточно данных, свидетельствующих, что артериальная гипертония (АГ) является полигенно наследуемой патологией. При этом недостаточная экскреция почками поваренной соли (ПС), генетически обусловленная или приобретенная (болезни, старение, ожирение и др.), является центральным механизмом патогенеза АГ. Развитие АГ необходимо рассматривать как компенсаторную реакцию, направленную на увеличение экскреции почками ПС и нормализацию объема гомеостаза и циркулирующей крови.

Over the last few decades, vast evidence has emerged, confirming polygenic hereditary nature of arterial hypertension (AH). Reduced renal salt excretion, genetic or acquired due to diseases, ageing, obesity, or other factors, is a key mechanism in AH pathogenesis. AH development should be regarded as a compensatory reaction, aimed at increasing renal salt excretion, normalising circulating blood volume, and maintaining homeostasis.

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The authors declare that there are no conflicts of interest present.