<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-2183</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МНЕНИЕ ПО ПРОБЛЕМЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OPINION ON A PROBLEM</subject></subj-group></article-categories><title-group><article-title>Пролапс митрального клапана: “много шума из ничего” или реальная и нерешенная проблема?</article-title><trans-title-group xml:lang="en"><trans-title>Mitral valve prolapse: «Much Ado About Nothing», or a real unsolved problem?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Земцовский</surname><given-names>Э. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zemtsovsky</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>1 заведующий лабораторией соединительно-тканных дисплазий, 2 заведующий кафедрой пропедевтики внутренних болезней</p></bio><email xlink:type="simple">zemtsovsky@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Малев</surname><given-names>Э. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Malev</surname><given-names>E. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>заведующий лабораторией ультразвуковых методов исследования, ведущий научный сотрудник лаборатории соединительно-тканных дисплазий</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Реева</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Reeva</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>1 старший научный сотрудник лаборатории соединительно-тканных дисплазий, 2 доцент кафедры пропедевтики внутренних болезней</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральный центр сердца, крови и эндокринологии им. В.А. Алмазова;&#13;
Cанкт-Петербургская государственная педиатрическая медицинская академия. Санкт-Петербург</institution></aff><aff xml:lang="en"><institution>V.A. Almazov Federal Centre of Heart, Blood, and Endocrinology;&#13;
St. Petersburg State Pediatrics Medical Academy. St. Petersburg</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Федеральный центр сердца, крови и эндокринологии им. В.А. Алмазова</institution></aff><aff xml:lang="en"><institution>V.A. Almazov Federal Centre of Heart, Blood, and Endocrinology</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>01</day><month>01</month><year>1970</year></pub-date><volume>9</volume><issue>8</issue><fpage>69</fpage><lpage>74</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Земцовский Э.В., Малев Э.Г., Реева С.В., 1970</copyright-statement><copyright-year>1970</copyright-year><copyright-holder xml:lang="ru">Земцовский Э.В., Малев Э.Г., Реева С.В.</copyright-holder><copyright-holder xml:lang="en">Zemtsovsky E.V., Malev E.G., Reeva S.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/2183">https://cardiovascular.elpub.ru/jour/article/view/2183</self-uri><abstract><p>Представлено современное состояние проблемы пролапса митрального клапана (ПМК). Рассмотрены спорные и нерешенные вопросы терминологии для ПМК на основе разработанных и согласованных рекомендаций по проблеме, характеристики различных вариантов ПМК. Приводятся современные эхокардиографические (ЭхоКГ) критерии диагностики ПМК, оценивается распространенность ПМК при использовании этих диагностических критериев, сравниваются результаты Фремингемского исследования и собственные данные. Оценивается взаимосвязь вегетативной дисфункции и ПМК. Сравниваются различные подходы к стратификации риска на основе ЭхоКГ и клинических данных. Описываются современные методы лечения и тактика ведения лиц с ПМК.</p></abstract><trans-abstract xml:lang="en"><p>The paper discusses the modern state of the mitral valve prolapse (MVP) problem. Controversial and unresolved issues on terminology, diagnostics, and tactics for different MVP variants are considered on the basis of the “Heritable disorders of connective tissue” recommendations (2009) by Expert Committee, the Society of Cardiology of the Russian Federation (VNOK). The modern diagnostic criteria of MVP are discussed, as well as echocardiography-estimated MVP prevalence while using those diagnostic criteria, and the comparison of Framingham Heart Study results to the authors’ own data. The interrelation between autonomic dysfunction and MVP is assessed, and different approaches to the stratification of MVP complication risk are compared, based on the echocardiography results and clinical data. The modern methods of MVP treatment and management strategy are also described.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>пролапс митрального клапана</kwd><kwd>наследственные нарушения соединительной ткани</kwd><kwd>дисплазия соединительной ткани</kwd><kwd>вегетативная дисфункция</kwd><kwd>стратификация риска</kwd></kwd-group><kwd-group xml:lang="en"><kwd>mitral valve prolapse</kwd><kwd>inherited connective tissue disorders</kwd><kwd>connective tissue dysplasia</kwd><kwd>autonomic dysfunction</kwd><kwd>risk stratification</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. JACC 2006; 48(3): e1-148.</mixed-citation><mixed-citation xml:lang="en">ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. JACC 2006; 48(3): e1-148.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Devereux RB, Kramer-Fox R, Kligfield P. Mitral valve prolapse: causes, clinical manifestations, and management. Ann Intern Med 1989; 111: 305-17.</mixed-citation><mixed-citation xml:lang="en">Devereux RB, Kramer-Fox R, Kligfield P. Mitral valve prolapse: causes, clinical manifestations, and management. Ann Intern Med 1989; 111: 305-17.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Waller BF, Morrow AG, Maron BJ, et al. Etiology of clinically isolated, severe, chronic, pure mitral regurgitation: analysis of 97 patients over 30 years of age having mitral valve replacement. Am Heart J 1982; 104: 276-88.</mixed-citation><mixed-citation xml:lang="en">Waller BF, Morrow AG, Maron BJ, et al. Etiology of clinically isolated, severe, chronic, pure mitral regurgitation: analysis of 97 patients over 30 years of age having mitral valve replacement. Am Heart J 1982; 104: 276-88.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Freed LA, Levy D, Levine RA, et al. Prevalence and clinical outcome of mitral-valve prolapse. N Engl J Med 1999; 341: 1-7.</mixed-citation><mixed-citation xml:lang="en">Freed LA, Levy D, Levine RA, et al. Prevalence and clinical outcome of mitral-valve prolapse. N Engl J Med 1999; 341: 1-7.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Levine RA, Triulzi MO, Harrigan P, Weyman AE. The relationship of mitral annular shape to the diagnosis of mitral valve prolapse. Circulation 1987; 75: 756-67.</mixed-citation><mixed-citation xml:lang="en">Levine RA, Triulzi MO, Harrigan P, Weyman AE. The relationship of mitral annular shape to the diagnosis of mitral valve prolapse. Circulation 1987; 75: 756-67.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Levine RA, Handschumacher MD, Sanfilippo AJ, et al. Threedimensional echocardiographic reconstruction of the mitral valve, with implications for the diagnosis of mitral valve prolapse. Circulation 1989; 80: 589-98.</mixed-citation><mixed-citation xml:lang="en">Levine RA, Handschumacher MD, Sanfilippo AJ, et al. Threedimensional echocardiographic reconstruction of the mitral valve, with implications for the diagnosis of mitral valve prolapse. Circulation 1989; 80: 589-98.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Freed LA, Benjamin EJ, Levy D, et al. Mitral valve prolapse in the general population: the benign nature of echocardiographic features in the Framingham Heart Study. JACC 2002; 40: 1298-304.</mixed-citation><mixed-citation xml:lang="en">Freed LA, Benjamin EJ, Levy D, et al. Mitral valve prolapse in the general population: the benign nature of echocardiographic features in the Framingham Heart Study. JACC 2002; 40: 1298-304.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Allen H, Harris A, Leatham A. Significance and prognosis of an isolated late systolic murmur: a 9- to 22-year follow-up. Br Heart J 1974; 36: 525-32.</mixed-citation><mixed-citation xml:lang="en">Allen H, Harris A, Leatham A. Significance and prognosis of an isolated late systolic murmur: a 9- to 22-year follow-up. Br Heart J 1974; 36: 525-32.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Mills P, Rose J, Hollingsworth J, et al. Long-term prognosis of mitral valve prolapse. N Engl J Med 1977; 297: 13- 8.</mixed-citation><mixed-citation xml:lang="en">Mills P, Rose J, Hollingsworth J, et al. Long-term prognosis of mitral valve prolapse. N Engl J Med 1977; 297: 13- 8.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Devereux RB, Brown WT, Kramer-Fox R, Sachs I. Inheritance of mitral valve prolapse: effect of age and sex on gene expression. Ann Intern Med 1982; 97: 826-32.</mixed-citation><mixed-citation xml:lang="en">Devereux RB, Brown WT, Kramer-Fox R, Sachs I. Inheritance of mitral valve prolapse: effect of age and sex on gene expression. Ann Intern Med 1982; 97: 826-32.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Fontana ME, Sparks EA, Boudoulas H, Wooley CF. Mitral valve prolapse and the mitral valve prolapse syndrome. Curr Probl Cardiol 1991; 16: 309-75.</mixed-citation><mixed-citation xml:lang="en">Fontana ME, Sparks EA, Boudoulas H, Wooley CF. Mitral valve prolapse and the mitral valve prolapse syndrome. Curr Probl Cardiol 1991; 16: 309-75.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Clemens JD, Horwitz RI, Jaffe CC, et al. A controlled evaluation of the risk of bacterial endocarditis in persons with mitral-valve prolapse. N Engl J Med 1982; 307: 776-81.</mixed-citation><mixed-citation xml:lang="en">Clemens JD, Horwitz RI, Jaffe CC, et al. A controlled evaluation of the risk of bacterial endocarditis in persons with mitral-valve prolapse. N Engl J Med 1982; 307: 776-81.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Devereux RB, Frary CJ, Kramer-Fox R, et al. Cost-effectiveness of infective endocarditis prophylaxis for mitral valve prolapse with or without a mitral regurgitant murmur. Am J Cardiol 1994; 74: 1024-9.</mixed-citation><mixed-citation xml:lang="en">Devereux RB, Frary CJ, Kramer-Fox R, et al. Cost-effectiveness of infective endocarditis prophylaxis for mitral valve prolapse with or without a mitral regurgitant murmur. Am J Cardiol 1994; 74: 1024-9.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Wilson LA, Keeling PW, Malcolm AD, et al. Visual complications of mitral leaflet prolapse. Br Med J 1977; 2: 86-8.</mixed-citation><mixed-citation xml:lang="en">Wilson LA, Keeling PW, Malcolm AD, et al. Visual complications of mitral leaflet prolapse. Br Med J 1977; 2: 86-8.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Barnett HJ, Boughner DR, Taylor DW, et al. Further evidence relating mitral-valve prolapse to cerebral ischemic events. N Engl J Med 1980; 302: 139-44.</mixed-citation><mixed-citation xml:lang="en">Barnett HJ, Boughner DR, Taylor DW, et al. Further evidence relating mitral-valve prolapse to cerebral ischemic events. N Engl J Med 1980; 302: 139-44.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Vohra J, Sathe S, Warren R, et al. Malignant ventricular arrhythmias in patients with mitral valve prolapse and mild mitral regurgitation. Pacing Clin Electrophysiol 1993; 16: 387-93.</mixed-citation><mixed-citation xml:lang="en">Vohra J, Sathe S, Warren R, et al. Malignant ventricular arrhythmias in patients with mitral valve prolapse and mild mitral regurgitation. Pacing Clin Electrophysiol 1993; 16: 387-93.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Chandraratna PA, Nimalasuriya A, Kawanishi D, et al. Identification of the increased frequency of cardiovascular abnormalities associated with mitral valve prolapse by twodimensional echocardiography. Am J Cardiol 1984; 54: 1283-5.</mixed-citation><mixed-citation xml:lang="en">Chandraratna PA, Nimalasuriya A, Kawanishi D, et al. Identification of the increased frequency of cardiovascular abnormalities associated with mitral valve prolapse by twodimensional echocardiography. Am J Cardiol 1984; 54: 1283-5.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">NishimuraRA,McGoonMD,ShubC,etal.Echocardiographically documented mitral-valve prolapse: long-term follow-up of 237 patients. N Engl J Med 1985; 313: 1305-9.</mixed-citation><mixed-citation xml:lang="en">NishimuraRA,McGoonMD,ShubC,etal.Echocardiographically documented mitral-valve prolapse: long-term follow-up of 237 patients. N Engl J Med 1985; 313: 1305-9.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Marks AR, Choong CY, Sanfilippo AJ, et al. Identification of high-risk and low-risk subgroups of patients with mitral-valve prolapse. N Engl J Med 1989; 320: 1031-6.</mixed-citation><mixed-citation xml:lang="en">Marks AR, Choong CY, Sanfilippo AJ, et al. Identification of high-risk and low-risk subgroups of patients with mitral-valve prolapse. N Engl J Med 1989; 320: 1031-6.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Takamoto T, Nitta M, Tsujibayashi T, et al. The prevalence and clinical features of pathologically abnormal mitral valve leaflets (myxomatous mitral valve) in the mitral valve prolapse syndrome: an echocardiographic and pathological comparative study. J Cardiol Suppl 1991; 25: 75-86.</mixed-citation><mixed-citation xml:lang="en">Takamoto T, Nitta M, Tsujibayashi T, et al. The prevalence and clinical features of pathologically abnormal mitral valve leaflets (myxomatous mitral valve) in the mitral valve prolapse syndrome: an echocardiographic and pathological comparative study. J Cardiol Suppl 1991; 25: 75-86.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Babuty D, Cosnay P, Breuillac JC, et al. Ventricular arrhythmia factors in mitral valve prolapse. Pacing Clin Electrophysiol 1994; 17: 1090-9.</mixed-citation><mixed-citation xml:lang="en">Babuty D, Cosnay P, Breuillac JC, et al. Ventricular arrhythmia factors in mitral valve prolapse. Pacing Clin Electrophysiol 1994; 17: 1090-9.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Zuppiroli A, Mori F, Favilli S, et al. Arrhythmias in mitral valve prolapse: relation to anterior mitral leaflet thickening, clinical variables, and color Doppler echocardiographic parameters. Am Heart J 1994; 128: 919-27.</mixed-citation><mixed-citation xml:lang="en">Zuppiroli A, Mori F, Favilli S, et al. Arrhythmias in mitral valve prolapse: relation to anterior mitral leaflet thickening, clinical variables, and color Doppler echocardiographic parameters. Am Heart J 1994; 128: 919-27.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Zuppiroli A, Rinaldi M, Kramer-Fox R, et al. Natural history of mitral valve prolapse. Am J Cardiol 1995; 75: 1028-32.</mixed-citation><mixed-citation xml:lang="en">Zuppiroli A, Rinaldi M, Kramer-Fox R, et al. Natural history of mitral valve prolapse. Am J Cardiol 1995; 75: 1028-32.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Rosen SE, Borer JS, Hochreiter C, et al. Natural history of the asymptomatic/minimally symptomatic patient with severe mitral regurgitation secondary to mitral valve prolapse and normal right and left ventricular performance. Am J Cardiol 1994; 74: 374-80.</mixed-citation><mixed-citation xml:lang="en">Rosen SE, Borer JS, Hochreiter C, et al. Natural history of the asymptomatic/minimally symptomatic patient with severe mitral regurgitation secondary to mitral valve prolapse and normal right and left ventricular performance. Am J Cardiol 1994; 74: 374-80.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Schaal SF. Ventricular arrhythmias in patients with mitral valve prolapse. Cardiovasc Clin 1992; 22: 307-16.</mixed-citation><mixed-citation xml:lang="en">Schaal SF. Ventricular arrhythmias in patients with mitral valve prolapse. Cardiovasc Clin 1992; 22: 307-16.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Pepi M, Tamborini G, Maltagliati A, et al. Head-to-head comparison of two- and three-dimensional transthoracic and transesophageal echocardiography in the localization of mitral valve prolapse. JACC 2006; 48(12): 2524-30.</mixed-citation><mixed-citation xml:lang="en">Pepi M, Tamborini G, Maltagliati A, et al. Head-to-head comparison of two- and three-dimensional transthoracic and transesophageal echocardiography in the localization of mitral valve prolapse. JACC 2006; 48(12): 2524-30.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Devereux RB. Mitral valve prolapse. J Am Med Womens Assoc 1994; 49(6): 192-7.</mixed-citation><mixed-citation xml:lang="en">Devereux RB. Mitral valve prolapse. J Am Med Womens Assoc 1994; 49(6): 192-7.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Сторожаков Г.И., Верещагина Г.С., Малышева Н.В. Стратификация риска и выбор клинической тактики у пациентов с пролапсом митрального клапана. Серд недостат 2001; 1(6).</mixed-citation><mixed-citation xml:lang="en">Сторожаков Г.И., Верещагина Г.С., Малышева Н.В. Стратификация риска и выбор клинической тактики у пациентов с пролапсом митрального клапана. Серд недостат 2001; 1(6).</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Avierinos JF, Gersh BJ, Melton LJ, 3rd et al. Natural history</mixed-citation><mixed-citation xml:lang="en">Avierinos JF, Gersh BJ, Melton LJ, 3rd et al. Natural history</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
